{"Name":"Cat scratch disease","DiseaseID__c":"GARD:0000027","id":27,"encodedName":"cat-scratch-disease","IsDeleted":false,"Disease_Name_Full__c":"Cat scratch disease","Xref_IDs__c":"79974007; A28.1; C0007361; C84620; D002372; DOID:11258; MEDGEN:2861; MONDO:0005692; ORPHA:50839","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":1,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":1,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0005692","Disease_Description__c":"Cat scratch disease is an infectious illness caused by the bacteria bartonella (Bartonella henselae). It is believed to be transmitted by cat scratches, bites, or exposure to cat saliva. This self-limiting infectious diseaseis characterized by a bump or blister at the site of the bite or scratch and swelling and pain in the lymph nodes. Other features may include fatigue, headache, achiness, and fever. Although cat-scratch disease usually subsides without treatment, antibiotic and/or antimicrobial therapy may help speed recovery.","GARD_Name__c":"Cat scratch disease","GARD_Synonym__c":"bartonellosis due to bartonella henselae infection; benign inoculation lymphoreticulosis; benign lymphoreticulosis; cat scratch fever; cat-scratch disease; cat-scratch fever; csd - cat scratch disease; debre-mollaret syndrome; debre's syndrome; foshay-mollaret cat scratch fever","Curated_Disease_Description_Source__c":"GARD:0000027","Curated_Disease_Description__c":"Cat scratch disease (CSD) is a bacterial infection that primarily affects the lymph nodes. It is typically caused by the bacteria bartonella (Bartonella henselae). It is usually transmitted by being scratched or bitten by a cat, but rarely, no scratch or bite is involved. Symptoms frequently include the formation of a small bump at the site of the scratch or bite, followed by fever and swollen lymph nodes (lymphadenopathy) within 1-3 weeks. People with weakened immune systems (and less commonly, people with healthy immune systems) may develop more widespread disease and additional symptoms or neurological complications, which can be severe. In most cases, particularly in children and adolescents, having CSD once means that it cannot occur again.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:50839","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0005692","ORPHANET_ID__c":"ORPHA:50839","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Enfermedad por arañazo de gato","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"enfermedad por arañazo de gato","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:68416","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Cat scratch disease (CSD) is a bacterial infection that primarily affects the lymph nodes. It is typically caused by the bacteria bartonella (Bartonella henselae). It is usually transmitted by being scratched or bitten by a cat, but rarely, no scratch or bite is involved. Symptoms frequently include the formation of a small bump at the site of the scratch or bite, followed by fever and swollen lymph nodes (lymphadenopathy) within 1-3 weeks. People with weakened immune systems (and less commonly, people with healthy immune systems) may develop more widespread disease and additional symptoms or neurological complications, which can be severe. In most cases, particularly in children and adolescents, having CSD once means that it cannot occur again.","Curated_Disease_Description_Source__c":"GARD:0000027","GARD_Synonym__c":"bartonellosis due to bartonella henselae infection; benign inoculation lymphoreticulosis; benign lymphoreticulosis; cat scratch fever; cat-scratch disease; cat-scratch fever; csd - cat scratch disease; debre-mollaret syndrome; debre's syndrome; foshay-mollaret cat scratch fever","Name":"Cat scratch disease","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Infectious Disease","Tag_Category__c":"Disease Category;Specialist","category_description":"Infectious diseases are caused by bacteria, viruses, fungi, or parasites entering the body, multiplying, and spreading illness.","curated_tag_name":"Infectious diseases"},{"Tag_Name__c":"Rare Bacterial Infectious Disease","Tag_Category__c":"Cause","curated_tag_name":"Bacterial Infectious Disease"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:50839"}],"External_Identifier_Disease__c":[{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C84620","Source__c":"C0007361; MONDO:0005692","Xref__c":"C84620"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=79974007","Source__c":"C0007361; MONDO:0005692","Xref__c":"79974007"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/A28.1","Source__c":"MONDO:0005692","Xref__c":"A28.1"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C002372","Source__c":"C0007361; MONDO:0005692","Xref__c":"D002372"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=2861","Source__c":"C0007361","Xref__c":"MEDGEN:2861"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0007361","Source__c":"C0007361","Xref__c":"C0007361"},{"URL__c":"https://www.orpha.net/en/disease/detail/50839","Source__c":"C0007361; MONDO:0005692; ORPHA:50839","Xref__c":"ORPHA:50839"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A11258","Source__c":"MONDO:0005692","Xref__c":"DOID:11258"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0005692","Source__c":"GARD:0000027","Xref__c":"MONDO:0005692"},{"URL__c":"https://medlineplus.gov/catscratchdisease.html"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Blockage of a branch of the retinal vein. It may present with sudden-onset of painless vision loss or visual field defect correlating to the area of perfusion of the obstructed vessels.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0020165","HPO_Synonym__c":"Branch retinal vein obstruction","HPO_Name__c":"Branch retinal vein occlusion","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Inflammation of a joint.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001369","HPO_Synonym__c":"Arthritis; Joint inflammation","HPO_Name__c":"Arthritis","Feature_System__c":"Musculoskeletal System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Reduction of total body weight.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001824","HPO_Synonym__c":"Loss of weight","HPO_Name__c":"Weight loss","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Inflammation of the optic nerve.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100653","HPO_Name__c":"Optic neuritis","Feature_System__c":"Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"A feeling of general discomfort, weakness, or lack of health.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0033834","HPO_Name__c":"Malaise","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Body temperature elevated above the normal range.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001945","HPO_Synonym__c":"Fever; Hyperthermia; Pyrexia","HPO_Name__c":"Fever","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Lack of desire to eat (loss of appetite).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002039","HPO_Synonym__c":"Anorexia; Deliberately not eating; Obsessive dieting; Refusing to eat","HPO_Name__c":"Anorexia","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Pain in muscle.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0003326","HPO_Synonym__c":"Muscle ache; Muscle pain","HPO_Name__c":"Myalgia","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An abnormal elevation of the C-reactive protein level in the blood circulation.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0011227","HPO_Synonym__c":"Elevated C-reactive protein level","HPO_Name__c":"Elevated circulating C-reactive protein concentration","HPO_Feature_Type__c":"Lab"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"Inflammation of the layers of tissue that cover the brain and spinal cord (meninges) and of the fluid-filled space between the meninges (subarachnoid space) when it is caused by disorders that are not infections or by drugs or vaccines.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0033430","HPO_Synonym__c":"Aseptic meningitis","HPO_Name__c":"Non-infectious meningitis","Feature_System__c":"Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"Osteomyelitis is an inflammatory process accompanied by bone destruction and caused by an infecting microorganism.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002754","HPO_Synonym__c":"Bone infection","HPO_Name__c":"Osteomyelitis","Feature_System__c":"Musculoskeletal System; Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Inflammation of the uveal tract in which inflammation affects the anterior chamber, vitreous, retina or choroid.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012121","HPO_Name__c":"Panuveitis","Feature_System__c":"Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Blockage of a branch of the retinal artery. This can cause loss of a section of visual field.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0020161","HPO_Name__c":"Branch retinal artery occlusion","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"An inflammation of the endocardium, the inner layer of the heart, which usually involves the heart valves.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100584","HPO_Name__c":"Endocarditis","Feature_System__c":"Cardiovascular System; Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Separation of the inner layers of the retina (neural retina) from the pigment epithelium.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000541","HPO_Synonym__c":"Detached retina; Retinal detachment","HPO_Name__c":"Retinal detachment","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002027","HPO_Synonym__c":"Abdominal pain; Pain in stomach; Stomach pain","HPO_Name__c":"Abdominal pain","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Joint pain.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002829","HPO_Synonym__c":"Arthralgias; Joint pain","HPO_Name__c":"Arthralgia","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Enlargement (swelling) of a lymph node.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002716","HPO_Synonym__c":"Lymph node hyperplasia; Swollen lymph nodes","HPO_Name__c":"Lymphadenopathy","Feature_System__c":"Cardiovascular System; Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"A circumscribed, solid elevation of skin with no visible fluid that is reddish (erythematous) in color.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0030350","HPO_Name__c":"Erythematous papule","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Inflammation of the retina of the eye.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0032118","HPO_Name__c":"Retinitis","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An increased erythrocyte sedimentation rate (ESR). The ESR is a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0003565","HPO_Synonym__c":"Elevated ESR; Elevated sedimentation rate; High erythrocyte sedimentation rate; High ESR; Increased erythrocyte sedimentation rate; Raised erythrocyte sedimentation rate","HPO_Name__c":"Elevated erythrocyte sedimentation rate","HPO_Feature_Type__c":"Lab"}},{"Provided_By__c":"ORPHA:50839","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Simultaneous enlargement of the liver and spleen.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001433","HPO_Synonym__c":"Enlarged liver and spleen","HPO_Name__c":"Hepatosplenomegaly","Feature_System__c":"Cardiovascular System; Immune System; Digestive System","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Disease Category":["Infectious Disease"],"Specialist":["Infectious Disease","Pediatrics"],"Cause":["Rare Bacterial Infectious Disease"]},"synonyms":["bartonellosis due to bartonella henselae infection"," benign inoculation lymphoreticulosis"," benign lymphoreticulosis"," cat scratch fever"," cat-scratch disease"," cat-scratch fever"," csd - cat scratch disease"," debre-mollaret syndrome"," debre's syndrome"," foshay-mollaret cat scratch fever"]}