{"Name":"Fetal parvovirus syndrome","DiseaseID__c":"GARD:0004236","id":4236,"encodedName":"fetal-parvovirus-syndrome","IsDeleted":false,"Disease_Name_Full__c":"Fetal parvovirus syndrome","Xref_IDs__c":"715197005; C2931167; C536301; MEDGEN:443992; MONDO:0017453; ORPHA:295","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":4,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":6,"No_of_Age_at_Onset__c":2,"Description_Source__c":"MONDO:0017453","Disease_Description__c":"Foetal parvovirus syndrome is a foetopathy likely to occur when a pregnant woman is infected by parvovirus B19. In adults, the virus causes a butterfly erythema infectiosum (also called Fifth Disease; 'slapped cheek disease') and flu-like symptoms with symmetric polyarthralgias, which usually do not warrant prenatal diagnosis.","GARD_Name__c":"Fetal parvovirus syndrome","GARD_Synonym__c":"foetal parvovirus syndrome; human parvovirus b19 caused infectious embryofetopathy; human parvovirus b19 infectious embryofetopathy; mother-to-child transmission of parvovirus syndrome; parvovirus antenatal infection","Curated_Disease_Description_Source__c":"Source data grammar correction","Curated_Disease_Description__c":"Fetal parvovirus syndrome is a fetopathy likely to occur when a pregnant woman is infected by parvovirus B19. In adults, the virus causes a butterfly erythema infectiosum (also called Fifth Disease; 'slapped cheek disease') and flu-like symptoms with symmetric polyarthralgias, which usually do not warrant prenatal diagnosis.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"during Pregnancy and as a Newborn","SourceID__c":"ORPHA:295","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0017453","ORPHANET_ID__c":"ORPHA:295","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Síndrome de parvovirus fetal","Spanish_Description_Source__c":"ORPHA:295","Spanish_Description__c":"El síndrome por parvovirus es una fetopatía que se puede producir cuando una mujer embarazada se infecta con parvovirus B19. En adultos causa un eritema infeccioso en mariposa (también llamado Quinta enfermedad; 'enfermedad de la bofetada en la mejilla'), y síntomas parecidos a la gripe con poliartralgia simétrica, que generalmente no permiten un diagnóstico prenatal.","Spanish_Disease_Name__c":"síndrome de parvovirus fetal","Spanish_GARD_Synonym__c":"infección prenatal por parvovirus; transmisión materna del síndrome de parvovirus","Category_Linearization__c":"ORPHA:93890","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Fetal parvovirus syndrome is a fetopathy likely to occur when a pregnant woman is infected by parvovirus B19. In adults, the virus causes a butterfly erythema infectiosum (also called Fifth Disease; 'slapped cheek disease') and flu-like symptoms with symmetric polyarthralgias, which usually do not warrant prenatal diagnosis.","Curated_Disease_Description_Source__c":"Source data grammar correction","GARD_Synonym__c":"foetal parvovirus syndrome; human parvovirus b19 caused infectious embryofetopathy; human parvovirus b19 infectious embryofetopathy; mother-to-child transmission of parvovirus syndrome; parvovirus antenatal infection","Name":"Fetal parvovirus syndrome","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Infectious Disease","Tag_Category__c":"Disease Category;Specialist","category_description":"Infectious diseases are caused by bacteria, viruses, fungi, or parasites entering the body, multiplying, and spreading illness.","curated_tag_name":"Infectious diseases"},{"Tag_Name__c":"Genetics","Tag_Category__c":"Cause;Disease Category;Specialist","category_description":"Genetic diseases affect the DNA, or genetic instructions, which directs how tissues, organs, and body systems function.","curated_tag_name":"Genetic diseases"},{"Tag_Name__c":"Congenital Abnormality","Tag_Category__c":"Disease Category","category_description":"Birth defects are structural changes present at birth that can affect almost any part of the body, including how the body looks, works, or both.","curated_tag_name":"Birth defects"},{"Tag_Name__c":"Otolaryngology","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Craniofacial Anomalies","Tag_Category__c":"Account","curated_tag_name":"Craniofacial anomalies"},{"Tag_Name__c":"Infectious Embryofetopathy","Tag_Category__c":"Cause","curated_tag_name":"Congenital Infectious Diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Antenatal","Provided_By__c":"ORPHA:295"},{"Age_At_Onset__c":"Neonatal","Provided_By__c":"ORPHA:295"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C536301","Source__c":"MONDO:0017453","Xref__c":"C536301"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=715197005","Source__c":"C2931167; MONDO:0017453","Xref__c":"715197005"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C2931167","Source__c":"C2931167","Xref__c":"C2931167"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=443992","Source__c":"C2931167","Xref__c":"MEDGEN:443992"},{"URL__c":"https://www.orpha.net/en/disease/detail/295","Source__c":"C2931167; MONDO:0017453; ORPHA:295","Xref__c":"ORPHA:295"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0017453","Source__c":"GARD:0004236","Xref__c":"MONDO:0017453"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:295","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001511","HPO_Synonym__c":"Fetal growth restriction; FGR; In utero growth retardation; Intrauterine growth failure; Intrauterine growth restriction; Intrauterine growth retardation, IUGR; Intrauterine retardation; IUGR; Prenatal growth deficiency; Prenatal growth failure; Prenatal growth retardation; Prenatal onset growth retardation; Prenatal-onset growth retardation; Small for gestational age infant","HPO_Name__c":"Intrauterine growth retardation","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:295","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"A reduction in erythrocytes volume or hemoglobin concentration.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001903","HPO_Synonym__c":"Anaemia; Low number of red blood cells or hemoglobin","HPO_Name__c":"Anemia","Feature_System__c":"Blood and Blood-Forming Tissue","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:295","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Abnormality of eyesight (visual perception).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000504","HPO_Synonym__c":"Abnormality of sight; Abnormality of vision; Vision issue","HPO_Name__c":"Abnormality of vision","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:295","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Hypertrophic cardiomyopathy (HCM) is defined by the presence of increased ventricular wall thickness or mass in the absence of loading conditions (hypertension, valve disease) sufficient to cause the observed abnormality.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001639","HPO_Synonym__c":"Cardiomyopathy, hypertrophic; Enlarged and thickened heart muscle; HCM","HPO_Name__c":"Hypertrophic cardiomyopathy","Feature_System__c":"Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:295","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Accumulation of fluid in the peritoneal cavity (between the layers of the peritoneum that lines the abdomen).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001541","HPO_Synonym__c":"Accumulation of fluid in the abdomen; Peritoneal effusion","HPO_Name__c":"Ascites","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:295","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Nuchal translucency is the sonographic appearance of subcutaneous accumulation of liquid in the back of the fetal neck in the first trimester of pregnancy (11-14 gestational weeks of pregnancy).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0010880","HPO_Name__c":"Increased nuchal translucency","HPO_Feature_Type__c":"Imaging_Ultrasound_Fetal"}},{"Provided_By__c":"ORPHA:295","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"A reduction in the number of circulating thrombocytes.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001873","HPO_Synonym__c":"Low platelet count","HPO_Name__c":"Thrombocytopenia","Feature_System__c":"Blood and Blood-Forming Tissue","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:295","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001789","HPO_Name__c":"Hydrops fetalis","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:295","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Any abnormality of the eye, including location, spacing, and intraocular abnormalities.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000478","HPO_Synonym__c":"Abnormal eye; Abnormality of the eye","HPO_Name__c":"Abnormality of the eye","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Disease Category":["Infectious Disease","Genetics","Congenital Abnormality"],"Specialist":["Infectious Disease","Genetics","Otolaryngology","Pediatrics"],"Cause":["Genetics","Infectious Embryofetopathy"],"Account":["Craniofacial Anomalies"]},"synonyms":["foetal parvovirus syndrome"," human parvovirus b19 caused infectious embryofetopathy"," human parvovirus b19 infectious embryofetopathy"," mother-to-child transmission of parvovirus syndrome"," parvovirus antenatal infection"]}