{"Name":"Paraganglioma","DiseaseID__c":"GARD:0022770","id":22770,"encodedName":"paraganglioma","IsDeleted":false,"Disease_Name_Full__c":"Paraganglioma","Xref_IDs__c":"127027008; 302833002; 803009; C0030421; C3308; D010235; DOID:0050773; HP:0002668; MEDGEN:10571; MONDO:0000448","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":1,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":1,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":1,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0000448","Disease_Description__c":"A benign or malignant neoplasm arising from paraganglia located along the sympathetic or parasympathetic nerves. Infrequently, it may arise outside the usual distribution of the sympathetic and parasympathetic paraganglia. Tumors arising from the adrenal gland medulla are called pheochromocytomas. Morphologically, paragangliomas usually display a nesting (Zellballen) growth pattern. There are no reliable morphologic criteria to distinguish between benign and malignant paragangliomas. The only definitive indicator of malignancy is the presence of regional or distant metastases.","GARD_Name__c":"Paraganglioma","GARD_Synonym__c":"carotid body tumor; carotid body tumors; carotid body tumours; gangliocytic paraganglioma; neoplasm of paraganglion; neoplasm of the paraganglion; paragangliomas; paraganglion neoplasm; paraganglion tumor; paraganglion tumour; paraganglionic neoplasm; paraganglionic tumor; paraganglionic tumour; tumor of paraganglion; tumor of the paraganglion; tumour of paraganglion; tumour of the paraganglion","Curated_Disease_Description_Source__c":"MONDO:0000448","Curated_Disease_Description__c":"A benign or malignant neoplasm arising from paraganglia located along the sympathetic or parasympathetic nerves. Infrequently, it may arise outside the usual distribution of the sympathetic and parasympathetic paraganglia. Tumors arising from the adrenal gland medulla are called pheochromocytomas. Morphologically, paragangliomas usually display a nesting (Zellballen) growth pattern. There are no reliable morphologic criteria to distinguish between benign and malignant paragangliomas. The only definitive indicator of malignancy is the presence of regional or distant metastases.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0000448","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A benign or malignant neoplasm arising from paraganglia located along the sympathetic or parasympathetic nerves. Infrequently, it may arise outside the usual distribution of the sympathetic and parasympathetic paraganglia. Tumors arising from the adrenal gland medulla are called pheochromocytomas. Morphologically, paragangliomas usually display a nesting (Zellballen) growth pattern. There are no reliable morphologic criteria to distinguish between benign and malignant paragangliomas. The only definitive indicator of malignancy is the presence of regional or distant metastases.","Curated_Disease_Description_Source__c":"MONDO:0000448","GARD_Synonym__c":"carotid body tumor; carotid body tumors; carotid body tumours; gangliocytic paraganglioma; neoplasm of paraganglion; neoplasm of the paraganglion; paragangliomas; paraganglion neoplasm; paraganglion tumor; paraganglion tumour; paraganglionic neoplasm; paraganglionic tumor; paraganglionic tumour; tumor of paraganglion; tumor of the paraganglion; tumour of paraganglion; tumour of the paraganglion","Name":"Paraganglioma","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"}],"External_Identifier_Disease__c":[{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3308","Source__c":"C0030421; MONDO:0000448","Xref__c":"C3308"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0050773","Source__c":"MONDO:0000448","Xref__c":"DOID:0050773"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=10571","Source__c":"C0030421","Xref__c":"MEDGEN:10571"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=127027008","Source__c":"C0030421; MONDO:0000448","Xref__c":"127027008"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0030421","Source__c":"C0030421","Xref__c":"C0030421"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C010235","Source__c":"C0030421; MONDO:0000448","Xref__c":"D010235"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0000448","Source__c":"GARD:0022770","Xref__c":"MONDO:0000448"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=72787006","Source__c":"C0030421","Xref__c":"72787006"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=803009","Source__c":"C0030421","Xref__c":"803009"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=302833002","Source__c":"C0030421","Xref__c":"302833002"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0002668","Source__c":"C0030421","Xref__c":"HP:0002668"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=253029009","Source__c":"C0030421","Xref__c":"253029009"},{"URL__c":"https://www.cancer.gov/types/pheochromocytoma"}],"tags":{"Disease Category":["Cancer"]},"synonyms":["carotid body tumor"," carotid body tumors"," carotid body tumours"," gangliocytic paraganglioma"," neoplasm of paraganglion"," neoplasm of the paraganglion"," paragangliomas"," paraganglion neoplasm"," paraganglion tumor"," paraganglion tumour"," paraganglionic neoplasm"," paraganglionic tumor"," paraganglionic tumour"," tumor of paraganglion"," tumor of the paraganglion"," tumour of paraganglion"," tumour of the paraganglion"]}