{"Name":"Generalized resistance to thyroid hormone","DiseaseID__c":"GARD:0000301","id":301,"encodedName":"generalized-resistance-to-thyroid-hormone","IsDeleted":false,"Disease_Name_Full__c":"Generalized resistance to thyroid hormone","Xref_IDs__c":"C131816; C4722330; MEDGEN:1654700; MONDO:0009043","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":1,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0009043","Disease_Description__c":"A thyroid hormone resistance syndrome characterized by resistance in the pituitary gland and in most or all of the peripheral tissues.","GARD_Name__c":"Generalized resistance to thyroid hormone","GARD_Synonym__c":"elevated serum levels of free thyroid hormone with nonsuppressed tsh; end-organ unresponsiveness to thyroid hormone; general resistance to thyrotropin; grth; impaired sensitivity to thyroid hormone; refetoff syndrome; resistance to thyroid hormone; syndrome of reduced sensitivity to thyroid hormone; thyroid hormone receptor beta; thyroid hormone receptor defect","Curated_Disease_Description_Source__c":"MONDO:0009043","Curated_Disease_Description__c":"A thyroid hormone resistance syndrome characterized by resistance in the pituitary gland and in most or all of the peripheral tissues.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0009043","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A thyroid hormone resistance syndrome characterized by resistance in the pituitary gland and in most or all of the peripheral tissues.","Curated_Disease_Description_Source__c":"MONDO:0009043","GARD_Synonym__c":"elevated serum levels of free thyroid hormone with nonsuppressed tsh; end-organ unresponsiveness to thyroid hormone; general resistance to thyrotropin; grth; impaired sensitivity to thyroid hormone; refetoff syndrome; resistance to thyroid hormone; syndrome of reduced sensitivity to thyroid hormone; thyroid hormone receptor beta; thyroid hormone receptor defect","Name":"Generalized resistance to thyroid hormone","estimateUsa":""}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=1654700","Source__c":"C4722330","Xref__c":"MEDGEN:1654700"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C4722330","Source__c":"C4722330","Xref__c":"C4722330"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0002930","Source__c":"C4722330","Xref__c":"HP:0002930"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0009043","Source__c":"GARD:0000301","Xref__c":"MONDO:0009043"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=237560005","Source__c":"C4722330","Xref__c":"237560005"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C131816","Source__c":"C4722330","Xref__c":"C131816"}],"tags":{},"synonyms":["elevated serum levels of free thyroid hormone with nonsuppressed tsh"," end-organ unresponsiveness to thyroid hormone"," general resistance to thyrotropin"," grth"," impaired sensitivity to thyroid hormone"," refetoff syndrome"," resistance to thyroid hormone"," syndrome of reduced sensitivity to thyroid hormone"," thyroid hormone receptor beta"," thyroid hormone receptor defect"]}