{"Name":"Amyloidosis","DiseaseID__c":"GARD:0018676","id":18676,"encodedName":"amyloidosis","IsDeleted":false,"Disease_Name_Full__c":"Amyloidosis","Xref_IDs__c":"17602002; C0002726; C2868; D000686; DOID:9120; E85; MEDGEN:272; MONDO:0019065; ORPHA:69","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":2,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":2,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0019065","Disease_Description__c":"A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.","GARD_Name__c":"Amyloidosis","GARD_Synonym__c":"amyloid; amyloid deposition; amyloid disease; amyloidoses; amyloidosis (disease)","Curated_Disease_Description_Source__c":"MONDO:0019065","Curated_Disease_Description__c":"Amyloidosis occurs when abnormal proteins called amyloids build up and form deposits. The deposits can collect in organs such as the kidney and heart. This can cause the organs to become stiff and unable to work the way they should.\r\n\r\nThere are three main types of amyloidosis: 1) Primary - with no known cause 2) Secondary - caused by another disease, including some types of cancer 3) Familial - passed down through genes.\r\n\r\nSymptoms can vary, depending upon which organs are affected. Treatment depends on the type of amyloidosis you have. The goal is to help with symptoms and limit the production of proteins. If another disease is the cause, it needs to be treated.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:69","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0019065","ORPHANET_ID__c":"ORPHA:69","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Amiloidosis","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"amiloidosis","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:98023","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Amyloidosis occurs when abnormal proteins called amyloids build up and form deposits. The deposits can collect in organs such as the kidney and heart. This can cause the organs to become stiff and unable to work the way they should.\r\n\r\nThere are three main types of amyloidosis: 1) Primary - with no known cause 2) Secondary - caused by another disease, including some types of cancer 3) Familial - passed down through genes.\r\n\r\nSymptoms can vary, depending upon which organs are affected. Treatment depends on the type of amyloidosis you have. The goal is to help with symptoms and limit the production of proteins. If another disease is the cause, it needs to be treated.","Curated_Disease_Description_Source__c":"MONDO:0019065","GARD_Synonym__c":"amyloid; amyloid deposition; amyloid disease; amyloidoses; amyloidosis (disease)","Name":"Amyloidosis","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Amyloidosis Foundation","Website__c":"https://www.amyloidosis.org/"},{"Account_Name__c":"Amyloidosis Research Consortium","Website__c":"https://www.arci.org/"},{"Account_Name__c":"Canadian Amyloidosis Support Network","Website__c":"https://amyloidosiscanada.org/"},{"Account_Name__c":"Amyloidosis Support Groups Inc.","Website__c":"https://www.amyloidosissupport.org/"},{"Account_Name__c":"Smart Patients","Website__c":"https://www.smartpatients.com/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Rheumatology","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:69"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.orpha.net/en/disease/detail/69","Source__c":"C0002726; MONDO:0019065; ORPHA:69","Xref__c":"ORPHA:69"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=272","Source__c":"C0002726","Xref__c":"MEDGEN:272"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2868","Source__c":"C0002726; MONDO:0019065","Xref__c":"C2868"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A9120","Source__c":"MONDO:0019065","Xref__c":"DOID:9120"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=17602002","Source__c":"C0002726; MONDO:0019065","Xref__c":"17602002"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C000686","Source__c":"C0002726; MONDO:0019065","Xref__c":"D000686"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0002726","Source__c":"C0002726","Xref__c":"C0002726"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0019065","Source__c":"GARD:0018676","Xref__c":"MONDO:0019065"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/E85","Source__c":"MONDO:0019065","Xref__c":"E85"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0011034","Source__c":"C0002726","Xref__c":"HP:0011034"},{"URL__c":"https://www.niddk.nih.gov/health-information/kidney-disease/amyloidosis"},{"URL__c":"https://medlineplus.gov/amyloidosis.html"}],"tags":{"Specialist":["Rheumatology","Pediatrics"]},"synonyms":["amyloid"," amyloid deposition"," amyloid disease"," amyloidoses"," amyloidosis (disease)"]}