{"Name":"Loiasis","DiseaseID__c":"GARD:0003283","id":3283,"encodedName":"loiasis","IsDeleted":false,"Disease_Name_Full__c":"Loiasis","Xref_IDs__c":"44250009; B74.3; C0023968; C34784; D008118; DOID:13523; MEDGEN:6132; MONDO:0016566; ORPHA:2404","USA_Estimate__c":"1,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"1 to 8,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0016566","Disease_Description__c":"Loiasis is a form of filariasis (see this term), caused by the parasitic worm <i>Loa loa</i>, endemic to the forest and savannah regions of Central and Western Africa. Loiasis may either be asymptomatic or manifest as a large, transient area of localized, non-erythematous subcutaneous edema (Calabar swellings), adult worm migration through the sub-conjunctiva (''African eye worm'') and pruritus. Generalized itching, hives, muscle pains, arthralgias, fatigue, and adult worms visibly migrating under the surface of the skin may be observed. Severe complications such as encephalopathy have been reported in highly infected individuals receiving ivermectin during mass drug administration programs for the control of onchocerciasis and lymphatic filariasis (see these terms).","GARD_Name__c":"Loiasis","GARD_Synonym__c":"eyeworm disease of africa; infection by loa loa; infection caused by loa loa; loa loa infection; loasis","Curated_Disease_Description_Source__c":"MONDO:0016566","Curated_Disease_Description__c":"Loiasis is a form of filariasis, caused by the parasitic worm Loa loa, endemic to the forest and savannah regions of Central and Western Africa. Loiasis may either be asymptomatic or manifest as a large, transient area of localized, non-erythematous subcutaneous edema (Calabar swellings), adult worm migration through the sub-conjunctiva ('African eye worm') and pruritus. Generalized itching, hives, muscle pains, arthralgias, fatigue, and adult worms visibly migrating under the surface of the skin may be observed. Severe complications such as encephalopathy have been reported in highly infected individuals receiving ivermectin during mass drug administration programs for the control of onchocerciasis and lymphatic filariasis.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"1,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:2404","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0016566","ORPHANET_ID__c":"ORPHA:2404","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Loasis","Spanish_Description_Source__c":"ORPHA:2404","Spanish_Description__c":"La loasis es una forma de filariasis (véase este término) causada por el gusano parásito <i>Loa loa</i>, endémico de las regiones selváticas y de la sabana del África central y occidental. La loasis puede ser asintomática o manifestarse como una zona de edema no eritematoso subcutáneo (edema de Calabar) extensa, transitoria y localizada, migración de los gusanos adultos a través de la subconjuntiva (\"gusano africano del ojo\") y prurito. Se puede observar picor generalizado, urticaria, dolores musculares, artralgias, fatiga y gusanos adultos migrando de manera visible bajo la superficie de la piel. En individuos con alto grado de infección que reciben ivermectina en programas de administración de fármacos en masa para el control de la oncocercosis y la filasiasis linfática (véanse estos términos) se han observado graves complicaciones tales como la encefalopatía.","Spanish_Disease_Name__c":"loasis","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:68416","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Loiasis is a form of filariasis, caused by the parasitic worm Loa loa, endemic to the forest and savannah regions of Central and Western Africa. Loiasis may either be asymptomatic or manifest as a large, transient area of localized, non-erythematous subcutaneous edema (Calabar swellings), adult worm migration through the sub-conjunctiva ('African eye worm') and pruritus. Generalized itching, hives, muscle pains, arthralgias, fatigue, and adult worms visibly migrating under the surface of the skin may be observed. Severe complications such as encephalopathy have been reported in highly infected individuals receiving ivermectin during mass drug administration programs for the control of onchocerciasis and lymphatic filariasis.","Curated_Disease_Description_Source__c":"MONDO:0016566","GARD_Synonym__c":"eyeworm disease of africa; infection by loa loa; infection caused by loa loa; loa loa infection; loasis","Name":"Loiasis","Curated_USA_Estimate__c":"1,000","estimateUsa":"1,000"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Infectious Disease","Tag_Category__c":"Disease Category;Specialist","category_description":"Infectious diseases are caused by bacteria, viruses, fungi, or parasites entering the body, multiplying, and spreading illness.","curated_tag_name":"Infectious diseases"},{"Tag_Name__c":"Rare Parasitic Disease","Tag_Category__c":"Cause","curated_tag_name":"Parasitic Infectious Diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:2404"}],"External_Identifier_Disease__c":[{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/B74.3","Source__c":"MONDO:0016566","Xref__c":"B74.3"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C34784","Source__c":"C0023968; MONDO:0016566","Xref__c":"C34784"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C008118","Source__c":"C0023968; MONDO:0016566","Xref__c":"D008118"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A13523","Source__c":"MONDO:0016566","Xref__c":"DOID:13523"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0023968","Source__c":"C0023968","Xref__c":"C0023968"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=6132","Source__c":"C0023968","Xref__c":"MEDGEN:6132"},{"URL__c":"https://www.orpha.net/en/disease/detail/2404","Source__c":"C0023968; MONDO:0016566; ORPHA:2404","Xref__c":"ORPHA:2404"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=44250009","Source__c":"C0023968; MONDO:0016566","Xref__c":"44250009"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0016566","Source__c":"GARD:0003283","Xref__c":"MONDO:0016566"}],"tags":{"Disease Category":["Infectious Disease"],"Specialist":["Infectious Disease","Pediatrics"],"Cause":["Rare Parasitic Disease"]},"synonyms":["eyeworm disease of africa"," infection by loa loa"," infection caused by loa loa"," loa loa infection"," loasis"]}