{"Name":"Inhalational anthrax","DiseaseID__c":"GARD:0020657","id":20657,"encodedName":"inhalational-anthrax","IsDeleted":false,"Disease_Name_Full__c":"Inhalational anthrax","Xref_IDs__c":"11389007; A22.1; C0155866; C571912; DOID:0050160; MEDGEN:57841; MONDO:0016595; ORPHA:247257","USA_Estimate__c":"1,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"1 to 8,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0016595","Disease_Description__c":"Inhalational anthrax is a rare acute systemic infection caused by the inhalation of <i>Bacillus anthracis</i> spores (e.g. through infected animal products, bioterrorism) and characterized by an initial stage where patients present with non specific symptoms (fever, cough, chills, fatigue) that is followed by an acute phase during which hemorrhagic mediastinitis occurs that can progress into meningitis, gastrointestinal involvement, and refractory shock, that can be fatal, if left untreated.","GARD_Name__c":"Inhalational anthrax","GARD_Synonym__c":"anthrax pneumonia; inhalation anthrax disease; pneumonia with anthrax; pulmonary anthrax; respiratory anthrax; respiratory anthrax disease; wool-sorters' disease; woolsorters' disease","Curated_Disease_Description_Source__c":"ORPHA:247257","Curated_Disease_Description__c":"Inhalational anthrax is a rare acute systemic infection caused by the inhalation of <i>Bacillus anthracis</i> spores (e.g., through infected animal products, bioterrorism) and characterized by an initial stage where patients present with non-specific symptoms (fever, cough, chills, fatigue) that is followed by an acute phase during which hemorrhagic mediastinitis occurs that can progress into meningitis, gastrointestinal involvement, and refractory shock, that can be fatal, if left untreated.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"1,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:247257","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0016595","ORPHANET_ID__c":"ORPHA:247257","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Enfermedad por inhalación de ántrax","Spanish_Description_Source__c":"ORPHA:247257","Spanish_Description__c":"Es una infección sistémica aguda poco frecuente causada por la inhalación de esporas de <i>Bacillus anthracis</i> (por ejemplo, a través de productos animales infectados, bioterrorismo) y caracterizada por una etapa inicial en la que los pacientes presentan síntomas inespecíficos (fiebre, tos, escalofríos, cansancio) seguida de una fase aguda durante la cual ocurre una mediastinitis hemorrágica que puede progresar a meningitis, compromiso gastrointestinal y shock refractario, que puede resultar fatal si no se trata.","Spanish_Disease_Name__c":"enfermedad por inhalación de ántrax","Spanish_GARD_Synonym__c":"enfermedad respiratoria por inhalación de ántrax","Category_Linearization__c":"ORPHA:68416","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Inhalational anthrax is a rare acute systemic infection caused by the inhalation of <i>Bacillus anthracis</i> spores (e.g., through infected animal products, bioterrorism) and characterized by an initial stage where patients present with non-specific symptoms (fever, cough, chills, fatigue) that is followed by an acute phase during which hemorrhagic mediastinitis occurs that can progress into meningitis, gastrointestinal involvement, and refractory shock, that can be fatal, if left untreated.","Curated_Disease_Description_Source__c":"ORPHA:247257","GARD_Synonym__c":"anthrax pneumonia; inhalation anthrax disease; pneumonia with anthrax; pulmonary anthrax; respiratory anthrax; respiratory anthrax disease; wool-sorters' disease; woolsorters' disease","Name":"Inhalational anthrax","Curated_USA_Estimate__c":"1,000","estimateUsa":"1,000"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Infectious Disease","Tag_Category__c":"Disease Category;Specialist","category_description":"Infectious diseases are caused by bacteria, viruses, fungi, or parasites entering the body, multiplying, and spreading illness.","curated_tag_name":"Infectious diseases"},{"Tag_Name__c":"Rare Bacterial Infectious Disease","Tag_Category__c":"Cause","curated_tag_name":"Bacterial Infectious Disease"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:247257"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C571912","Source__c":"MONDO:0016595","Xref__c":"C571912"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0155866","Source__c":"C0155866","Xref__c":"C0155866"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0050160","Source__c":"MONDO:0016595","Xref__c":"DOID:0050160"},{"URL__c":"https://www.orpha.net/en/disease/detail/247257","Source__c":"C0155866; MONDO:0016595; ORPHA:247257","Xref__c":"ORPHA:247257"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=57841","Source__c":"C0155866","Xref__c":"MEDGEN:57841"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=11389007","Source__c":"C0155866; MONDO:0016595","Xref__c":"11389007"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/A22.1","Source__c":"MONDO:0016595","Xref__c":"A22.1"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0016595","Source__c":"GARD:0020657","Xref__c":"MONDO:0016595"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=195902009","Source__c":"C0155866","Xref__c":"195902009"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:247257","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Any structural abnormality of the sweat gland.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000971","HPO_Synonym__c":"Abnormality of the sweat gland","HPO_Name__c":"Abnormal sweat gland morphology","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:247257","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002546","HPO_Synonym__c":"Incomprehensible speech","HPO_Name__c":"Incomprehensible speech","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:247257","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"The presence of hemorrhage within the body.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0011029","HPO_Synonym__c":"Internal bleeding","HPO_Name__c":"Internal hemorrhage","Feature_System__c":"Cardiovascular System; Blood and Blood-Forming Tissue","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:247257","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Respiratory distress is objectively observable as the physical or emotional consequences from the experience of dyspnea. The physical presentation of respiratory distress is generally referred to as labored breathing, while the sensation of respiratory distress is called shortness of breath or dyspnea.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002098","HPO_Synonym__c":"Breathing difficulties; Labored breathing; Respiratory difficulties","HPO_Name__c":"Respiratory distress","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:247257","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100806","HPO_Synonym__c":"Infection in blood stream","HPO_Name__c":"Sepsis","Feature_System__c":"Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:247257","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Difficult or labored breathing. Dyspnea is a subjective feeling only the patient can rate, e.g., on a Borg scale.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002094","HPO_Synonym__c":"Abnormal breathing; Breathing difficulty; Difficult to breathe; Difficulty breathing; Shortness of breath; Trouble breathing","HPO_Name__c":"Dyspnea","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:247257","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"A subjective feeling of tiredness characterized by a lack of energy and motivation.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012378","HPO_Synonym__c":"Fatigue; Tired; Tiredness","HPO_Name__c":"Fatigue","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:247257","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Body temperature elevated above the normal range.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001945","HPO_Synonym__c":"Fever; Hyperthermia; Pyrexia","HPO_Name__c":"Fever","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:247257","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"A type of focal autonomic seizure characterized by symptoms or signs pertaining to the gastrointestinal system as the initial semiological feature.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0011159","HPO_Synonym__c":"Abdominal aura; Epigastric aura; Epigastric auras; Localised seizure with epigastric sensation; Localized seizure with epigastric sensation; Partial seizure with epigastric sensation; Visceral aura","HPO_Name__c":"Focal autonomic seizure with epigastric sensation/nausea/vomiting/other gastrointestinal phenomena","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:247257","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002013","HPO_Synonym__c":"Emesis; Throwing up; Vomiting","HPO_Name__c":"Vomiting","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:247257","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Low Blood Pressure, vascular hypotension.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002615","HPO_Synonym__c":"Arterial hypotension; Low blood pressure","HPO_Name__c":"Hypotension","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:247257","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Lack of clarity and coherence of thought, perception, understanding, or action.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001289","HPO_Synonym__c":"Confusion; Disorientation; Easily confused; Mental disorientation","HPO_Name__c":"Confusion","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Disease Category":["Infectious Disease"],"Specialist":["Infectious Disease","Pediatrics"],"Cause":["Rare Bacterial Infectious Disease"]},"synonyms":["anthrax pneumonia"," inhalation anthrax disease"," pneumonia with anthrax"," pulmonary anthrax"," respiratory anthrax"," respiratory anthrax disease"," wool-sorters' disease"," woolsorters' disease"]}