{"Name":"Ganglioglioma","DiseaseID__c":"GARD:0002430","id":2430,"encodedName":"ganglioglioma","IsDeleted":false,"Disease_Name_Full__c":"Ganglioglioma","Xref_IDs__c":"1162662003; 87191000119100; C0206716; C3788; D018303; DOID:5078; HP:0033664; MEDGEN:60216; MONDO:0016733; ORPHA:251949","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":3,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0016733","Disease_Description__c":"A well differentiated, slow growing neuroepithelial neoplasm composed of neoplastic, mature ganglion cells and neoplastic glial cells. Some gangliogliomas show anaplastic features in their glial component and are considered to be WHO grade III. Rare cases of newly diagnosed gangliogliomas with grade IV (glioblastoma) changes in the glial component have also been reported. (Adapted from WHO)","GARD_Name__c":"Ganglioglioma","GARD_Synonym__c":"cns ganglioglioma; glioneuroma; mixed cell tumors containing both neural ganglionic cells and neural glial cell components; neuroastrocytoma","Curated_Disease_Description_Source__c":"GARD:0002430","Curated_Disease_Description__c":"A Ganglioglioma is a rare type of brain tumor, accounting for approximately 1% of all brain tumors. Gangliogliomas occur when a single cell in the brain starts to divide into more cells, forming a tumor. This can occur when the cell randomly acquires changes in genes that regulate how a cell divides. Most Gangliogliomas grow slowly and are considered benign. However, up to 10% of Gangliogliomas may grow more rapidly and become malignant, meaning the tumor affects the surrounding brain tissue.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":"ORPHA:251949","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0016733","ORPHANET_ID__c":"ORPHA:251949","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Ganglioglioma","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"ganglioglioma","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A Ganglioglioma is a rare type of brain tumor, accounting for approximately 1% of all brain tumors. Gangliogliomas occur when a single cell in the brain starts to divide into more cells, forming a tumor. This can occur when the cell randomly acquires changes in genes that regulate how a cell divides. Most Gangliogliomas grow slowly and are considered benign. However, up to 10% of Gangliogliomas may grow more rapidly and become malignant, meaning the tumor affects the surrounding brain tissue.","Curated_Disease_Description_Source__c":"GARD:0002430","GARD_Synonym__c":"cns ganglioglioma; glioneuroma; mixed cell tumors containing both neural ganglionic cells and neural glial cell components; neuroastrocytoma","Name":"Ganglioglioma","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Pediatric Brain Tumor Foundation","Website__c":"https://www.curethekids.org/"},{"Account_Name__c":"Alex's Lemonade Stand Foundation","Website__c":"https://www.alexslemonade.org/"},{"Account_Name__c":"Brain Foundation","Website__c":"http://www.brainfoundation.org.au/"},{"Account_Name__c":"American Brain Tumor Association","Website__c":"https://www.abta.org/"},{"Account_Name__c":"National Brain Tumor Society","Website__c":"https://braintumor.org/"},{"Account_Name__c":"International Brain Tumour Alliance","Website__c":"https://theibta.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.orpha.net/en/disease/detail/251949","Source__c":"C0206716; MONDO:0016733; ORPHA:251949","Xref__c":"ORPHA:251949"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=60216","Source__c":"C0206716","Xref__c":"MEDGEN:60216"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A5078","Source__c":"MONDO:0016733","Xref__c":"DOID:5078"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3788","Source__c":"C0206716; MONDO:0016733","Xref__c":"C3788"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=87191000119100","Source__c":"C0206716; MONDO:0016733","Xref__c":"87191000119100"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0206716","Source__c":"C0206716","Xref__c":"C0206716"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C018303","Source__c":"C0206716; MONDO:0016733","Xref__c":"D018303"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0016733","Source__c":"GARD:0002430","Xref__c":"MONDO:0016733"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=1162662003","Source__c":"C0206716","Xref__c":"1162662003"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0033664","Source__c":"C0206716","Xref__c":"HP:0033664"}],"tags":{"Specialist":["Cancer - Oncologist","Neurology"],"Disease Category":["Cancer","Neurology"]},"synonyms":["cns ganglioglioma"," glioneuroma"," mixed cell tumors containing both neural ganglionic cells and neural glial cell components"," neuroastrocytoma"]}