{"Name":"Yolk sac tumor","DiseaseID__c":"GARD:0000348","id":348,"encodedName":"yolk-sac-tumor","IsDeleted":false,"Disease_Name_Full__c":"Yolk sac tumor","Xref_IDs__c":"404081005; C0014145; C3011; DOID:1911; MEDGEN:41782; MONDO:0005744; ORPHA:876","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":2,"Description_Source__c":"MONDO:0005744","Disease_Description__c":"A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It is the most common malignant germ cell tumor in the pediatric population. It occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment includes: surgical resection, radiation, and chemotherapy. This tumor is very responsive to chemotherapy regimens that include cisplatinum.","GARD_Name__c":"Yolk sac tumor","GARD_Synonym__c":"embryonal carcinoma, infantile; endodermal sinus neoplasm; endodermal sinus tumor; endodermal sinus tumour; hepatoid yolk sac tumor; hepatoid yolk sac tumour; infantile embryonal carcinoma; orchioblastoma; polyvesicular vitelline tumor; yolk sac neoplasm; yolk sac tumor site unspecified; yolk sac tumor, malignant; yolk sac tumour; yolk sac tumour site unspecified","Curated_Disease_Description_Source__c":"MONDO:0005744","Curated_Disease_Description__c":"A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It is the most common malignant germ cell tumor in the pediatric population. It occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment includes: surgical resection, radiation, and chemotherapy. This tumor is very responsive to chemotherapy regimens that include cisplatinum.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"as a Teenager and as an Adult","SourceID__c":"ORPHA:876","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0005744","ORPHANET_ID__c":"ORPHA:876","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Tumor de saco vitelino","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"tumor de saco vitelino","Spanish_GARD_Synonym__c":"tumor de seno endodérmico","Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It is the most common malignant germ cell tumor in the pediatric population. It occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment includes: surgical resection, radiation, and chemotherapy. This tumor is very responsive to chemotherapy regimens that include cisplatinum.","Curated_Disease_Description_Source__c":"MONDO:0005744","GARD_Synonym__c":"embryonal carcinoma, infantile; endodermal sinus neoplasm; endodermal sinus tumor; endodermal sinus tumour; hepatoid yolk sac tumor; hepatoid yolk sac tumour; infantile embryonal carcinoma; orchioblastoma; polyvesicular vitelline tumor; yolk sac neoplasm; yolk sac tumor site unspecified; yolk sac tumor, malignant; yolk sac tumour; yolk sac tumour site unspecified","Name":"Yolk sac tumor","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"National Ovarian Cancer Coalition","Website__c":"https://ovarian.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adolescent","Provided_By__c":"ORPHA:876"},{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:876"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0014145","Source__c":"C0014145","Xref__c":"C0014145"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A1911","Source__c":"MONDO:0005744","Xref__c":"DOID:1911"},{"URL__c":"https://www.orpha.net/en/disease/detail/876","Source__c":"C0014145; MONDO:0005744; ORPHA:876","Xref__c":"ORPHA:876"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3011","Source__c":"C0014145; MONDO:0005744","Xref__c":"C3011"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=404081005","Source__c":"C0014145; MONDO:0005744","Xref__c":"404081005"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=41782","Source__c":"C0014145","Xref__c":"MEDGEN:41782"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0005744","Source__c":"GARD:0000348","Xref__c":"MONDO:0005744"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=74409009","Source__c":"C0014145","Xref__c":"74409009"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C018240","Source__c":"C0014145","Xref__c":"D018240"}],"tags":{"Specialist":["Cancer - Oncologist","Pediatrics"],"Disease Category":["Cancer"]},"synonyms":["embryonal carcinoma, infantile"," endodermal sinus neoplasm"," endodermal sinus tumor"," endodermal sinus tumour"," hepatoid yolk sac tumor"," hepatoid yolk sac tumour"," infantile embryonal carcinoma"," orchioblastoma"," polyvesicular vitelline tumor"," yolk sac neoplasm"," yolk sac tumor site unspecified"," yolk sac tumor, malignant"," yolk sac tumour"," yolk sac tumour site unspecified"]}