{"Name":"Childhood germ cell brain tumor","DiseaseID__c":"GARD:0023883","id":23883,"encodedName":"childhood-germ-cell-brain-tumor","IsDeleted":false,"Disease_Name_Full__c":"Childhood germ cell brain tumor","Xref_IDs__c":"C1377598; C5795; DOID:7430; MEDGEN:277987; MONDO:0004218","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":1,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":1,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":1,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0004218","Disease_Description__c":"A germ cell tumor arising from brain during childhood.","GARD_Name__c":"Childhood germ cell brain tumor","GARD_Synonym__c":"brain germ cell tumor; brain germ cell tumour; childhood brain germ cell neoplasm; childhood brain germ cell tumor; childhood brain germ cell tumour; childhood germ cell brain neoplasm; germ cell neoplasm of childhood brain; germ cell neoplasm of paediatric brain; germ cell neoplasm of pediatric brain; germ cell neoplasm of the childhood brain; germ cell neoplasm of the paediatric brain; germ cell neoplasm of the pediatric brain; germ cell tumor of childhood brain; germ cell tumor of pediatric brain; germ cell tumor of the childhood brain; germ cell tumor of the pediatric brain; germ cell tumour of childhood brain; germ cell tumour of paediatric brain; germ cell tumour of the childhood brain; germ cell tumour of the paediatric brain; paediatric brain germ cell neoplasm; paediatric brain germ cell tumour; pediatric brain germ cell neoplasm; pediatric brain germ cell tumor","Curated_Disease_Description_Source__c":"MONDO:0004218","Curated_Disease_Description__c":"Germ cells are the reproductive cells in a fetus. These cells later become sperm in the testicles or unfertilized eggs in the ovaries. Sometimes the germ cells travel to or from other parts of the fetus as it develops and later become germ cell tumors. Most germ cell tumors form in the testes or ovaries. Germ cell tumors that form in the brain or spinal cord are called CNS (central nervous system) germ cell tumors.\r\n\r\nCNS germ cell tumors occur most often in young people aged 10 to 19 years. They are more common in males than in females. In older children, CNS germ cell tumors usually form in the brain near the pineal gland and in an area of the brain that includes the pituitary gland and the tissue just above it. Sometimes germ cell tumors form in other areas of the brain.\r\nThe cause of most childhood CNS germ cell tumors is not known.\r\n\r\nGerm cell tumors may also form in other parts of the body. \r\nTreatment of CNS germ cell tumors may be different for children and adults. \r\nDifferent types of CNS germ cell tumors can form from the germ cells that later become sperm or unfertilized eggs. The type of CNS germ cell tumor that is diagnosed depends on what the cells look like under a microscope and results of laboratory tests that check tumor marker levels.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0004218","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Germ cells are the reproductive cells in a fetus. These cells later become sperm in the testicles or unfertilized eggs in the ovaries. Sometimes the germ cells travel to or from other parts of the fetus as it develops and later become germ cell tumors. Most germ cell tumors form in the testes or ovaries. Germ cell tumors that form in the brain or spinal cord are called CNS (central nervous system) germ cell tumors.\r\n\r\nCNS germ cell tumors occur most often in young people aged 10 to 19 years. They are more common in males than in females. In older children, CNS germ cell tumors usually form in the brain near the pineal gland and in an area of the brain that includes the pituitary gland and the tissue just above it. Sometimes germ cell tumors form in other areas of the brain.\r\nThe cause of most childhood CNS germ cell tumors is not known.\r\n\r\nGerm cell tumors may also form in other parts of the body. \r\nTreatment of CNS germ cell tumors may be different for children and adults. \r\nDifferent types of CNS germ cell tumors can form from the germ cells that later become sperm or unfertilized eggs. The type of CNS germ cell tumor that is diagnosed depends on what the cells look like under a microscope and results of laboratory tests that check tumor marker levels.","Curated_Disease_Description_Source__c":"MONDO:0004218","GARD_Synonym__c":"brain germ cell tumor; brain germ cell tumour; childhood brain germ cell neoplasm; childhood brain germ cell tumor; childhood brain germ cell tumour; childhood germ cell brain neoplasm; germ cell neoplasm of childhood brain; germ cell neoplasm of paediatric brain; germ cell neoplasm of pediatric brain; germ cell neoplasm of the childhood brain; germ cell neoplasm of the paediatric brain; germ cell neoplasm of the pediatric brain; germ cell tumor of childhood brain; germ cell tumor of pediatric brain; germ cell tumor of the childhood brain; germ cell tumor of the pediatric brain; germ cell tumour of childhood brain; germ cell tumour of paediatric brain; germ cell tumour of the childhood brain; germ cell tumour of the paediatric brain; paediatric brain germ cell neoplasm; paediatric brain germ cell tumour; pediatric brain germ cell neoplasm; pediatric brain germ cell tumor","Name":"Childhood germ cell brain tumor","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=277987","Source__c":"C1377598","Xref__c":"MEDGEN:277987"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C5795","Source__c":"C1377598; MONDO:0004218","Xref__c":"C5795"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A7430","Source__c":"MONDO:0004218","Xref__c":"DOID:7430"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1377598","Source__c":"C1377598","Xref__c":"C1377598"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0004218","Source__c":"GARD:0023883","Xref__c":"MONDO:0004218"},{"URL__c":"https://www.cancer.gov/types/brain"}],"tags":{"Disease Category":["Cancer"]},"synonyms":["brain germ cell tumor"," brain germ cell tumour"," childhood brain germ cell neoplasm"," childhood brain germ cell tumor"," childhood brain germ cell tumour"," childhood germ cell brain neoplasm"," germ cell neoplasm of childhood brain"," germ cell neoplasm of paediatric brain"," germ cell neoplasm of pediatric brain"," germ cell neoplasm of the childhood brain"," germ cell neoplasm of the paediatric brain"," germ cell neoplasm of the pediatric brain"," germ cell tumor of childhood brain"," germ cell tumor of pediatric brain"," germ cell tumor of the childhood brain"," germ cell tumor of the pediatric brain"," germ cell tumour of childhood brain"," germ cell tumour of paediatric brain"," germ cell tumour of the childhood brain"," germ cell tumour of the paediatric brain"," paediatric brain germ cell neoplasm"," paediatric brain germ cell tumour"," pediatric brain germ cell neoplasm"," pediatric brain germ cell tumor"]}