{"Name":"Anaplastic large cell lymphoma","DiseaseID__c":"GARD:0003112","id":3112,"encodedName":"anaplastic-large-cell-lymphoma","IsDeleted":false,"Disease_Name_Full__c":"Anaplastic large cell lymphoma","Xref_IDs__c":"277637000; C0206180; C3720; D017728; DOID:0050744; MEDGEN:61533; MONDO:0020325; ORPHA:98841","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0020325","Disease_Description__c":"A rare and aggressive peripheral T-cell non-Hodgkin lymphoma, belonging to the group of CD30-positive lymphoproliferative disorders, which affects lymph nodes and extranodal sites. It is comprised of two sub-types, based on the expression of a protein called anaplastic lymphoma kinase (ALK): ALK positive and ALK negative ALCL.","GARD_Name__c":"Anaplastic large cell lymphoma","GARD_Synonym__c":"alcl; anaplastic large cell lymphoma (alcl) cd30+; anaplastic large cell lymphoma cd30 positive; anaplastic large cell lymphoma, cd30+; anaplastic large cell lymphoma, t cell and null cell type; anaplastic large-cell lymphoma; cd30 positive anaplastic large cell lymphoma; ki-1 lymphoma; ki-1 positive anaplastic large cell lymphoma; ki-1+ alcl; ki-1+ anaplastic large cell lymphoma; large cell (ki-1 positive) lymphoma; large cell anaplastic lymphoma t cell and null cell type; primary systemic alcl; sacl","Curated_Disease_Description_Source__c":"GARD:0003112","Curated_Disease_Description__c":"Anaplastic large cell lymphoma (ALCL) is a rare type of Non-Hodgkins lymphoma. Lymphoma is a cancer of the lymph system, part of our immune system. Non-Hodgkins lymphoma involves abnormal growth of white blood cells, either T cells or B cells. Anaplastic large cell lymphoma is an aggressive cancer that usually involves the T-cells. Cancer cells in ALCL can be identified by their appearance under the microscope and by the presence of a tumor marker called CD30 or Ki-1. There are two types of ALCL, a type that affects mainly the skin (cutaneous ALCL) and a type that affects other body organs (systmic ALCL). Systemic ALCL also has two types, ALK-positive (anaplastic lymphoma kinase) and ALK-negative. ALK-positive ALCL occurs more often in children and young adults. ALK-negative ALCL tends to occur in older adults. The symptoms of cutaneous ALCL include red skin lesions that break open and do not heal. Sometimes cutaneous ALCL is also found in the lymph nodes. The symptoms of systemic ALCL include fever, night sweats, and weight loss (B symptoms). The cancer can be found in the bone, soft tissue, spleen, liver and skin. The cause of ALCL is unknown. One type of ALK-negative ALCL has been associated with breast implants. ALCL is diagnosed by a biopsy of the tumor or abnormal skin and examination of the tumor cells under a microscope. Additional testing including PET scans, CT scans, MRI and a bone marrow biopsy can tell doctors if the cancer has spread to other organs.[15060","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:98841","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0020325","ORPHANET_ID__c":"ORPHA:98841","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Linfoma anaplásico de células grandes","Spanish_Description_Source__c":"ORPHA:98841","Spanish_Description__c":"Es un linfoma periférico no-Hodgkin de células T poco frecuente y agresivo, perteneciente al grupo de los trastornos linfoproliferativos CD30 positivo, que afecta a los ganglios linfáticos y regiones extraganglionares. Según la expresión de una proteína denominada quinasa del linfoma anaplásico (ALK) se clasifica en dos grupos: ALK positivo y ALK negativo.","Spanish_Disease_Name__c":"linfoma anaplásico de células grandes","Spanish_GARD_Synonym__c":"alcl; alcl sistémico primario; linfoma anaplásico de células grandes cd30 positivo; linfoma anaplásico de células grandes ki-1 positivo; sacl","Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Anaplastic large cell lymphoma (ALCL) is a rare type of Non-Hodgkins lymphoma. Lymphoma is a cancer of the lymph system, part of our immune system. Non-Hodgkins lymphoma involves abnormal growth of white blood cells, either T cells or B cells. Anaplastic large cell lymphoma is an aggressive cancer that usually involves the T-cells. Cancer cells in ALCL can be identified by their appearance under the microscope and by the presence of a tumor marker called CD30 or Ki-1. There are two types of ALCL, a type that affects mainly the skin (cutaneous ALCL) and a type that affects other body organs (systmic ALCL). Systemic ALCL also has two types, ALK-positive (anaplastic lymphoma kinase) and ALK-negative. ALK-positive ALCL occurs more often in children and young adults. ALK-negative ALCL tends to occur in older adults. The symptoms of cutaneous ALCL include red skin lesions that break open and do not heal. Sometimes cutaneous ALCL is also found in the lymph nodes. The symptoms of systemic ALCL include fever, night sweats, and weight loss (B symptoms). The cancer can be found in the bone, soft tissue, spleen, liver and skin. The cause of ALCL is unknown. One type of ALK-negative ALCL has been associated with breast implants. ALCL is diagnosed by a biopsy of the tumor or abnormal skin and examination of the tumor cells under a microscope. Additional testing including PET scans, CT scans, MRI and a bone marrow biopsy can tell doctors if the cancer has spread to other organs.[15060","Curated_Disease_Description_Source__c":"GARD:0003112","GARD_Synonym__c":"alcl; anaplastic large cell lymphoma (alcl) cd30+; anaplastic large cell lymphoma cd30 positive; anaplastic large cell lymphoma, cd30+; anaplastic large cell lymphoma, t cell and null cell type; anaplastic large-cell lymphoma; cd30 positive anaplastic large cell lymphoma; ki-1 lymphoma; ki-1 positive anaplastic large cell lymphoma; ki-1+ alcl; ki-1+ anaplastic large cell lymphoma; large cell (ki-1 positive) lymphoma; large cell anaplastic lymphoma t cell and null cell type; primary systemic alcl; sacl","Name":"Anaplastic large cell lymphoma","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"HealthTree Foundation","Website__c":"https://healthtree.org/"},{"Account_Name__c":"Lymphoma Research Foundation","Website__c":"https://lymphoma.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Hematology","Tag_Category__c":"Disease Category;Specialist","category_description":"Blood diseases affect the blood or blood-forming organs, including red blood cells, white blood cells, platelets, plasma, and bone marrow.","curated_tag_name":"Blood diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:98841"}],"Diagnosis__c":[{"Type__c":"GTR","Curie__c":"MEDGEN:C0206180"}],"External_Identifier_Disease__c":[{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3720","Source__c":"C0206180; MONDO:0020325","Xref__c":"C3720"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=277637000","Source__c":"MONDO:0020325","Xref__c":"277637000"},{"URL__c":"https://www.orpha.net/en/disease/detail/98841","Source__c":"MONDO:0020325","Xref__c":"ORPHA:98841"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0050744","Source__c":"MONDO:0020325","Xref__c":"DOID:0050744"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C017728","Source__c":"C0206180; MONDO:0020325","Xref__c":"D017728"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=61533","Source__c":"C0206180","Xref__c":"MEDGEN:61533"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0206180","Source__c":"C0206180","Xref__c":"C0206180"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=702785000","Source__c":"C0206180","Xref__c":"702785000"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=53237008","Source__c":"C0206180","Xref__c":"53237008"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0012193","Source__c":"C0206180","Xref__c":"HP:0012193"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0020325","Source__c":"GARD:0003112","Xref__c":"MONDO:0020325"}],"tags":{"Specialist":["Cancer - Oncologist","Hematology","Pediatrics"],"Disease Category":["Cancer","Hematology"]},"synonyms":["alcl"," anaplastic large cell lymphoma (alcl) cd30+"," anaplastic large cell lymphoma cd30 positive"," anaplastic large cell lymphoma, cd30+"," anaplastic large cell lymphoma, t cell and null cell type"," anaplastic large-cell lymphoma"," cd30 positive anaplastic large cell lymphoma"," ki-1 lymphoma"," ki-1 positive anaplastic large cell lymphoma"," ki-1+ alcl"," ki-1+ anaplastic large cell lymphoma"," large cell (ki-1 positive) lymphoma"," large cell anaplastic lymphoma t cell and null cell type"," primary systemic alcl"," sacl"]}