{"Name":"Malignant pleural mesothelioma","DiseaseID__c":"GARD:0024150","id":24150,"encodedName":"malignant-pleural-mesothelioma","IsDeleted":false,"Disease_Name_Full__c":"Malignant pleural mesothelioma","Xref_IDs__c":"254645002; 423022275; C0812413; C7376; DOID:7474; MEDGEN:208810; MONDO:0005112","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":1,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":1,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0005112","Disease_Description__c":"A malignant neoplasm that arises from mesothelial cells in the pleura and shows a diffuse growth pattern. It arises on the parietal and sometimes visceral pleura as multiple small nodules that later become confluent and invade the chest wall adipose tissue and muscle. Asbestos exposure is the main cause for the development of pleural malignant mesothelioma. It usually affects patients over sixty years of age. The latency period is long. Patients usually present with pleural effusion, dyspnea and chest wall pain. Additional signs and symptoms include chills, sweating, weight loss, and weakness. Morphologic variants include epithelioid, desmoplastic, sarcomatoid, and biphasic mesothelioma. The clinical course is usually aggressive.","GARD_Name__c":"Malignant pleural mesothelioma","GARD_Synonym__c":"malignant mesothelioma of pleura; malignant mesothelioma of the pleura; pleural diffuse malignant mesothelioma; pleural malignant mesothelioma","Curated_Disease_Description_Source__c":"MONDO:0005112","Curated_Disease_Description__c":"Pleural mesothelioma is a rare type of cancer where malignant cells are found in the pleura (the thin layer of tissue that lines the chest cavity and covers the lungs). Exposure to airborne asbestos particles increases one's risk of developing malignant mesothelioma. Although reported incidence rates have increased in the past 20 years, pleural mesothelioma is still a relatively rare cancer. About 2,000 new cases of pleural mesothelioma are diagnosed in the United States each year. Pleural mesothelioma occurs more often in men than in women and risk increases with age, but this disease can appear in either men or women at any age. Working with asbestos is the major risk factor for mesothelioma. A history of asbestos exposure at work is reported in about 70% to 80% of all cases. However, mesothelioma has been reported in some individuals without any known exposure to asbestos.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0005112","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Pleural mesothelioma is a rare type of cancer where malignant cells are found in the pleura (the thin layer of tissue that lines the chest cavity and covers the lungs). Exposure to airborne asbestos particles increases one's risk of developing malignant mesothelioma. Although reported incidence rates have increased in the past 20 years, pleural mesothelioma is still a relatively rare cancer. About 2,000 new cases of pleural mesothelioma are diagnosed in the United States each year. Pleural mesothelioma occurs more often in men than in women and risk increases with age, but this disease can appear in either men or women at any age. Working with asbestos is the major risk factor for mesothelioma. A history of asbestos exposure at work is reported in about 70% to 80% of all cases. However, mesothelioma has been reported in some individuals without any known exposure to asbestos.","Curated_Disease_Description_Source__c":"MONDO:0005112","GARD_Synonym__c":"malignant mesothelioma of pleura; malignant mesothelioma of the pleura; pleural diffuse malignant mesothelioma; pleural malignant mesothelioma","Name":"Malignant pleural mesothelioma","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Mesothelioma Guide","Website__c":"https://www.mesotheliomaguide.com/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0812413","Source__c":"C0812413","Xref__c":"C0812413"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C7376","Source__c":"C0812413; MONDO:0005112","Xref__c":"C7376"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A7474","Source__c":"MONDO:0005112","Xref__c":"DOID:7474"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=254645002","Source__c":"C0812413; MONDO:0005112","Xref__c":"254645002"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=208810","Source__c":"C0812413","Xref__c":"MEDGEN:208810"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0100002","Source__c":"C0812413","Xref__c":"HP:0100002"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0005112","Source__c":"GARD:0024150","Xref__c":"MONDO:0005112"},{"URL__c":"https://secure.ssa.gov/apps10/poms.nsf/lnx/0423022275","Xref__c":"423022275"}],"tags":{"Disease Category":["Cancer"]},"synonyms":["malignant mesothelioma of pleura"," malignant mesothelioma of the pleura"," pleural diffuse malignant mesothelioma"," pleural malignant mesothelioma"]}