{"Name":"Fused mandibular incisors","DiseaseID__c":"GARD:0002419","id":2419,"encodedName":"fused-mandibular-incisors","IsDeleted":false,"Disease_Name_Full__c":"Fused mandibular incisors","Xref_IDs__c":"707796002; C3494175; MEDGEN:488128; MONDO:0007820; OMIM:147251; ORPHA:2287","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":6,"No_of_Age_at_Onset__c":3,"Description_Source__c":"MONDO:0007820","Disease_Description__c":"Fused manidbular incisors is an extremely rare dental anomaly that is characterized by the union of two, normally separated, incisor tooth germs of the primary dentition. It is frequently associated with hypodontia (see this term) and an increased risk of pulp exposure.","GARD_Name__c":"Fused mandibular incisors","GARD_Synonym__c":"\"double tooth\"; fusion of mandibular incisor teeth","Curated_Disease_Description_Source__c":"MONDO:0007820","Curated_Disease_Description__c":"Fused manidbular incisors is an extremely rare dental anomaly that is characterized by the union of two, normally separated, incisor tooth germs of the primary dentition. It is frequently associated with hypodontia (see this term) and an increased risk of pulp exposure.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"from Childhood to Adulthood","SourceID__c":"ORPHA:2287","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0007820","ORPHANET_ID__c":"ORPHA:2287","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Fusión de incisivos mandibulares","Spanish_Description_Source__c":"ORPHA:2287","Spanish_Description__c":"La fusión de incisivos mandibulares es una anomalía dental extremadamente rara que se caracteriza por la unión de los gérmenes de dos dientes incisivos de la primera dentición normalmente separados. Frecuentemente está asociado con hipodoncia (ver este término) y un mayor riesgo de exposición pulpar.","Spanish_Disease_Name__c":"fusión de incisivos mandibulares","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:98026","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Fused manidbular incisors is an extremely rare dental anomaly that is characterized by the union of two, normally separated, incisor tooth germs of the primary dentition. It is frequently associated with hypodontia (see this term) and an increased risk of pulp exposure.","Curated_Disease_Description_Source__c":"MONDO:0007820","GARD_Synonym__c":"\"double tooth\"; fusion of mandibular incisor teeth","Name":"Fused mandibular incisors","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Genetics","Tag_Category__c":"Cause;Disease Category;Specialist","category_description":"Genetic diseases affect the DNA, or genetic instructions, which directs how tissues, organs, and body systems function.","curated_tag_name":"Genetic diseases"},{"Tag_Name__c":"Odontology","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Childhood","Provided_By__c":"ORPHA:2287"},{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:2287"},{"Age_At_Onset__c":"Adolescent","Provided_By__c":"ORPHA:2287"}],"External_Identifier_Disease__c":[{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=707796002","Source__c":"C3494175; MONDO:0007820","Xref__c":"707796002"},{"URL__c":"https://www.orpha.net/en/disease/detail/2287","Source__c":"C3494175; MONDO:0007820; ORPHA:2287","Xref__c":"ORPHA:2287"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C3494175","Source__c":"C3494175","Xref__c":"C3494175"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=488128","Source__c":"C3494175","Xref__c":"MEDGEN:488128"},{"URL__c":"https://www.omim.org/entry/147251","Source__c":"C3494175; MONDO:0007820; ORPHA:2287","Xref__c":"OMIM:147251"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0007820","Source__c":"GARD:0002419","Xref__c":"MONDO:0007820"}],"Inheritance__c":["Autosomal dominant"],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:2287","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Any abnormality of the teeth.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000164","HPO_Synonym__c":"Abnormal dentition; Abnormal teeth; Dental abnormalities; Dental abnormality; Dental anomalies","HPO_Name__c":"Abnormality of the dentition","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:2287","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Premature tooth eruption, which can be defined as tooth eruption more than 2 SD earlier than the mean eruption age.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0006288","HPO_Synonym__c":"Advanced dental eruption; Advanced tooth eruption; Early dental eruption; Early eruption of teeth; Eruption, advanced; Premature dental eruption; Premature eruption of teeth; Premature tooth eruption","HPO_Name__c":"Advanced eruption of teeth","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Cause":["Genetics"],"Disease Category":["Genetics"],"Specialist":["Genetics","Odontology","Pediatrics"]},"synonyms":["\"double tooth\""," fusion of mandibular incisor teeth"]}