{"Name":"Congenital herpes simplex virus infection","DiseaseID__c":"GARD:0018687","id":18687,"encodedName":"congenital-herpes-simplex-virus-infection","IsDeleted":false,"Disease_Name_Full__c":"Congenital herpes simplex virus infection","Xref_IDs__c":"91576008; C0276225; MEDGEN:82910; MONDO:0017381; ORPHA:293","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":2,"Description_Source__c":"MONDO:0017381","Disease_Description__c":"Congenital herpes virus infection is a group of anomalies that an infant may present as a result of maternal infection and subsequent foetal infection with herpes virus. This virus causes recurrent cutaneous infections in adults, often involving the lips or the genitalia. Herpes infections in other organs, such as the liver or central nervous system, are less frequent.","GARD_Name__c":"Congenital herpes simplex virus infection","GARD_Synonym__c":"antenatal herpes simplex virus infection; congenital herpes simplex; congenital herpes simplex infection; mother-to-child transmission of herpes simplex virus infection; neonatal herpes simplex; simplexvirus caused infectious embryofetopathy; simplexvirus infectious embryofetopathy","Curated_Disease_Description_Source__c":"ORPHA:293","Curated_Disease_Description__c":"Congenital herpes virus infection is a group of anomalies that an infant may present as a result of maternal infection and subsequent fetal infection with herpes virus. This virus causes recurrent cutaneous infections in adults, often involving the lips or the genitalia. Herpes infections in other organs, such as the liver or central nervous system, are less frequent.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"during Pregnancy and as a Newborn","SourceID__c":"ORPHA:293","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0017381","ORPHANET_ID__c":"ORPHA:293","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Infección congénita por el virus del herpes simple","Spanish_Description_Source__c":"ORPHA:293","Spanish_Description__c":"La infección congénita por el virus del herpes es un grupo de anomalías que un niño puede presentar como resultado de la infección materna y posterior infección fetal con el virus del herpes. Este virus causa infecciones cutáneas recurrentes en los adultos, a menudo en los labios o los genitales. Las infecciones por herpes en otros órganos, como el hígado o el sistema nervioso central, son menos frecuentes.","Spanish_Disease_Name__c":"infección congénita por el virus del herpes simple","Spanish_GARD_Synonym__c":"infección prenatal por el virus del herpes simple; transmisión materna de la infección por el virus del herpes simple","Category_Linearization__c":"ORPHA:93890","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Congenital herpes virus infection is a group of anomalies that an infant may present as a result of maternal infection and subsequent fetal infection with herpes virus. This virus causes recurrent cutaneous infections in adults, often involving the lips or the genitalia. Herpes infections in other organs, such as the liver or central nervous system, are less frequent.","Curated_Disease_Description_Source__c":"ORPHA:293","GARD_Synonym__c":"antenatal herpes simplex virus infection; congenital herpes simplex; congenital herpes simplex infection; mother-to-child transmission of herpes simplex virus infection; neonatal herpes simplex; simplexvirus caused infectious embryofetopathy; simplexvirus infectious embryofetopathy","Name":"Congenital herpes simplex virus infection","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Infectious Disease","Tag_Category__c":"Disease Category;Specialist","category_description":"Infectious diseases are caused by bacteria, viruses, fungi, or parasites entering the body, multiplying, and spreading illness.","curated_tag_name":"Infectious diseases"},{"Tag_Name__c":"Congenital Abnormality","Tag_Category__c":"Disease Category","category_description":"Birth defects are structural changes present at birth that can affect almost any part of the body, including how the body looks, works, or both.","curated_tag_name":"Birth defects"},{"Tag_Name__c":"Infectious Embryofetopathy","Tag_Category__c":"Cause","curated_tag_name":"Congenital Infectious Diseases"},{"Tag_Name__c":"Rare Viral Disease","Tag_Category__c":"Cause","curated_tag_name":"Viral Infectious Diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Neonatal","Provided_By__c":"ORPHA:293"},{"Age_At_Onset__c":"Antenatal","Provided_By__c":"ORPHA:293"}],"External_Identifier_Disease__c":[{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=91576008","Source__c":"C0276225; MONDO:0017381","Xref__c":"91576008"},{"URL__c":"https://www.orpha.net/en/disease/detail/293","Source__c":"C0276225; MONDO:0017381","Xref__c":"ORPHA:293"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0276225","Source__c":"C0276225","Xref__c":"C0276225"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=82910","Source__c":"C0276225","Xref__c":"MEDGEN:82910"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0017381","Source__c":"GARD:0018687","Xref__c":"MONDO:0017381"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:293","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001511","HPO_Synonym__c":"Fetal growth restriction; FGR; In utero growth retardation; Intrauterine growth failure; Intrauterine growth restriction; Intrauterine growth retardation, IUGR; Intrauterine retardation; IUGR; Prenatal growth deficiency; Prenatal growth failure; Prenatal growth retardation; Prenatal onset growth retardation; Prenatal-onset growth retardation; Small for gestational age infant","HPO_Name__c":"Intrauterine growth retardation","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:293","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Head circumference below 2 standard deviations below the mean for age and sex.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000252","HPO_Synonym__c":"Abnormally small cranium; Abnormally small skull; Decreased circumference of cranium; Decreased size of cranium; Decreased size of skull; Reduced head circumference; small cranium; Small head circumference","HPO_Name__c":"Microcephaly","Feature_System__c":"Nervous System; Musculoskeletal System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:293","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"The birth of a baby of less than 37 weeks of gestational age.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001622","HPO_Synonym__c":"Premature birth; Premature delivery; Premature delivery of affected infants; Preterm birth; Preterm delivery; Shortened gestation time","HPO_Name__c":"Premature birth","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:293","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A defect of development of the brain characterized by replacement of greater portions of the cerebral hemispheres and the corpus striatum by cerebrospinal fluid (CSF) and glial tissue.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002324","HPO_Synonym__c":"Hydrancephaly","HPO_Name__c":"Hydranencephaly","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Disease Category":["Infectious Disease","Congenital Abnormality"],"Specialist":["Infectious Disease","Pediatrics"],"Cause":["Infectious Embryofetopathy","Rare Viral Disease"]},"synonyms":["antenatal herpes simplex virus infection"," congenital herpes simplex"," congenital herpes simplex infection"," mother-to-child transmission of herpes simplex virus infection"," neonatal herpes simplex"," simplexvirus caused infectious embryofetopathy"," simplexvirus infectious embryofetopathy"]}