{"Name":"Scleroderma","DiseaseID__c":"GARD:0018705","id":18705,"encodedName":"scleroderma","IsDeleted":false,"Disease_Name_Full__c":"Scleroderma","Xref_IDs__c":"267874003; C0011644; C26746; DOID:419; HP:0100324; MEDGEN:3770; MONDO:0019340; ORPHA:801","USA_Estimate__c":"200,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":2,"World_Estimate__c":"800,000 to 5,000,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":2,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0019340","Disease_Description__c":"Scleroderma is a rare autoimmune connective tissue disorder characterized by abnormal hardening of the skin and, sometimes, other organs. It is classified into two main forms: localized scleroderma and systemic sclerosis (SSc), the latter comprising three subsets; diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc) and limited SSc (lSSc).","GARD_Name__c":"Scleroderma","GARD_Synonym__c":"dermatosclerosis; progressive systemic scleroderma; pseudoscleroderma; scleroderma (disease)","Curated_Disease_Description_Source__c":"MONDO:0019340","Curated_Disease_Description__c":"Scleroderma means \"hard skin.\" It's the name of an autoimmune disease that causes inflammation and thickening in the skin and other areas of the body. This inflammation causes you to have areas of tight, hard skin. Scleroderma may affect just one area of your body, or it can affect many systems in your body.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"200,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:801","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0019340","ORPHANET_ID__c":"ORPHA:801","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Esclerodermia","Spanish_Description_Source__c":"ORPHA:801","Spanish_Description__c":"La esclerodermia es un trastorno autoinmune poco frecuente del tejido conectivo, caracterizado por un endurecimiento anormal de la piel y, en ocasiones, también de otros órganos. Se clasifica en dos formas principales: la esclerodermia localizada y la esclerosis sistémica (SSc), distinguiéndose en esta forma tres subtipos distintos: la esclerosis sistémica cutánea difusa (dcSSc), la esclerosis sistémica cutánea limitada (lcSSc) y la esclerosis sistémica limitada (lSSc) (consulte estos términos).","Spanish_Disease_Name__c":"esclerodermia","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:89826","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Scleroderma means \"hard skin.\" It's the name of an autoimmune disease that causes inflammation and thickening in the skin and other areas of the body. This inflammation causes you to have areas of tight, hard skin. Scleroderma may affect just one area of your body, or it can affect many systems in your body.","Curated_Disease_Description_Source__c":"MONDO:0019340","GARD_Synonym__c":"dermatosclerosis; progressive systemic scleroderma; pseudoscleroderma; scleroderma (disease)","Name":"Scleroderma","Curated_USA_Estimate__c":"200,000","estimateUsa":"200,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"National Scleroderma Foundation","Website__c":"https://www.scleroderma.org"},{"Account_Name__c":"Global Autoimmune Institute","Website__c":"https://www.autoimmuneinstitute.org/"},{"Account_Name__c":"Steffens Scleroderma Foundation","Website__c":"http://www.steffens-scleroderma.org/"},{"Account_Name__c":"Scleroderma Research Foundation","Website__c":"https://srfcure.org/"},{"Account_Name__c":"Autoimmune Association","Website__c":"https://autoimmune.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Dermatology","Tag_Category__c":"Account;Disease Category;Specialist","category_description":"Skin diseases, or integumentary system diseases, affect the skin, hair, nails, sweat glands, or oil glands.","curated_tag_name":"Skin diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:801"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A419","Source__c":"MONDO:0019340","Xref__c":"DOID:419"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C26746","Source__c":"C0011644; MONDO:0019340","Xref__c":"C26746"},{"URL__c":"https://www.orpha.net/en/disease/detail/801","Source__c":"C0011644; MONDO:0019340; ORPHA:801","Xref__c":"ORPHA:801"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=3770","Source__c":"C0011644","Xref__c":"MEDGEN:3770"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0011644","Source__c":"C0011644","Xref__c":"C0011644"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0100324","Source__c":"C0011644","Xref__c":"HP:0100324"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0019340","Source__c":"GARD:0018705","Xref__c":"MONDO:0019340"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=267874003","Source__c":"C0011644","Xref__c":"267874003"},{"URL__c":"https://www.niams.nih.gov/health-topics/scleroderma"},{"URL__c":"https://medlineplus.gov/scleroderma.html"}],"tags":{"Account":["Dermatology"],"Disease Category":["Dermatology"],"Specialist":["Dermatology","Pediatrics"]},"synonyms":["dermatosclerosis"," progressive systemic scleroderma"," pseudoscleroderma"," scleroderma (disease)"]}