{"Name":"Diphtheria","DiseaseID__c":"GARD:0001875","id":1875,"encodedName":"diphtheria","IsDeleted":false,"Disease_Name_Full__c":"Diphtheria","Xref_IDs__c":"397428000; A36; C0012546; C34541; D004165; DOID:11405; MEDGEN:4334; MONDO:0005504; ORPHA:1679","USA_Estimate__c":"1,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":2,"World_Estimate__c":"1 to 8,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":2,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0005504","Disease_Description__c":"A Gram-positive bacterial infection caused by Corynebacterium diphtheriae. It usually involves the oral cavity, pharynx, and nasal cavity. Patients develop pseudomembranes in the affected areas and manifest signs and symptoms of an upper respiratory infection. The diphtheria toxin may cause myocarditis, polyneuritis, and other systemic effects.","GARD_Name__c":"Diphtheria","GARD_Synonym__c":"corynebacterium infection","Curated_Disease_Description_Source__c":"MONDO:0005504","Curated_Disease_Description__c":"A Gram-positive bacterial infection caused by Corynebacterium diphtheriae. It usually involves the oral cavity, pharynx, and nasal cavity. Patients develop pseudomembranes in the affected areas and manifest signs and symptoms of an upper respiratory infection. The diphtheria toxin may cause myocarditis, polyneuritis, and other systemic effects.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"1,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:1679","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0005504","ORPHANET_ID__c":"ORPHA:1679","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Difteria","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"difteria","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:68416","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A Gram-positive bacterial infection caused by Corynebacterium diphtheriae. It usually involves the oral cavity, pharynx, and nasal cavity. Patients develop pseudomembranes in the affected areas and manifest signs and symptoms of an upper respiratory infection. The diphtheria toxin may cause myocarditis, polyneuritis, and other systemic effects.","Curated_Disease_Description_Source__c":"MONDO:0005504","GARD_Synonym__c":"corynebacterium infection","Name":"Diphtheria","Curated_USA_Estimate__c":"1,000","estimateUsa":"1,000"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Infectious Disease","Tag_Category__c":"Disease Category;Specialist","category_description":"Infectious diseases are caused by bacteria, viruses, fungi, or parasites entering the body, multiplying, and spreading illness.","curated_tag_name":"Infectious diseases"},{"Tag_Name__c":"Rare Bacterial Infectious Disease","Tag_Category__c":"Cause","curated_tag_name":"Bacterial Infectious Disease"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:1679"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C004165","Source__c":"MONDO:0005504","Xref__c":"D004165"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0012546","Source__c":"C0012546","Xref__c":"C0012546"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A11405","Source__c":"MONDO:0005504","Xref__c":"DOID:11405"},{"URL__c":"https://www.orpha.net/en/disease/detail/1679","Source__c":"C0012546; MONDO:0005504; ORPHA:1679","Xref__c":"ORPHA:1679"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=4334","Source__c":"C0012546","Xref__c":"MEDGEN:4334"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34541","Source__c":"C0012546; MONDO:0005504","Xref__c":"C34541"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=397428000","Source__c":"MONDO:0005504","Xref__c":"397428000"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/A36","Source__c":"MONDO:0005504","Xref__c":"A36"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0005504","Source__c":"GARD:0001875","Xref__c":"MONDO:0005504"},{"URL__c":"https://medlineplus.gov/diphtheria.html"},{"URL__c":"https://www.cdc.gov/diphtheria/"}],"tags":{"Disease Category":["Infectious Disease"],"Specialist":["Infectious Disease","Pediatrics"],"Cause":["Rare Bacterial Infectious Disease"]},"synonyms":["corynebacterium infection"]}