{"Name":"Twin-to-twin transfusion","DiseaseID__c":"GARD:0000325","id":325,"encodedName":"twin-to-twin-transfusion","IsDeleted":false,"Disease_Name_Full__c":"Twin-to-twin transfusion","Xref_IDs__c":"13404009; C113824; C2909036; D005330; DOID:13576; HP:0031110; MEDGEN:777055; MONDO:0019805; ORPHA:95431","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":3,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0019805","Disease_Description__c":"Twin twin transfusion syndrome (TTTS) is a rare condition seen in twin monochorionic pregnancies, typically developing during the 15-26 week gestation period and usually due to unbalanced intertwin placental anastomoses, where an unequal exchange of blood between twins causes oligohydramnios in one sac and polyhydramnios in the other which can lead to a high perinatal mortality rate and a high rate of disability in survivors if left untreated","GARD_Name__c":"Twin-to-twin transfusion","GARD_Synonym__c":"fetal blood loss from fetal hemorrhage into co-twin; fetal hemorrhage into co-twin; fetal transfusion syndrome; feto-fetal transfusion syndrome; fetofetal transfusion; fetofetal transfusion syndrome; ffts - fetofetal transfusion syndrome; foetal blood loss from foetal haemorrhage into co-twin; foetal haemorrhage into co-twin; placental transfusion syndrome; stuck twin syndrome; ttts - twin to twin transfusion syndrome; twin anemia polycythemia sequence; twin to twin transfusion; twin to twin transfusion syndrome; twin twin transfusion syndrome; twin-to-twin blood transfer; twin-to-twin transfusion syndrome; twin-twin transfusion syndrome","Curated_Disease_Description_Source__c":"GARD:0000325","Curated_Disease_Description__c":"Twin to twin transfusion syndrome (TTTS) is a rare condition that occurs during a twin pregnancy when blood moves from one twin (the 'donor twin') to the other (the 'recipient twin') while in the womb. TTTS is a complication that specifically occurs in identical (monozygotic) twin pregnancies that share the same \"egg\" sac (monochorionic) that may or may not share the same amniotic sac (monoamniotic). The donor twin may be born smaller, with paleness, anemia, and dehydration. The recipient twin may be born larger, with redness, too much blood, and increased blood pressure, resulting in an increased risk for heart failure.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":"ORPHA:95431","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0019805","ORPHANET_ID__c":"ORPHA:95431","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Síndrome de transfusión gemelo-gemelo","Spanish_Description_Source__c":"ORPHA:95431","Spanish_Description__c":"El síndrome de transfusión gemelo-gemelo (TTTS) es una enfermedad poco frecuente observada en embarazos monocoriales, que se desarrolla típicamente en las semanas 15-26 del periodo de gestación, y que es causada generalmente por el desequilibrio en la anastomosis placentaria entre gemelos, donde un intercambio de sangre desigual entre gemelos causa oligohidramnios en un saco y polihidramnios en el otro, lo que puede dar lugar a una alta tasa de mortalidad perinatal y una alta tasa de discapacidad en los supervivientes si no es tratado.","Spanish_Disease_Name__c":"síndrome de transfusión gemelo-gemelo","Spanish_GARD_Synonym__c":"síndrome de transfusión feto-fetal","Category_Linearization__c":"ORPHA:96344","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Twin to twin transfusion syndrome (TTTS) is a rare condition that occurs during a twin pregnancy when blood moves from one twin (the 'donor twin') to the other (the 'recipient twin') while in the womb. TTTS is a complication that specifically occurs in identical (monozygotic) twin pregnancies that share the same \"egg\" sac (monochorionic) that may or may not share the same amniotic sac (monoamniotic). The donor twin may be born smaller, with paleness, anemia, and dehydration. The recipient twin may be born larger, with redness, too much blood, and increased blood pressure, resulting in an increased risk for heart failure.","Curated_Disease_Description_Source__c":"GARD:0000325","GARD_Synonym__c":"fetal blood loss from fetal hemorrhage into co-twin; fetal hemorrhage into co-twin; fetal transfusion syndrome; feto-fetal transfusion syndrome; fetofetal transfusion; fetofetal transfusion syndrome; ffts - fetofetal transfusion syndrome; foetal blood loss from foetal haemorrhage into co-twin; foetal haemorrhage into co-twin; placental transfusion syndrome; stuck twin syndrome; ttts - twin to twin transfusion syndrome; twin anemia polycythemia sequence; twin to twin transfusion; twin to twin transfusion syndrome; twin twin transfusion syndrome; twin-to-twin blood transfer; twin-to-twin transfusion syndrome; twin-twin transfusion syndrome","Name":"Twin-to-twin transfusion","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"The Twin to Twin Transfusion Syndrome Foundation","Website__c":"https://tttsfoundation.org/"},{"Account_Name__c":"Fetal Health Foundation","Website__c":"https://www.fetalhealthfoundation.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Immunology","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Urogenital Disorders","Tag_Category__c":"Disease Category","category_description":"Urinary and reproductive diseases affect the kidneys, ureters, bladder, urethra, or the reproductive organs.","curated_tag_name":"Urinary and reproductive diseases"},{"Tag_Name__c":"Obstetrics / Gynecology","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Pregnancy-Related Diseases","Tag_Category__c":"Specialist","curated_tag_name":"Pregnancy-related diseases"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=777055","Source__c":"C2909036","Xref__c":"MEDGEN:777055"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A13576","Source__c":"MONDO:0019805","Xref__c":"DOID:13576"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C005330","Source__c":"C2909036; MONDO:0019805","Xref__c":"D005330"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C2909036","Source__c":"C2909036","Xref__c":"C2909036"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C113824","Source__c":"C2909036; MONDO:0019805","Xref__c":"C113824"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=13404009","Source__c":"C2909036; MONDO:0019805","Xref__c":"13404009"},{"URL__c":"https://www.orpha.net/en/disease/detail/95431","Source__c":"C2909036; MONDO:0019805; ORPHA:95431","Xref__c":"ORPHA:95431"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0019805","Source__c":"GARD:0000325","Xref__c":"MONDO:0019805"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0031110","Source__c":"C2909036","Xref__c":"HP:0031110"}],"tags":{"Specialist":["Immunology","Obstetrics / Gynecology","Pregnancy-Related Diseases"],"Disease Category":["Urogenital Disorders"]},"synonyms":["fetal blood loss from fetal hemorrhage into co-twin"," fetal hemorrhage into co-twin"," fetal transfusion syndrome"," feto-fetal transfusion syndrome"," fetofetal transfusion"," fetofetal transfusion syndrome"," ffts - fetofetal transfusion syndrome"," foetal blood loss from foetal haemorrhage into co-twin"," foetal haemorrhage into co-twin"," placental transfusion syndrome"," stuck twin syndrome"," ttts - twin to twin transfusion syndrome"," twin anemia polycythemia sequence"," twin to twin transfusion"," twin to twin transfusion syndrome"," twin twin transfusion syndrome"," twin-to-twin blood transfer"," twin-to-twin transfusion syndrome"," twin-twin transfusion syndrome"]}