{"Name":"Graham Little-Piccardi-Lassueur syndrome","DiseaseID__c":"GARD:0003195","id":3195,"encodedName":"graham-little-piccardi-lassueur-syndrome","IsDeleted":false,"Disease_Name_Full__c":"Graham Little-Piccardi-Lassueur syndrome","Xref_IDs__c":"718215008; C4273658; MEDGEN:905915; MONDO:0018858; ORPHA:505","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":1,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":6,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0018858","Disease_Description__c":"A variant of lichen planopilaris characterized by the clinical triad of progressive cicatricial (scarring) alopecia of the scalp, follicular keratotic papules on glabrous skin, and variable alopecia of the axillae and groin.","GARD_Name__c":"Graham Little-Piccardi-Lassueur syndrome","GARD_Synonym__c":"graham little piccardi lassueur syndrome; graham little syndrome; picardi-lassueur-little syndrome; piccardi lassueur little syndrome; piccardi-lassueur-little syndrome","Curated_Disease_Description_Source__c":"GARD:0003195","Curated_Disease_Description__c":"Graham-Little-Piccardi-Lassueur syndrome (GLPLS) is a rare type of scarring hair loss. It is most commonly found in otherwise healthy adult woman. GLPLS is characterized by three features: progressive patchy scarring hair loss of the scalp (cicatricial alopecia), non-scarring thinning of the hair in the armpits and groin (noncicatricial alopecia), and spiky rough bumps based around hair follicles (follicular lichen planus). Sometimes individuals with GLPLS experience itching around affected areas, which can be severe.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:505","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0018858","ORPHANET_ID__c":"ORPHA:505","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Síndrome de graham little-piccardi-lassueur","Spanish_Description_Source__c":"ORPHA:505","Spanish_Description__c":"Es una variante del liquen plano pilar caracterizado por una triada clínica de alopecia cicatricial progresiva del cuero cabelludo, pápulas queratósicas foliculares en la piel lampiña, y alopecia variable en axilas e ingles.","Spanish_Disease_Name__c":"síndrome de graham little-piccardi-lassueur","Spanish_GARD_Synonym__c":"síndrome de graham little; síndrome de piccardi-lassueur-little","Category_Linearization__c":"ORPHA:89826","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Graham-Little-Piccardi-Lassueur syndrome (GLPLS) is a rare type of scarring hair loss. It is most commonly found in otherwise healthy adult woman. GLPLS is characterized by three features: progressive patchy scarring hair loss of the scalp (cicatricial alopecia), non-scarring thinning of the hair in the armpits and groin (noncicatricial alopecia), and spiky rough bumps based around hair follicles (follicular lichen planus). Sometimes individuals with GLPLS experience itching around affected areas, which can be severe.","Curated_Disease_Description_Source__c":"GARD:0003195","GARD_Synonym__c":"graham little piccardi lassueur syndrome; graham little syndrome; picardi-lassueur-little syndrome; piccardi lassueur little syndrome; piccardi-lassueur-little syndrome","Name":"Graham Little-Piccardi-Lassueur syndrome","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Scarring Alopecia Foundation","Website__c":"https://scarringalopecia.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Dermatology","Tag_Category__c":"Account;Disease Category;Specialist","category_description":"Skin diseases, or integumentary system diseases, affect the skin, hair, nails, sweat glands, or oil glands.","curated_tag_name":"Skin diseases"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:505"}],"External_Identifier_Disease__c":[{"URL__c":"https://raresource.nih.gov/diseases/filter/0003195","Source__c":"RareSource"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=718215008","Source__c":"C4273658; MONDO:0018858","Xref__c":"718215008"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=905915","Source__c":"C4273658","Xref__c":"MEDGEN:905915"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C4273658","Source__c":"C4273658","Xref__c":"C4273658"},{"URL__c":"https://www.orpha.net/en/disease/detail/505","Source__c":"C4273658; MONDO:0018858; ORPHA:505","Xref__c":"ORPHA:505"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0018858","Source__c":"GARD:0003195","Xref__c":"MONDO:0018858"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:505","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000989","HPO_Synonym__c":"Itching; Itchy skin; Skin itching","HPO_Name__c":"Pruritus","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:505","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Increased amount of keratin (visible as white scales) surrounding hair follicles.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0007468","HPO_Name__c":"Perifollicular hyperkeratosis","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:505","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Reduced number or density of axillary hair.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002215","HPO_Synonym__c":"Limited armpit hair; Little underarm hair; sparse to absent axillary hair","HPO_Name__c":"Sparse axillary hair","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:505","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Reduced number or density of pubic hair.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002225","HPO_Synonym__c":"Decreased sexual hair; Sparse pubic hair; sparse to absent pubic hair","HPO_Name__c":"Sparse pubic hair","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:505","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Decreased number of hairs per unit area of skin of the scalp.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002209","HPO_Synonym__c":"Decreased number of scalp follicles; Hypotrichosis on scalp; Reduced amount of scalp hair; Reduced/lack of hair on scalp; Reduction in the number of scalp follicles; Scalp hypotrichosis; Sparse scalp hair; Thinning scalp hair","HPO_Name__c":"Sparse scalp hair","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:505","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"A noncongenital process of hair loss, which may progress to partial or complete baldness.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001596","HPO_Synonym__c":"Hair loss","HPO_Name__c":"Alopecia","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:505","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Thickening and hardening of the epidermis seen with exaggeration of normal skin lines.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100725","HPO_Name__c":"Lichenification","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Account":["Dermatology"],"Disease Category":["Dermatology"],"Specialist":["Dermatology"]},"synonyms":["graham little piccardi lassueur syndrome"," graham little syndrome"," picardi-lassueur-little syndrome"," piccardi lassueur little syndrome"," piccardi-lassueur-little syndrome"]}