{"Name":"Angiosarcoma","DiseaseID__c":"GARD:0020900","id":20900,"encodedName":"angiosarcoma","IsDeleted":false,"Disease_Name_Full__c":"Angiosarcoma","Xref_IDs__c":"403977003; 423022106; 863926008; C0018923; C3088; D006394; DOID:0001816; HP:0200058; MEDGEN:42385; MONDO:0016982; ORPHA:263413","USA_Estimate__c":"1,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":1,"World_Estimate__c":"1 to 8,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":1,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0016982","Disease_Description__c":"A malignant tumor arising from the endothelial cells of the blood vessels. Microscopically, it is characterized by frequently open vascular anastomosing and branching channels. The malignant cells that line the vascular channels are spindle or epithelioid and often display hyperchromatic nuclei. Angiosarcomas most frequently occur in the skin and breast. Patients with long-standing lymphedema are at increased risk of developing angiosarcoma.","GARD_Name__c":"Angiosarcoma","GARD_Synonym__c":"angiosarcoma (disease); blood vessel sarcoma; hemangioendothelial sarcoma; hemangioendothelioma, malignant; hemangiosarcoma; hemangiosarcoma, malignant; malignant angioendothelioma; malignant hemangioendothelioma; sarcoma of blood vessel; vascular sarcoma","Curated_Disease_Description_Source__c":"MONDO:0016982","Curated_Disease_Description__c":"Angiosarcoma is a rare and aggressive soft tissue sarcoma that begins in the cells that line blood vessels or lymph vessels and can occur in any area of the body. Angiosarcoma most commonly present in the skin and breast, but may also occur in the liver, spleen and other deep tissues, and are frequently metastatic at the time of diagnosis. Lymphedema is a common, preceding association of angiosarcoma (for example, following breast cancer treatment). Other rare associations include prior radiation exposure or treatment, and carcinogen exposure such as vinyl chloride, arsenic, and thorium dioxide.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"1,000","Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:263413","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0016982","ORPHANET_ID__c":"ORPHA:263413","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Angiosarcoma","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"angiosarcoma","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Angiosarcoma is a rare and aggressive soft tissue sarcoma that begins in the cells that line blood vessels or lymph vessels and can occur in any area of the body. Angiosarcoma most commonly present in the skin and breast, but may also occur in the liver, spleen and other deep tissues, and are frequently metastatic at the time of diagnosis. Lymphedema is a common, preceding association of angiosarcoma (for example, following breast cancer treatment). Other rare associations include prior radiation exposure or treatment, and carcinogen exposure such as vinyl chloride, arsenic, and thorium dioxide.","Curated_Disease_Description_Source__c":"MONDO:0016982","GARD_Synonym__c":"angiosarcoma (disease); blood vessel sarcoma; hemangioendothelial sarcoma; hemangioendothelioma, malignant; hemangiosarcoma; hemangiosarcoma, malignant; malignant angioendothelioma; malignant hemangioendothelioma; sarcoma of blood vessel; vascular sarcoma","Name":"Angiosarcoma","Curated_USA_Estimate__c":"1,000","estimateUsa":"1,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Sarcoma Foundation of America","Website__c":"https://www.curesarcoma.org/"},{"Account_Name__c":"National Organization of Vascular Anomalies","Website__c":"https://www.novanews.org/"},{"Account_Name__c":"American Cancer Society","Website__c":"https://www.cancer.org"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Congenital Abnormality","Tag_Category__c":"Disease Category","category_description":"Birth defects are structural changes present at birth that can affect almost any part of the body, including how the body looks, works, or both.","curated_tag_name":"Birth defects"},{"Tag_Name__c":"Vascular Medicine","Tag_Category__c":"Specialist","curated_tag_name":"Vascular diseases"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:263413"}],"External_Identifier_Disease__c":[{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=403977003","Source__c":"C0018923; MONDO:0016982","Xref__c":"403977003"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3088","Source__c":"C0018923; MONDO:0016982","Xref__c":"C3088"},{"URL__c":"https://www.orpha.net/en/disease/detail/263413","Source__c":"C0018923; MONDO:0016982; ORPHA:263413","Xref__c":"ORPHA:263413"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C006394","Source__c":"C0018923; MONDO:0016982","Xref__c":"D006394"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=42385","Source__c":"C0018923","Xref__c":"MEDGEN:42385"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0018923","Source__c":"C0018923","Xref__c":"C0018923"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0001816","Source__c":"MONDO:0016982","Xref__c":"DOID:0001816"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0200058","Source__c":"C0018923","Xref__c":"HP:0200058"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=33176006","Source__c":"C0018923","Xref__c":"33176006"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=39000009","Source__c":"C0018923","Xref__c":"39000009"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=863926008","Source__c":"C0018923","Xref__c":"863926008"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0016982","Source__c":"GARD:0020900","Xref__c":"MONDO:0016982"},{"URL__c":"https://secure.ssa.gov/apps10/poms.nsf/lnx/0423022106","Xref__c":"423022106"}],"tags":{"Specialist":["Cancer - Oncologist","Vascular Medicine"],"Disease Category":["Cancer","Congenital Abnormality"]},"synonyms":["angiosarcoma (disease)"," blood vessel sarcoma"," hemangioendothelial sarcoma"," hemangioendothelioma, malignant"," hemangiosarcoma"," hemangiosarcoma, malignant"," malignant angioendothelioma"," malignant hemangioendothelioma"," sarcoma of blood vessel"," vascular sarcoma"]}