{"Name":"Hemolytic-uremic syndrome","DiseaseID__c":"GARD:0022233","id":22233,"encodedName":"hemolytic-uremic-syndrome","IsDeleted":false,"Disease_Name_Full__c":"Hemolytic-uremic syndrome","Xref_IDs__c":"111407006; C0019061; C75545; D006463; D59.3; DOID:12554; HP:0005575; MEDGEN:42403; MONDO:0001549; ORPHA:544458","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":1,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":1,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":1,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":3,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0001549","Disease_Description__c":"Acute kidney injury associated with microangiopathic hemolytic anemia and thrombocytopenia.","GARD_Name__c":"Hemolytic-uremic syndrome","GARD_Synonym__c":"gasser's syndrome; haemolytic-uraemic syndrome; hemolytic uremic syndrome; hus; hus - hemolytic uremic syndrome","Curated_Disease_Description_Source__c":"MONDO:0001549","Curated_Disease_Description__c":"Hemolytic uremic syndrome, or HUS, is a kidney condition that happens when red blood cells are destroyed and block the kidneys' filtering system. Red blood cells contain hemoglobin—an iron-rich protein that gives blood its red color and carries oxygen from the lungs to all parts of the body.\r\n\r\nWhen the kidneys and glomeruli—the tiny units within the kidneys where blood is filtered—become clogged with the damaged red blood cells, they are unable to do their jobs. If the kidneys stop functioning, a child can develop acute kidney injury—the sudden and temporary loss of kidney function. Hemolytic uremic syndrome is the most common cause of acute kidney injury in children.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":"ORPHA:544458","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0001549","ORPHANET_ID__c":"ORPHA:544458","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Síndrome hemolítico urémico","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"síndrome hemolítico urémico","Spanish_GARD_Synonym__c":"shu","Category_Linearization__c":"ORPHA:93626","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Hemolytic uremic syndrome, or HUS, is a kidney condition that happens when red blood cells are destroyed and block the kidneys' filtering system. Red blood cells contain hemoglobin—an iron-rich protein that gives blood its red color and carries oxygen from the lungs to all parts of the body.\r\n\r\nWhen the kidneys and glomeruli—the tiny units within the kidneys where blood is filtered—become clogged with the damaged red blood cells, they are unable to do their jobs. If the kidneys stop functioning, a child can develop acute kidney injury—the sudden and temporary loss of kidney function. Hemolytic uremic syndrome is the most common cause of acute kidney injury in children.","Curated_Disease_Description_Source__c":"MONDO:0001549","GARD_Synonym__c":"gasser's syndrome; haemolytic-uraemic syndrome; hemolytic uremic syndrome; hus; hus - hemolytic uremic syndrome","Name":"Hemolytic-uremic syndrome","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Nephrology","Tag_Category__c":"Account;Disease Category;Specialist","category_description":"Kidney diseases affect the kidneys' ability to remove waste and water from blood, create urine, or make certain hormones.","curated_tag_name":"Kidney diseases"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.orpha.net/en/disease/detail/544458","Source__c":"C0019061; MONDO:0001549; ORPHA:544458","Xref__c":"ORPHA:544458"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=42403","Source__c":"C0019061","Xref__c":"MEDGEN:42403"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C006463","Source__c":"C0019061; MONDO:0001549","Xref__c":"D006463"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=111407006","Source__c":"C0019061; MONDO:0001549","Xref__c":"111407006"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/D59.3","Source__c":"MONDO:0001549","Xref__c":"D59.3"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0019061","Source__c":"C0019061","Xref__c":"C0019061"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A12554","Source__c":"MONDO:0001549","Xref__c":"DOID:12554"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C75545","Source__c":"C0019061; MONDO:0001549","Xref__c":"C75545"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0001549","Source__c":"GARD:0022233","Xref__c":"MONDO:0001549"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0005575","Source__c":"C0019061","Xref__c":"HP:0005575"},{"URL__c":"https://www.niddk.nih.gov/health-information/kidney-disease/children/hemolytic-uremic-syndrome"}],"tags":{"Account":["Nephrology"],"Disease Category":["Nephrology"],"Specialist":["Nephrology"]},"synonyms":["gasser's syndrome"," haemolytic-uraemic syndrome"," hemolytic uremic syndrome"," hus"," hus - hemolytic uremic syndrome"]}