{"Name":"Acute leukemia","DiseaseID__c":"GARD:0024743","id":24743,"encodedName":"acute-leukemia","IsDeleted":false,"Disease_Name_Full__c":"Acute leukemia","Xref_IDs__c":"24072005; 423022085; 91855006; C0085669; C564112; C9300; DOID:12603; HP:0002488; MEDGEN:43225; MONDO:0010643","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":1,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":1,"No_of_Disease_Descriptions__c":1,"Disease_Characteristics_Score__c":1,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0010643","Disease_Description__c":"A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).","GARD_Name__c":"Acute leukemia","GARD_Synonym__c":"acute blood cancer; acute leukaemia; acute leukaemia (disease); acute leukemia (disease); acute leukemia, disease; acute leukemia, morphology, including blast cell or undifferentiated leukemia; acute leukemias","Curated_Disease_Description_Source__c":"MONDO:0010643","Curated_Disease_Description__c":"Acute leukemia is a rapidly progressing cancer that starts in the blood-forming tissue such as the bone marrow, and causes large numbers of white blood cells to be produced and enter the blood stream. White blood cells fight infection and are generally classified as lymphocytes or as myelocytes depending on their exact form and function. If the growth of the white blood cells involves the lymphoid line, the disease is classified as acute lymphocytic leukemia; that of the myeloid line is classified as acute myeloid leukemia.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0010643","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Acute leukemia is a rapidly progressing cancer that starts in the blood-forming tissue such as the bone marrow, and causes large numbers of white blood cells to be produced and enter the blood stream. White blood cells fight infection and are generally classified as lymphocytes or as myelocytes depending on their exact form and function. If the growth of the white blood cells involves the lymphoid line, the disease is classified as acute lymphocytic leukemia; that of the myeloid line is classified as acute myeloid leukemia.","Curated_Disease_Description_Source__c":"MONDO:0010643","GARD_Synonym__c":"acute blood cancer; acute leukaemia; acute leukaemia (disease); acute leukemia (disease); acute leukemia, disease; acute leukemia, morphology, including blast cell or undifferentiated leukemia; acute leukemias","Name":"Acute leukemia","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A12603","Source__c":"MONDO:0010643","Xref__c":"DOID:12603"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=91855006","Source__c":"C0085669; MONDO:0010643","Xref__c":"91855006"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=43225","Source__c":"C0085669","Xref__c":"MEDGEN:43225"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9300","Source__c":"C0085669; MONDO:0010643","Xref__c":"C9300"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C564112","Source__c":"MONDO:0010643","Xref__c":"C564112"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0085669","Source__c":"C0085669","Xref__c":"C0085669"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0010643","Source__c":"GARD:0024743","Xref__c":"MONDO:0010643"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=24072005","Source__c":"C0085669","Xref__c":"24072005"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0002488","Source__c":"C0085669","Xref__c":"HP:0002488"},{"URL__c":"https://secure.ssa.gov/apps10/poms.nsf/lnx/0423022085","Xref__c":"423022085"}],"tags":{"Disease Category":["Cancer"]},"synonyms":["acute blood cancer"," acute leukaemia"," acute leukaemia (disease)"," acute leukemia (disease)"," acute leukemia, disease"," acute leukemia, morphology, including blast cell or undifferentiated leukemia"," acute leukemias"]}