{"Name":"Loose anagen hair syndrome","DiseaseID__c":"GARD:0003287","id":3287,"encodedName":"loose-anagen-hair-syndrome","IsDeleted":false,"Disease_Name_Full__c":"Loose anagen hair syndrome","Xref_IDs__c":"238735005; C0406468; D058247; DOID:0111702; MEDGEN:98351; MONDO:0010908; OMIM:600628; ORPHA:168","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":1,"Disease_Characteristics_Score__c":7,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0010908","Disease_Description__c":"Loose anagen syndrome is a rare benign hair disorder affecting predominantly blond females in childhood and characterized by the presence of hair that can be easily and painlessly pulled out. Most of the hair is in the anagen phase and lacks an external epithelial sheath. Hair grows back quickly and the condition improves spontaneously with aging. Loose anagen hair can be associated with other anomalies, such as coloboma.","GARD_Name__c":"Loose anagen hair syndrome","GARD_Synonym__c":"loose anagen syndrome","Curated_Disease_Description_Source__c":"MONDO:0010908","Curated_Disease_Description__c":"Loose anagen syndrome is a rare benign hair disorder affecting predominantly blond females in childhood and characterized by the presence of hair that can be easily and painlessly pulled out. Most of the hair is in the anagen phase and lacks an external epithelial sheath. Hair grows back quickly and the condition improves spontaneously with aging. Loose anagen hair can be associated with other anomalies, such as coloboma.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"as a Child","SourceID__c":"ORPHA:168","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0010908","ORPHANET_ID__c":"ORPHA:168","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Síndrome del cabello anágeno suelto","Spanish_Description_Source__c":"ORPHA:168","Spanish_Description__c":"El síndrome del cabello anágeno suelto es una enfermedad rara benigna del pelo que afecta predominantemente a niñas rubias y que se caracteriza por la presencia de pelo que puede arrancarse fácilmente y sin dolor. La mayoría del pelo está en la fase anágena y carece de una vaina epitelial externa. El pelo crece de nuevo rápidamente y la enfermedad mejora espontáneamente con la edad. El cabello anágeno suelto puede estar asociado con otras anomalías, como un coloboma.","Spanish_Disease_Name__c":"síndrome del cabello anágeno suelto","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:89826","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Loose anagen syndrome is a rare benign hair disorder affecting predominantly blond females in childhood and characterized by the presence of hair that can be easily and painlessly pulled out. Most of the hair is in the anagen phase and lacks an external epithelial sheath. Hair grows back quickly and the condition improves spontaneously with aging. Loose anagen hair can be associated with other anomalies, such as coloboma.","Curated_Disease_Description_Source__c":"MONDO:0010908","GARD_Synonym__c":"loose anagen syndrome","Name":"Loose anagen hair syndrome","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Genetics","Tag_Category__c":"Cause;Disease Category;Specialist","category_description":"Genetic diseases affect the DNA, or genetic instructions, which directs how tissues, organs, and body systems function.","curated_tag_name":"Genetic diseases"},{"Tag_Name__c":"Dermatology","Tag_Category__c":"Account;Disease Category;Specialist","category_description":"Skin diseases, or integumentary system diseases, affect the skin, hair, nails, sweat glands, or oil glands.","curated_tag_name":"Skin diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Childhood","Provided_By__c":"ORPHA:168"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.omim.org/entry/600628","Source__c":"C0406468; MONDO:0010908; ORPHA:168","Xref__c":"OMIM:600628"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0111702","Source__c":"MONDO:0010908","Xref__c":"DOID:0111702"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=238735005","Source__c":"C0406468; MONDO:0010908","Xref__c":"238735005"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0406468","Source__c":"C0406468","Xref__c":"C0406468"},{"URL__c":"https://www.orpha.net/en/disease/detail/168","Source__c":"C0406468; MONDO:0010908; ORPHA:168","Xref__c":"ORPHA:168"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=98351","Source__c":"C0406468","Xref__c":"MEDGEN:98351"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C058247","Source__c":"C0406468; MONDO:0010908","Xref__c":"D058247"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0010908","Source__c":"GARD:0003287","Xref__c":"MONDO:0010908"}],"Inheritance__c":["Autosomal dominant"],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:168","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"An abnormal hair whorl (that is, a patch of hair growing in the opposite direction of the rest of the hair).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0010721","HPO_Synonym__c":"Abnormal hair whorl; Abnormal hair whorls; Abnormal whorl of hair","HPO_Name__c":"Abnormal hair whorl","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:168","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"A coloboma of the iris.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000612","HPO_Synonym__c":"Cat eye; Coloboma of iris; Coloboma of the iris; Keyhole iris","HPO_Name__c":"Iris coloboma","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:168","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"An abnormality of the hair.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001595","HPO_Synonym__c":"Abnormality of the hair; Hair abnormality","HPO_Name__c":"Abnormal hair morphology","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Cause":["Genetics"],"Disease Category":["Genetics","Dermatology"],"Specialist":["Genetics","Dermatology","Pediatrics"],"Account":["Dermatology"]},"synonyms":["loose anagen syndrome"]}