{"Name":"Pneumococcal meningitis","DiseaseID__c":"GARD:0018849","id":18849,"encodedName":"pneumococcal-meningitis","IsDeleted":false,"Disease_Name_Full__c":"Pneumococcal meningitis","Xref_IDs__c":"51169003; C0025295; C157958; D008586; G00.1; MEDGEN:44354; MONDO:0006913; ORPHA:55655","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0006913","Disease_Description__c":"An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with otitis media; mastoiditis; sinusitis; respiratory tract infections; sickle cell disease (anemia, sickle cell); skull fractures; and other disorders. Clinical manifestations include fever; headache; neck stiffness; and somnolence followed by seizures; focal neurologic deficits (notably deafness); and coma. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)","GARD_Name__c":"Pneumococcal meningitis","GARD_Synonym__c":"streptococcus pneumoniae caused infectious meningitis; streptococcus pneumoniae infectious meningitis","Curated_Disease_Description_Source__c":"ORPHA:55655","Curated_Disease_Description__c":"A rare infectious disease of the nervous system caused by the bacterium <i>Streptococcus pneumoniae</i>, which is commonly part of the bacterial flora colonizing the nasopharyngeal mucosa. The disease is clinically characterized by typical symptoms of acute leptomeningitis, like fever, headache, neck stiffness, vomiting, and clouding of consciousness. It is frequently fatal and, in surviving patients, often accompanied by long-term sequelae, especially focal neurological deficits, hearing loss, cognitive impairment, and epilepsy.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":"ORPHA:55655","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0006913","ORPHANET_ID__c":"ORPHA:55655","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Meningitis neumocócica","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"meningitis neumocócica","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:68416","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A rare infectious disease of the nervous system caused by the bacterium <i>Streptococcus pneumoniae</i>, which is commonly part of the bacterial flora colonizing the nasopharyngeal mucosa. The disease is clinically characterized by typical symptoms of acute leptomeningitis, like fever, headache, neck stiffness, vomiting, and clouding of consciousness. It is frequently fatal and, in surviving patients, often accompanied by long-term sequelae, especially focal neurological deficits, hearing loss, cognitive impairment, and epilepsy.","Curated_Disease_Description_Source__c":"ORPHA:55655","GARD_Synonym__c":"streptococcus pneumoniae caused infectious meningitis; streptococcus pneumoniae infectious meningitis","Name":"Pneumococcal meningitis","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Meningitis Research Foundation","Website__c":"https://www.meningitis.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Infectious Disease","Tag_Category__c":"Disease Category;Specialist","category_description":"Infectious diseases are caused by bacteria, viruses, fungi, or parasites entering the body, multiplying, and spreading illness.","curated_tag_name":"Infectious diseases"},{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"},{"Tag_Name__c":"Rare Bacterial Infectious Disease","Tag_Category__c":"Cause","curated_tag_name":"Bacterial Infectious Disease"},{"Tag_Name__c":"Epilepsy","Tag_Category__c":"Account;Specialist","curated_tag_name":"Epilepsy"}],"External_Identifier_Disease__c":[{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/G00.1","Source__c":"MONDO:0006913","Xref__c":"G00.1"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=44354","Source__c":"C0025295","Xref__c":"MEDGEN:44354"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=51169003","Source__c":"C0025295; MONDO:0006913","Xref__c":"51169003"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0025295","Source__c":"C0025295","Xref__c":"C0025295"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C157958","Source__c":"C0025295; MONDO:0006913","Xref__c":"C157958"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C008586","Source__c":"C0025295; MONDO:0006913","Xref__c":"D008586"},{"URL__c":"https://www.orpha.net/en/disease/detail/55655","Source__c":"C0025295; MONDO:0006913; ORPHA:55655","Xref__c":"ORPHA:55655"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0006913","Source__c":"GARD:0018849","Xref__c":"MONDO:0006913"}],"tags":{"Disease Category":["Infectious Disease","Neurology"],"Specialist":["Infectious Disease","Neurology","Epilepsy"],"Cause":["Rare Bacterial Infectious Disease"],"Account":["Epilepsy"]},"synonyms":["streptococcus pneumoniae caused infectious meningitis"," streptococcus pneumoniae infectious meningitis"]}