{"Name":"Pili gemini","DiseaseID__c":"GARD:0019026","id":19026,"encodedName":"pili-gemini","IsDeleted":false,"Disease_Name_Full__c":"Pili gemini","Xref_IDs__c":"42829009; C0019571; C537188; MEDGEN:42460; MONDO:0019330; ORPHA:79492","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":6,"No_of_Age_at_Onset__c":4,"Description_Source__c":"MONDO:0019330","Disease_Description__c":"Pili gemini defines a situation where the papilla's tip of a hair follicle splits during the anagen phase and consequently grows two hair shafts emerging through a single pilary canal. A papilla tip that divides in several tips will produce several hair shafts, a situation named pili multigemini. Pili gemini or multigemini can occur in each type of hair.","GARD_Name__c":"Pili gemini","GARD_Synonym__c":"pili multigemini","Curated_Disease_Description_Source__c":"MONDO:0019330","Curated_Disease_Description__c":"Pili gemini defines a situation where the papilla's tip of a hair follicle splits during the anagen phase and consequently grows two hair shafts emerging through a single pilary canal. A papilla tip that divides in several tips will produce several hair shafts, a situation named pili multigemini. Pili gemini or multigemini can occur in each type of hair.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"at a variety of ages","SourceID__c":"ORPHA:79492","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0019330","ORPHANET_ID__c":"ORPHA:79492","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Pili gemini","Spanish_Description_Source__c":"ORPHA:79492","Spanish_Description__c":"Pili gemini define una situación en la que la punta de la papila del folículo piloso se divide en la fase anágena, dando lugar al crecimiento de dos tallos pilosos que emergen a través de un único canal piloso. Si la punta de una papila se divide en varios tallos producirá varios cabellos, una situación denominada pili multigemini. Tanto pili gemini como multigemini pueden producirse en todo tipo de cabello.","Spanish_Disease_Name__c":"pili gemini","Spanish_GARD_Synonym__c":"pili multigemini","Category_Linearization__c":"ORPHA:89826","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Pili gemini defines a situation where the papilla's tip of a hair follicle splits during the anagen phase and consequently grows two hair shafts emerging through a single pilary canal. A papilla tip that divides in several tips will produce several hair shafts, a situation named pili multigemini. Pili gemini or multigemini can occur in each type of hair.","Curated_Disease_Description_Source__c":"MONDO:0019330","GARD_Synonym__c":"pili multigemini","Name":"Pili gemini","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Genetics","Tag_Category__c":"Cause;Disease Category;Specialist","category_description":"Genetic diseases affect the DNA, or genetic instructions, which directs how tissues, organs, and body systems function.","curated_tag_name":"Genetic diseases"},{"Tag_Name__c":"Dermatology","Tag_Category__c":"Account;Disease Category;Specialist","category_description":"Skin diseases, or integumentary system diseases, affect the skin, hair, nails, sweat glands, or oil glands.","curated_tag_name":"Skin diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Elderly","Provided_By__c":"ORPHA:79492"},{"Age_At_Onset__c":"Childhood","Provided_By__c":"ORPHA:79492"},{"Age_At_Onset__c":"Adolescent","Provided_By__c":"ORPHA:79492"},{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:79492"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=42460","Source__c":"C0019571","Xref__c":"MEDGEN:42460"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0019571","Source__c":"C0019571","Xref__c":"C0019571"},{"URL__c":"https://www.orpha.net/en/disease/detail/79492","Source__c":"C0019571; MONDO:0019330; ORPHA:79492","Xref__c":"ORPHA:79492"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C537188","Source__c":"MONDO:0019330","Xref__c":"C537188"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=42829009","Source__c":"C0019571; MONDO:0019330","Xref__c":"42829009"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0019330","Source__c":"GARD:0019026","Xref__c":"MONDO:0019330"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:79492","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An abnormal structure of the hairshaft, i.e., of the nongrowing portion of a hair that protrudes from the skin.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0003328","HPO_Name__c":"Abnormal hairshaft morphology","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:79492","HPO_Frequency__c":"Always (100%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0003329","HPO_Name__c":"Hair shafts flattened at irregular intervals and twisted through 180 degrees about their axes","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Cause":["Genetics"],"Disease Category":["Genetics","Dermatology"],"Specialist":["Genetics","Dermatology","Pediatrics"],"Account":["Dermatology"]},"synonyms":["pili multigemini"]}