{"Name":"Malignant lymphoma, large B-cell, diffuse","DiseaseID__c":"GARD:0003178","id":3178,"encodedName":"malignant-lymphoma-large-b-cell-diffuse","IsDeleted":false,"Disease_Name_Full__c":"Malignant lymphoma, large B-cell, diffuse","Xref_IDs__c":"C0079744; C83.3; C8851; D016403; DOID:0050745; MEDGEN:86954; MONDO:0018905; ORPHA:544","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0018905","Disease_Description__c":"Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL; see this term) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common.","GARD_Name__c":"Malignant lymphoma, large B-cell, diffuse","GARD_Synonym__c":"centroblastic diffuse large b-cell malignant lymphoma; centroblastic diffuse malignant lymphoma; centroblastic malignant lymphoma; diffuse large b cell lymphoma; diffuse large b cell malignant lymphoma; diffuse large b-cell lymphoma; diffuse large b-cell malignant lymphoma; diffuse large cleaved cell malignant lymphoma; diffuse large noncleaved cell malignant lymphoma; diffuse malignant lymphoma - histiocytic; diffuse malignant lymphoma - large cell; diffuse non-hodgkin lymphoma, large cell; diffuse non-hodgkin's lymphoma, large cell; dlbcl; dlbcl - diffuse large b cell lymphoma; histiocytic diffuse malignant lymphoma; histiocytic malignant lymphoma; large b-cell malignant lymphoma; large cell malignant lymphoma; large cleaved cell and noncleaved cell malignant lymphoma; large cleaved cell malignant lymphoma; large noncleaved cell malignant lymphoma; lymphoma, diffuse large b cell, non hodgkins; malignant lymphoma - large cell cleaved and non-cleaved; noncleaved malignant lymphoma","Curated_Disease_Description_Source__c":"GARD:0003178","Curated_Disease_Description__c":"Diffuse Large B-Cell Lymphoma (DLBCL), a form of non-Hodgkin lymphoma, is the most common blood cancer. Lymphomas occur when cells of the immune system, known as B lymphocytes, grow and multiply uncontrollably. DLBCL occurs mostly in adults and is a fast-growing (aggressive) lymphoma. It can start in the lymph nodes or outside of the lymphatic system in the gastrointestinal tract, testes, thyroid, skin, breast, bone, or brain. Often, the first sign of DLBCL is a painless rapid swelling in the neck, armpit, abdomen, or groin caused by enlarged lymph nodes. For some people, the swelling may be painful. Other symptoms include night sweats, unexplained fevers, and weight loss.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:544","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0018905","ORPHANET_ID__c":"ORPHA:544","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Linfoma difuso de células b grandes","Spanish_Description_Source__c":"ORPHA:544","Spanish_Description__c":"Es el subtipo más común de linfoma no Hodgkin (LNH) en adultos y se caracteriza por una mediana de edad de presentación en la sexta década de la vida (pero también ocurre con baja frecuencia en adolescentes y niños) con una presentación inicial de una o varias masas de rápido crecimiento (que pueden o no ser dolorosas) en sitios ganglionares o extraganglionares (como tiroides, piel, mama, tracto digestivo, testículos, hueso o cerebro) y que pueden acompañarse de síntomas como fiebre, sudores nocturnos y pérdida de peso. El LDCGB tiene un curso de enfermedad agresivo. Los adultos de edad avanzada presentan un peor pronóstico que los pacientes más jóvenes, y las recaídas son comunes.","Spanish_Disease_Name__c":"linfoma difuso de células b grandes","Spanish_GARD_Synonym__c":"dlbcl; ldcbg","Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Diffuse Large B-Cell Lymphoma (DLBCL), a form of non-Hodgkin lymphoma, is the most common blood cancer. Lymphomas occur when cells of the immune system, known as B lymphocytes, grow and multiply uncontrollably. DLBCL occurs mostly in adults and is a fast-growing (aggressive) lymphoma. It can start in the lymph nodes or outside of the lymphatic system in the gastrointestinal tract, testes, thyroid, skin, breast, bone, or brain. Often, the first sign of DLBCL is a painless rapid swelling in the neck, armpit, abdomen, or groin caused by enlarged lymph nodes. For some people, the swelling may be painful. Other symptoms include night sweats, unexplained fevers, and weight loss.","Curated_Disease_Description_Source__c":"GARD:0003178","GARD_Synonym__c":"centroblastic diffuse large b-cell malignant lymphoma; centroblastic diffuse malignant lymphoma; centroblastic malignant lymphoma; diffuse large b cell lymphoma; diffuse large b cell malignant lymphoma; diffuse large b-cell lymphoma; diffuse large b-cell malignant lymphoma; diffuse large cleaved cell malignant lymphoma; diffuse large noncleaved cell malignant lymphoma; diffuse malignant lymphoma - histiocytic; diffuse malignant lymphoma - large cell; diffuse non-hodgkin lymphoma, large cell; diffuse non-hodgkin's lymphoma, large cell; dlbcl; dlbcl - diffuse large b cell lymphoma; histiocytic diffuse malignant lymphoma; histiocytic malignant lymphoma; large b-cell malignant lymphoma; large cell malignant lymphoma; large cleaved cell and noncleaved cell malignant lymphoma; large cleaved cell malignant lymphoma; large noncleaved cell malignant lymphoma; lymphoma, diffuse large b cell, non hodgkins; malignant lymphoma - large cell cleaved and non-cleaved; noncleaved malignant lymphoma","Name":"Malignant lymphoma, large B-cell, diffuse","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Lymphoma Research Foundation","Website__c":"https://lymphoma.org/"},{"Account_Name__c":"HealthTree Foundation","Website__c":"https://healthtree.org/"},{"Account_Name__c":"Lymphoma Coalition","Website__c":"https://lymphomacoalition.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Hematology","Tag_Category__c":"Disease Category;Specialist","category_description":"Blood diseases affect the blood or blood-forming organs, including red blood cells, white blood cells, platelets, plasma, and bone marrow.","curated_tag_name":"Blood diseases"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:544"}],"Diagnosis__c":[{"Type__c":"GTR","Curie__c":"MEDGEN:C0079744"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0050745","Source__c":"MONDO:0018905","Xref__c":"DOID:0050745"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=86954","Source__c":"C0079744","Xref__c":"MEDGEN:86954"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C016403","Source__c":"C0079744; MONDO:0018905","Xref__c":"D016403"},{"URL__c":"https://www.orpha.net/en/disease/detail/544","Source__c":"C0079744; MONDO:0018905; ORPHA:544","Xref__c":"ORPHA:544"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0079744","Source__c":"C0079744","Xref__c":"C0079744"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C8851","Source__c":"C0079744; MONDO:0018905","Xref__c":"C8851"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=1172695008","Source__c":"C0079744","Xref__c":"1172695008"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/C83.3","Source__c":"MONDO:0018905","Xref__c":"C83.3"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=109969005","Source__c":"C0079744","Xref__c":"109969005"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0018905","Source__c":"GARD:0003178","Xref__c":"MONDO:0018905"}],"Inheritance__c":["Non-Mendelian inheritance"],"tags":{"Specialist":["Cancer - Oncologist","Hematology"],"Disease Category":["Cancer","Hematology"]},"synonyms":["centroblastic diffuse large b-cell malignant lymphoma"," centroblastic diffuse malignant lymphoma"," centroblastic malignant lymphoma"," diffuse large b cell lymphoma"," diffuse large b cell malignant lymphoma"," diffuse large b-cell lymphoma"," diffuse large b-cell malignant lymphoma"," diffuse large cleaved cell malignant lymphoma"," diffuse large noncleaved cell malignant lymphoma"," diffuse malignant lymphoma - histiocytic"," diffuse malignant lymphoma - large cell"," diffuse non-hodgkin lymphoma, large cell"," diffuse non-hodgkin's lymphoma, large cell"," dlbcl"," dlbcl - diffuse large b cell lymphoma"," histiocytic diffuse malignant lymphoma"," histiocytic malignant lymphoma"," large b-cell malignant lymphoma"," large cell malignant lymphoma"," large cleaved cell and noncleaved cell malignant lymphoma"," large cleaved cell malignant lymphoma"," large noncleaved cell malignant lymphoma"," lymphoma, diffuse large b cell, non hodgkins"," malignant lymphoma - large cell cleaved and non-cleaved"," noncleaved malignant lymphoma"]}