{"Name":"Endemic typhus","DiseaseID__c":"GARD:0019033","id":19033,"encodedName":"endemic-typhus","IsDeleted":false,"Disease_Name_Full__c":"Endemic typhus","Xref_IDs__c":"C0041472; C84688; D014437; DOID:0050481; MEDGEN:11977; MONDO:0000330; ORPHA:83315","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0000330","Disease_Description__c":"A bacterial infection caused by Rickettsia typhi.","GARD_Name__c":"Endemic typhus","GARD_Synonym__c":"cat flea rickettsiosis; endemic flea-borne typhus; endemic typhus fever; flea-born typhus; flea-borne typhus; fleaborne typhus; murine endemic flea typhus; murine typhus; rat-flea typhus; rickettsia felis spotted fever; shop typhus; toulon typhus; typhus due to rickettsia typhi; urban typhus; urban typhus of malaya","Curated_Disease_Description_Source__c":"ORPHA:83315","Curated_Disease_Description__c":"A Rickettsial disease characterized by headache, fever and macular or maculopapular rash, with only a portion of patients manifesting all three symptoms. Other common symptoms are chills, malaise, stomach pain, myalgia, loss of appetite, and in some cases confusion and altered level of consciousness. Classical laboratory abnormalities include elevated liver enzymes, lactate dehydrogenase, erythrocyte sedimentation rate and hypoalbuminemia. In children, typical symptoms occur in only half of patients, and abdominal pain, diarrhea, sore throat and anemia are more common.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:83315","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0000330","ORPHANET_ID__c":"ORPHA:83315","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Tifus murino","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"tifus murino","Spanish_GARD_Synonym__c":"tifus endémico; tifus transmitido por pulgas","Category_Linearization__c":"ORPHA:68416","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A Rickettsial disease characterized by headache, fever and macular or maculopapular rash, with only a portion of patients manifesting all three symptoms. Other common symptoms are chills, malaise, stomach pain, myalgia, loss of appetite, and in some cases confusion and altered level of consciousness. Classical laboratory abnormalities include elevated liver enzymes, lactate dehydrogenase, erythrocyte sedimentation rate and hypoalbuminemia. In children, typical symptoms occur in only half of patients, and abdominal pain, diarrhea, sore throat and anemia are more common.","Curated_Disease_Description_Source__c":"ORPHA:83315","GARD_Synonym__c":"cat flea rickettsiosis; endemic flea-borne typhus; endemic typhus fever; flea-born typhus; flea-borne typhus; fleaborne typhus; murine endemic flea typhus; murine typhus; rat-flea typhus; rickettsia felis spotted fever; shop typhus; toulon typhus; typhus due to rickettsia typhi; urban typhus; urban typhus of malaya","Name":"Endemic typhus","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Infectious Disease","Tag_Category__c":"Disease Category;Specialist","category_description":"Infectious diseases are caused by bacteria, viruses, fungi, or parasites entering the body, multiplying, and spreading illness.","curated_tag_name":"Infectious diseases"},{"Tag_Name__c":"Rare Bacterial Infectious Disease","Tag_Category__c":"Cause","curated_tag_name":"Bacterial Infectious Disease"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:83315"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=11977","Source__c":"C0041472","Xref__c":"MEDGEN:11977"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0041472","Source__c":"C0041472","Xref__c":"C0041472"},{"URL__c":"https://www.orpha.net/en/disease/detail/83315","Source__c":"C0041472; MONDO:0000330; ORPHA:83315","Xref__c":"ORPHA:83315"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0050481","Source__c":"MONDO:0000330","Xref__c":"DOID:0050481"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C84688","Source__c":"C0041472; MONDO:0000330","Xref__c":"C84688"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C014437","Source__c":"C0041472; MONDO:0000330","Xref__c":"D014437"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0000330","Source__c":"GARD:0019033","Xref__c":"MONDO:0000330"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=25668000","Source__c":"C0041472","Xref__c":"25668000"}],"tags":{"Disease Category":["Infectious Disease"],"Specialist":["Infectious Disease","Pediatrics"],"Cause":["Rare Bacterial Infectious Disease"]},"synonyms":["cat flea rickettsiosis"," endemic flea-borne typhus"," endemic typhus fever"," flea-born typhus"," flea-borne typhus"," fleaborne typhus"," murine endemic flea typhus"," murine typhus"," rat-flea typhus"," rickettsia felis spotted fever"," shop typhus"," toulon typhus"," typhus due to rickettsia typhi"," urban typhus"," urban typhus of malaya"]}