{"Name":"Histoplasmosis","DiseaseID__c":"GARD:0018692","id":18692,"encodedName":"histoplasmosis","IsDeleted":false,"Disease_Name_Full__c":"Histoplasmosis","Xref_IDs__c":"12962009; B39; C0019655; C77201; D006660; DOID:1731; HP:0032256; MEDGEN:42468; MONDO:0018312; ORPHA:390","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":1,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":2,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":2,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0018312","Disease_Description__c":"A disease caused by the fungus Histoplasma capsulatum. It primarily affects the lungs but can also occur as a disseminated disease that affects additional organs. The acute respiratory disease has symptoms similar to those of a cold or flu and it usually resolves without treatment in healthy individuals. The disseminated form is generally fatal if untreated.","GARD_Name__c":"Histoplasmosis","GARD_Synonym__c":"darling disease; histoplasma caused disease or disorder; histoplasma disease or disorder; histoplasma infectious disease","Curated_Disease_Description_Source__c":"ORPHA:390","Curated_Disease_Description__c":"A rare mycosis characterized by granulomatous inflammation primarily of the lung after inhalation of spores of <i>Histoplasma capsulatum</i>. The severity of clinical disease depends on the immune status of the individual and the size of the inoculum. In immunocompetent persons, the infection usually takes a self-limiting and asymptomatic or relatively mild, flu-like course. In immunocompromised patients, it can become progressive and disseminated, involving multiple organs and presenting with fever, pneumonia, hepatosplenomegaly, skin infiltrates, and endocarditis, among others.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":"ORPHA:390","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0018312","ORPHANET_ID__c":"ORPHA:390","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Histoplasmosis","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"histoplasmosis","Spanish_GARD_Synonym__c":"enfermedad de darling","Category_Linearization__c":"ORPHA:68416","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A rare mycosis characterized by granulomatous inflammation primarily of the lung after inhalation of spores of <i>Histoplasma capsulatum</i>. The severity of clinical disease depends on the immune status of the individual and the size of the inoculum. In immunocompetent persons, the infection usually takes a self-limiting and asymptomatic or relatively mild, flu-like course. In immunocompromised patients, it can become progressive and disseminated, involving multiple organs and presenting with fever, pneumonia, hepatosplenomegaly, skin infiltrates, and endocarditis, among others.","Curated_Disease_Description_Source__c":"ORPHA:390","GARD_Synonym__c":"darling disease; histoplasma caused disease or disorder; histoplasma disease or disorder; histoplasma infectious disease","Name":"Histoplasmosis","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"American Lung Association","Website__c":"https://www.lung.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Infectious Disease","Tag_Category__c":"Disease Category;Specialist","category_description":"Infectious diseases are caused by bacteria, viruses, fungi, or parasites entering the body, multiplying, and spreading illness.","curated_tag_name":"Infectious diseases"},{"Tag_Name__c":"Rare mycosis","Tag_Category__c":"Cause","curated_tag_name":"Fungal Infectious Diseases"}],"External_Identifier_Disease__c":[{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/B39","Source__c":"MONDO:0018312","Xref__c":"B39"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A1731","Source__c":"MONDO:0018312","Xref__c":"DOID:1731"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=12962009","Source__c":"C0019655; MONDO:0018312","Xref__c":"12962009"},{"URL__c":"https://www.orpha.net/en/disease/detail/390","Source__c":"C0019655; MONDO:0018312; ORPHA:390","Xref__c":"ORPHA:390"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0019655","Source__c":"C0019655","Xref__c":"C0019655"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=42468","Source__c":"C0019655","Xref__c":"MEDGEN:42468"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C006660","Source__c":"C0019655; MONDO:0018312","Xref__c":"D006660"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C77201","Source__c":"C0019655; MONDO:0018312","Xref__c":"C77201"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0018312","Source__c":"GARD:0018692","Xref__c":"MONDO:0018312"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0032256","Source__c":"C0019655","Xref__c":"HP:0032256"},{"URL__c":"https://www.cdc.gov/histoplasmosis/about/index.html"},{"URL__c":"https://medlineplus.gov/histoplasmosis.html"}],"tags":{"Disease Category":["Infectious Disease"],"Specialist":["Infectious Disease"],"Cause":["Rare mycosis"]},"synonyms":["darling disease"," histoplasma caused disease or disorder"," histoplasma disease or disorder"," histoplasma infectious disease"]}