{"Name":"Epidemic louse-borne typhus","DiseaseID__c":"GARD:0019032","id":19032,"encodedName":"epidemic-louse-borne-typhus","IsDeleted":false,"Disease_Name_Full__c":"Epidemic louse-borne typhus","Xref_IDs__c":"C0041473; C84689; DOID:0050480; MEDGEN:21744; MONDO:0019362; ORPHA:83314","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0019362","Disease_Description__c":"A gram-negative bacterial infection caused by Rickettsia prowazekii. It is spread by lice infected with the bacteria. Signs and symptoms include sudden headache, generalized muscle pain, malaise, and macular skin lesions. The infection may affect the central nervous system causing encephalitis.","GARD_Name__c":"Epidemic louse-borne typhus","GARD_Synonym__c":"classical typhus; epidemic typhus; epidemic typhus fever; european typhus; exanthematic typhus; fleckfieber; louse-borne epidemic typhus; louse-borne typhus; louse-borne typhus fever; sylvatic typhus; tabardillo; tifus exanthematico; typhus due to rickettsia prowazekii","Curated_Disease_Description_Source__c":"ORPHA:83314","Curated_Disease_Description__c":"A Rickettsial disease characterized by malaise and vague symptoms before the onset of high fever, headache, severe myalgias and less commonly petechial rash on the trunk and limbs, nausea, vomiting, coughing and pneumonia. Patients may also have some central nervous system disturbances, such as meningeal irritation, confusion, drowsiness, seizures, coma, and hearing loss.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:83314","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0019362","ORPHANET_ID__c":"ORPHA:83314","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Tifus epidémico","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"tifus epidémico","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:68416","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A Rickettsial disease characterized by malaise and vague symptoms before the onset of high fever, headache, severe myalgias and less commonly petechial rash on the trunk and limbs, nausea, vomiting, coughing and pneumonia. Patients may also have some central nervous system disturbances, such as meningeal irritation, confusion, drowsiness, seizures, coma, and hearing loss.","Curated_Disease_Description_Source__c":"ORPHA:83314","GARD_Synonym__c":"classical typhus; epidemic typhus; epidemic typhus fever; european typhus; exanthematic typhus; fleckfieber; louse-borne epidemic typhus; louse-borne typhus; louse-borne typhus fever; sylvatic typhus; tabardillo; tifus exanthematico; typhus due to rickettsia prowazekii","Name":"Epidemic louse-borne typhus","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Infectious Disease","Tag_Category__c":"Disease Category;Specialist","category_description":"Infectious diseases are caused by bacteria, viruses, fungi, or parasites entering the body, multiplying, and spreading illness.","curated_tag_name":"Infectious diseases"},{"Tag_Name__c":"Rare Bacterial Infectious Disease","Tag_Category__c":"Cause","curated_tag_name":"Bacterial Infectious Disease"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:83314"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0041473","Source__c":"C0041473","Xref__c":"C0041473"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=21744","Source__c":"C0041473","Xref__c":"MEDGEN:21744"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0050480","Source__c":"MONDO:0019362","Xref__c":"DOID:0050480"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C84689","Source__c":"C0041473; MONDO:0019362","Xref__c":"C84689"},{"URL__c":"https://www.orpha.net/en/disease/detail/83314","Source__c":"C0041473; MONDO:0019362; ORPHA:83314","Xref__c":"ORPHA:83314"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C014438","Source__c":"C0041473","Xref__c":"D014438"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0019362","Source__c":"GARD:0019032","Xref__c":"MONDO:0019362"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=39111003","Source__c":"C0041473","Xref__c":"39111003"}],"tags":{"Disease Category":["Infectious Disease"],"Specialist":["Infectious Disease","Pediatrics"],"Cause":["Rare Bacterial Infectious Disease"]},"synonyms":["classical typhus"," epidemic typhus"," epidemic typhus fever"," european typhus"," exanthematic typhus"," fleckfieber"," louse-borne epidemic typhus"," louse-borne typhus"," louse-borne typhus fever"," sylvatic typhus"," tabardillo"," tifus exanthematico"," typhus due to rickettsia prowazekii"]}