{"Name":"Carcinoid tumor","DiseaseID__c":"GARD:0024176","id":24176,"encodedName":"carcinoid-tumor","IsDeleted":false,"Disease_Name_Full__c":"Carcinoid tumor","Xref_IDs__c":"443492008; C0007095; D002276; HP:0100570; MEDGEN:2838; MONDO:0005369","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":1,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":1,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0005369","Disease_Description__c":"A slow growing neuroendocrine tumor, composed of uniform, round, or polygonal cells having monotonous, centrally located nuclei and small nucleoli, infrequent mitoses, and no necrosis. The tumor may show a variety of patterns, such as solid, trabecular, and acinar. Electron microscopy shows small secretory granules. Immunohistochemical studies reveal NSE, as well as chromogranin immunoreactivity. Malignant histology (cellular pleomorphism, hyperchromatic nuclei, prominent nucleoli, necrosis, and mitoses) can occasionally be seen. Such cases may have an aggressive clinical course. Gastrointestinal tract and lung are common sites of involvement.","GARD_Name__c":"Carcinoid tumor","GARD_Synonym__c":"carcinoid; carcinoid tumor (disease); carcinoid tumors; carcinoid tumour; carcinoid tumour (disease); carcinoid tumours; net g1; neuroendocrine neoplasm g1; neuroendocrine tumor g1; neuroendocrine tumour g1","Curated_Disease_Description_Source__c":"MONDO:0005369","Curated_Disease_Description__c":"Carcinoid tumors are rare, slow-growing cancers. They usually start in the lining of the digestive tract or in the lungs. They grow slowly and don't produce symptoms in the early stages. As a result, the average age of people diagnosed with digestive or lung carcinoids is about 60.\r\n\r\nIn later stages the tumors sometimes produce hormones that can cause carcinoid syndrome. The syndrome causes flushing of the face and upper chest, diarrhea, and trouble breathing.\r\n\r\nSurgery is the main treatment for carcinoid tumors. If they haven't spread to other parts of the body, surgery can cure the cancer.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0005369","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Carcinoid tumors are rare, slow-growing cancers. They usually start in the lining of the digestive tract or in the lungs. They grow slowly and don't produce symptoms in the early stages. As a result, the average age of people diagnosed with digestive or lung carcinoids is about 60.\r\n\r\nIn later stages the tumors sometimes produce hormones that can cause carcinoid syndrome. The syndrome causes flushing of the face and upper chest, diarrhea, and trouble breathing.\r\n\r\nSurgery is the main treatment for carcinoid tumors. If they haven't spread to other parts of the body, surgery can cure the cancer.","Curated_Disease_Description_Source__c":"MONDO:0005369","GARD_Synonym__c":"carcinoid; carcinoid tumor (disease); carcinoid tumors; carcinoid tumour; carcinoid tumour (disease); carcinoid tumours; net g1; neuroendocrine neoplasm g1; neuroendocrine tumor g1; neuroendocrine tumour g1","Name":"Carcinoid tumor","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"American Cancer Society","Website__c":"https://www.cancer.org"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0007095","Source__c":"C0007095","Xref__c":"C0007095"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=2838","Source__c":"C0007095","Xref__c":"MEDGEN:2838"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=443492008","Source__c":"MONDO:0005369","Xref__c":"443492008"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C002276","Source__c":"C0007095; MONDO:0005369","Xref__c":"D002276"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0005369","Source__c":"GARD:0024176","Xref__c":"MONDO:0005369"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0100570","Source__c":"C0007095","Xref__c":"HP:0100570"},{"URL__c":"https://medlineplus.gov/carcinoidtumors.html"}],"tags":{"Disease Category":["Cancer"]},"synonyms":["carcinoid"," carcinoid tumor (disease)"," carcinoid tumors"," carcinoid tumour"," carcinoid tumour (disease)"," carcinoid tumours"," net g1"," neuroendocrine neoplasm g1"," neuroendocrine tumor g1"," neuroendocrine tumour g1"]}