{"Name":"Interstitial cystitis","DiseaseID__c":"GARD:0018825","id":18825,"encodedName":"interstitial-cystitis","IsDeleted":false,"Disease_Name_Full__c":"Interstitial cystitis","Xref_IDs__c":"111409009; 197834003; C0282488; C27189; D018856; DOID:13949; DOID:1678; MEDGEN:129176; MONDO:0018301; N30.1; ORPHA:37202","USA_Estimate__c":"200,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":2,"World_Estimate__c":"800,000 to 5,000,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":2,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0018301","Disease_Description__c":"A rare non-infectious, chronic and most often progressive disease of the urinary bladder. It is characterized by varying combinations and extent of pain, urinary frequency (pollakisuria), nocturia and urgency. Interstitial cystitis (IC) has a broad intersection with Bladder Pain Syndrome (BPS) and Overactive Bladder (OAB).","GARD_Name__c":"Interstitial cystitis","GARD_Synonym__c":"bladder pain syndrome; chronic interstitial cystitis; ic/bps; ic/pbs; interstitial cystitis, chronic; interstitial cystitis/bladder pain syndrome; interstitial cystitis/painful bladder syndrome; painful bladder syndrome; ulcerative cystitis","Curated_Disease_Description_Source__c":"MONDO:0018301","Curated_Disease_Description__c":"Interstitial cystitis (IC) is a condition that causes discomfort or pain in the bladder and a need to urinate frequently and urgently. It is far more common in women than in men. The symptoms vary from person to person. Some people may have pain without urgency or frequency. Others have urgency and frequency without pain. Women's symptoms often get worse during their periods. They may also have pain with sexual intercourse.\r\n\r\nThe cause of IC isn't known. There is no one test to tell if you have it. Doctors often run tests to rule out other possible causes of symptoms. There is no cure for IC, but treatments can help most people feel better. They include distending, or inflating, the bladder, bathing the inside of the bladder with a drug solution, oral medicines, electrical nerve stimulation, physical therapy, lifestyle changes, bladder training, and in rare cases, surgery.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"200,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:37202","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0018301","ORPHANET_ID__c":"ORPHA:37202","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Cistitis intersticial","Spanish_Description_Source__c":"ORPHA:37202","Spanish_Description__c":"Es una enfermedad crónica no infecciosa poco frecuente de la vejiga, y a menudo progresiva. Se caracteriza por combinaciones variables de dolor, frecuencia urinaria (polaquiuria), urgencia urinaria y nicturia. La cistitis intersticial (CI) se solapa en gran medida con el síndrome de dolor vesical (SDV) y la vejiga hiperactiva (VH).","Spanish_Disease_Name__c":"cistitis intersticial","Spanish_GARD_Synonym__c":"sdv/ci; svd/ci; síndrome de dolor vesical; síndrome de dolor vesical/cistitis intersticial; síndrome de vejiga dolorosa; síndrome de vejiga dolorosa/cistitis intersticial","Category_Linearization__c":"ORPHA:101433","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Interstitial cystitis (IC) is a condition that causes discomfort or pain in the bladder and a need to urinate frequently and urgently. It is far more common in women than in men. The symptoms vary from person to person. Some people may have pain without urgency or frequency. Others have urgency and frequency without pain. Women's symptoms often get worse during their periods. They may also have pain with sexual intercourse.\r\n\r\nThe cause of IC isn't known. There is no one test to tell if you have it. Doctors often run tests to rule out other possible causes of symptoms. There is no cure for IC, but treatments can help most people feel better. They include distending, or inflating, the bladder, bathing the inside of the bladder with a drug solution, oral medicines, electrical nerve stimulation, physical therapy, lifestyle changes, bladder training, and in rare cases, surgery.","Curated_Disease_Description_Source__c":"MONDO:0018301","GARD_Synonym__c":"bladder pain syndrome; chronic interstitial cystitis; ic/bps; ic/pbs; interstitial cystitis, chronic; interstitial cystitis/bladder pain syndrome; interstitial cystitis/painful bladder syndrome; painful bladder syndrome; ulcerative cystitis","Name":"Interstitial cystitis","Curated_USA_Estimate__c":"200,000","estimateUsa":"200,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Autoimmune Registry","Website__c":"https://www.autoimmuneregistry.org/"},{"Account_Name__c":"Global Autoimmune Institute","Website__c":"https://www.autoimmuneinstitute.org/"},{"Account_Name__c":"National Kidney Foundation","Website__c":"https://www.kidney.org/"},{"Account_Name__c":"Interstitial Cystitis Association","Website__c":"https://www.ichelp.org/"},{"Account_Name__c":"Autoimmune Association","Website__c":"https://autoimmune.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Urogenital Disorders","Tag_Category__c":"Disease Category","category_description":"Urinary and reproductive diseases affect the kidneys, ureters, bladder, urethra, or the reproductive organs.","curated_tag_name":"Urinary and reproductive diseases"},{"Tag_Name__c":"Urologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:37202"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A13949","Source__c":"MONDO:0018301","Xref__c":"DOID:13949"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A1678","Source__c":"MONDO:0018301","Xref__c":"DOID:1678"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C27189","Source__c":"C0282488; MONDO:0018301","Xref__c":"C27189"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C018856","Source__c":"C0282488; MONDO:0018301","Xref__c":"D018856"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=197834003","Source__c":"MONDO:0018301","Xref__c":"197834003"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=129176","Source__c":"C0282488","Xref__c":"MEDGEN:129176"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=111409009","Source__c":"C0282488; MONDO:0018301","Xref__c":"111409009"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0282488","Source__c":"C0282488","Xref__c":"C0282488"},{"URL__c":"https://www.orpha.net/en/disease/detail/37202","Source__c":"C0282488; MONDO:0018301; ORPHA:37202","Xref__c":"ORPHA:37202"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/N30.1","Source__c":"MONDO:0018301","Xref__c":"N30.1"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0018301","Source__c":"GARD:0018825","Xref__c":"MONDO:0018301"},{"URL__c":"https://www.niddk.nih.gov/health-information/urologic-diseases/interstitial-cystitis-bladder-pain-syndrome"},{"URL__c":"https://medlineplus.gov/interstitialcystitis.html"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"An abnormality of the genital system.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000078","HPO_Synonym__c":"Genital abnormalities; Genital abnormality; Genital anomalies; Genital defects","HPO_Name__c":"Abnormality of the genital system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Abnormally increased production of urine during the night leading to an unusually frequent need to urinate.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000017","HPO_Synonym__c":"Nycturia","HPO_Name__c":"Nocturia","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover from these moods; having a pessimistic outlook on the future; feeling a pervasive sense of shame; having a low self-worth; experiencing thoughts of suicide and engaging in suicidal behavior.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000716","HPO_Synonym__c":"Depression; Depressive episode; Depressivity","HPO_Name__c":"Depression","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"An anomaly of the labia, the externally visible portions of the vulva.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000058","HPO_Synonym__c":"Abnormality of the labia","HPO_Name__c":"Abnormal labia morphology","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Dysfunction of the urinary bladder.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000009","HPO_Synonym__c":"Poor bladder function","HPO_Name__c":"Functional abnormality of the bladder","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Increased frequency of urination.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100515","HPO_Synonym__c":"Frequent urination","HPO_Name__c":"Pollakisuria","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"An abnormality of the ovulation cycle.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000140","HPO_Synonym__c":"Abnormality of the menstrual cycle","HPO_Name__c":"Abnormality of the menstrual cycle","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Painful or difficult urination.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100518","HPO_Synonym__c":"Painful or difficult urination","HPO_Name__c":"Dysuria","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"An abnormality of the urinary bladder.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000014","HPO_Name__c":"Abnormality of the bladder","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Inflammation of the urinary bladder.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100577","HPO_Synonym__c":"Cystitis of the urinary bladder; Urinary bladder inflammation","HPO_Name__c":"Urinary bladder inflammation","Feature_System__c":"Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An abnormal elevation of the C-reactive protein level in the blood circulation.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0011227","HPO_Synonym__c":"Elevated C-reactive protein level","HPO_Name__c":"Elevated circulating C-reactive protein concentration","HPO_Feature_Type__c":"Lab"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Any structural abnormality of the vagina.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000142","HPO_Synonym__c":"Vaginal malformation","HPO_Name__c":"Abnormal vagina morphology","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Urge incontinence is the strong, sudden need to urinate.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000012","HPO_Synonym__c":"Overactive bladder; Urgent micturition; Urinary urgency","HPO_Name__c":"Urinary urgency","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"An abnormality of the urethra, i.e., of the tube which connects the urinary bladder to the outside of the body.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000795","HPO_Synonym__c":"Urethra issue","HPO_Name__c":"Abnormality of the urethra","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Pain perceived in the area of the pelvis, the lower part of the abdomen located between the hip bones.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0034267","HPO_Synonym__c":"Pain in the pelvis","HPO_Name__c":"Pelvic pain","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Pain in and around the anus or rectum (perianal region).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0500005","HPO_Synonym__c":"Anal pain; Anorectal pain; Proctalgia; Rectal pain","HPO_Name__c":"Anal pain","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"The occurrence of an immune reaction against the organism's own cells or tissues.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002960","HPO_Synonym__c":"Autoimmune condition; Autoimmune disease; Autoimmune disorder; Autoimmunity","HPO_Name__c":"Autoimmunity","Feature_System__c":"Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An abnormality in the production or cellular release of tumor necrosis factor.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0011118","HPO_Synonym__c":"Abnormality of cachectin secretion; Abnormality of cachexin secretion","HPO_Name__c":"Abnormality of tumor necrosis factor secretion","Feature_System__c":"Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:37202","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Recurrent or persistent genital pain associated with sexual intercourse.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0030016","HPO_Name__c":"Dyspareunia","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Disease Category":["Urogenital Disorders"],"Specialist":["Urologist","Pediatrics"]},"synonyms":["bladder pain syndrome"," chronic interstitial cystitis"," ic/bps"," ic/pbs"," interstitial cystitis, chronic"," interstitial cystitis/bladder pain syndrome"," interstitial cystitis/painful bladder syndrome"," painful bladder syndrome"," ulcerative cystitis"]}