{"Name":"Klumpke-Déjerine paralysis","DiseaseID__c":"GARD:0003123","id":3123,"encodedName":"klumpke-djerine-paralysis","IsDeleted":false,"Disease_Name_Full__c":"Klumpke-Déjerine paralysis","Xref_IDs__c":"83886009; C0270898; C116724; MEDGEN:124376; MONDO:0023054","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0023054","Disease_Description__c":"Klumpke paralysis is a type of brachial palsy in newborns. Signs and symptoms include weakness and loss of movement of the arm and hand. Some babies experience drooping of the eyelid on the opposite side of the face as well. This symptom may also be referred to as Horner syndrome. Klumpke paralysis is caused by an injury to the nerves of the brachial plexus which may result from a difficult delivery. This injury can cause a stretching (neuropraxia), tearing (called avulsion when the tear is at the spine, and rupture when it is not), or scarring (neuroma) of the brachial plexus nerves. Most infants with Klumpke paralysis have the more mild form of injury (neuropraxia) and often recover within 6 months.","GARD_Name__c":"Klumpke-Déjerine paralysis","GARD_Synonym__c":"dejerine-klumpke palsy; klumpke paralysis; klumpke-dejerine paralysis; klumpke-déjerine brachial plexus injury; klumpke's palsy; klumpke's paralysis; lower brachial plexus palsy","Curated_Disease_Description_Source__c":"GARD:0003123","Curated_Disease_Description__c":"Klumpke paralysis is a rare type of birth injury to the nerves around a newborn's shoulder, known as the brachial plexus. Most types of brachial plexus injuries affect the shoulder and upper arm. Klumpke paralysis affects the movement of the lower arm and hand. Signs and symptoms include weakness and loss of movement of the lower arm and hand. Some babies experience drooping of the eyelid on the opposite side of the face as well. This symptom may also be referred to as Horner syndrome. Klumpke paralysis is caused by an injury to the nerves of the brachial plexus which may result during birth due to a difficult delivery. This injury can cause a stretch injury (neuropraxia), scarring, or tearing of the brachial plexus nerves. Tearing is called an 'avulsion' when the tear is at the spine, and 'rupture' when it is not. Diagnosis of Klumpke paralysis is made at birth by physical examination. Sometimes x-rays and other tests are done to determine the extent of the nerve damage. Most infants with Klumpke paralysis have the milder form of injury (neuropraxia) and often recover within 6 months. Some infants will require surgery. Rarely, infants with Klumpke paralysis will have some permanent damage.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0023054","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Klumpke paralysis is a rare type of birth injury to the nerves around a newborn's shoulder, known as the brachial plexus. Most types of brachial plexus injuries affect the shoulder and upper arm. Klumpke paralysis affects the movement of the lower arm and hand. Signs and symptoms include weakness and loss of movement of the lower arm and hand. Some babies experience drooping of the eyelid on the opposite side of the face as well. This symptom may also be referred to as Horner syndrome. Klumpke paralysis is caused by an injury to the nerves of the brachial plexus which may result during birth due to a difficult delivery. This injury can cause a stretch injury (neuropraxia), scarring, or tearing of the brachial plexus nerves. Tearing is called an 'avulsion' when the tear is at the spine, and 'rupture' when it is not. Diagnosis of Klumpke paralysis is made at birth by physical examination. Sometimes x-rays and other tests are done to determine the extent of the nerve damage. Most infants with Klumpke paralysis have the milder form of injury (neuropraxia) and often recover within 6 months. Some infants will require surgery. Rarely, infants with Klumpke paralysis will have some permanent damage.","Curated_Disease_Description_Source__c":"GARD:0003123","GARD_Synonym__c":"dejerine-klumpke palsy; klumpke paralysis; klumpke-dejerine paralysis; klumpke-déjerine brachial plexus injury; klumpke's palsy; klumpke's paralysis; lower brachial plexus palsy","Name":"Klumpke-Déjerine paralysis","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"United Brachial Plexus Network","Website__c":"https://ubpn.org/"},{"Account_Name__c":"Periodic Paralysis Association","Website__c":"https://periodicparalysis.org/"},{"Account_Name__c":"Periodic Paralysis International","Website__c":"https://www.hkpp.org/"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0270898","Source__c":"C0270898","Xref__c":"C0270898"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=83886009","Source__c":"C0270898; MONDO:0023054","Xref__c":"83886009"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C116724","Source__c":"C0270898; MONDO:0023054","Xref__c":"C116724"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=124376","Source__c":"C0270898","Xref__c":"MEDGEN:124376"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0023054","Source__c":"GARD:0003123","Xref__c":"MONDO:0023054"}],"tags":{},"synonyms":["dejerine-klumpke palsy"," klumpke paralysis"," klumpke-dejerine paralysis"," klumpke-déjerine brachial plexus injury"," klumpke's palsy"," klumpke's paralysis"," lower brachial plexus palsy"]}