{"Name":"Myelodysplastic/myeloproliferative neoplasm","DiseaseID__c":"GARD:0024368","id":24368,"encodedName":"myelodysplasticmyeloproliferative-neoplasm","IsDeleted":false,"Disease_Name_Full__c":"Myelodysplastic/myeloproliferative neoplasm","Xref_IDs__c":"445738007; C1301355; C27262; DOID:4972; MEDGEN:226981; MONDO:0006311","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":1,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":1,"No_of_Disease_Descriptions__c":1,"Disease_Characteristics_Score__c":1,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0006311","Disease_Description__c":"A category of clonal hematopoietic disorders that have both myelodysplastic and myeloproliferative features at the time of initial presentation.","GARD_Name__c":"Myelodysplastic/myeloproliferative neoplasm","GARD_Synonym__c":"mds/mpn; mpd-mds; mpd/mds; myelodysplastic myeloproliferative cancer; myelodysplastic-myeloproliferative neoplasm; myelodysplastic/myeloproliferative neoplasms","Curated_Disease_Description_Source__c":"MONDO:0006311","Curated_Disease_Description__c":"Myelodysplastic/myeloproliferative neoplasms are diseases of the blood and bone marrow.\r\n\r\nNormally, the bone marrow makes blood stem cells (immature cells) that become mature blood cells over time. A blood stem cell may become a myeloid stem cell or a lymphoid stem cell. A lymphoid stem cell becomes a white blood cell. A myeloid stem cell becomes one of three types of mature blood cells: 1) red blood cells that carry oxygen and other substances to all tissues of the body 2) granulocytes and other types of white blood cells that help the body's immune system respond to infection, allergens, and inflammation and 3) platelets that help stop bleeding by forming clots.\r\n\r\nThe two main types of myelodysplastic/myeloproliferative neoplasms in adults include: 1) chronic myelomonocytic leukemia (CMML) and 2) atypical chronic myeloid leukemia (CML).\r\n\r\nWhen a myelodysplastic/myeloproliferative neoplasm does not match any of these types, it is called myelodysplastic/myeloproliferative neoplasm, unclassifiable (MDS/MPN-UC).\r\n\r\nMyelodysplastic/myeloproliferative neoplasms may progress to acute leukemia.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0006311","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Myelodysplastic/myeloproliferative neoplasms are diseases of the blood and bone marrow.\r\n\r\nNormally, the bone marrow makes blood stem cells (immature cells) that become mature blood cells over time. A blood stem cell may become a myeloid stem cell or a lymphoid stem cell. A lymphoid stem cell becomes a white blood cell. A myeloid stem cell becomes one of three types of mature blood cells: 1) red blood cells that carry oxygen and other substances to all tissues of the body 2) granulocytes and other types of white blood cells that help the body's immune system respond to infection, allergens, and inflammation and 3) platelets that help stop bleeding by forming clots.\r\n\r\nThe two main types of myelodysplastic/myeloproliferative neoplasms in adults include: 1) chronic myelomonocytic leukemia (CMML) and 2) atypical chronic myeloid leukemia (CML).\r\n\r\nWhen a myelodysplastic/myeloproliferative neoplasm does not match any of these types, it is called myelodysplastic/myeloproliferative neoplasm, unclassifiable (MDS/MPN-UC).\r\n\r\nMyelodysplastic/myeloproliferative neoplasms may progress to acute leukemia.","Curated_Disease_Description_Source__c":"MONDO:0006311","GARD_Synonym__c":"mds/mpn; mpd-mds; mpd/mds; myelodysplastic myeloproliferative cancer; myelodysplastic-myeloproliferative neoplasm; myelodysplastic/myeloproliferative neoplasms","Name":"Myelodysplastic/myeloproliferative neoplasm","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=226981","Source__c":"C1301355","Xref__c":"MEDGEN:226981"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=445738007","Source__c":"C1301355; MONDO:0006311","Xref__c":"445738007"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A4972","Source__c":"MONDO:0006311","Xref__c":"DOID:4972"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1301355","Source__c":"C1301355","Xref__c":"C1301355"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C27262","Source__c":"C1301355; MONDO:0006311","Xref__c":"C27262"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C054437","Source__c":"C1301355","Xref__c":"D054437"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=397336008","Source__c":"C1301355","Xref__c":"397336008"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0006311","Source__c":"GARD:0024368","Xref__c":"MONDO:0006311"},{"URL__c":"https://www.cancer.gov/types/myeloproliferative/patient/mds-mpd-treatment-pdq"}],"tags":{"Disease Category":["Cancer"]},"synonyms":["mds/mpn"," mpd-mds"," mpd/mds"," myelodysplastic myeloproliferative cancer"," myelodysplastic-myeloproliferative neoplasm"," myelodysplastic/myeloproliferative neoplasms"]}