{"Name":"Complex regional pain syndrome","DiseaseID__c":"GARD:0004647","id":4647,"encodedName":"complex-regional-pain-syndrome","IsDeleted":false,"Disease_Name_Full__c":"Complex regional pain syndrome","Xref_IDs__c":"128200000; C0458219; C206547; D020918; DOID:14022; DOID:3223; M89.0; MEDGEN:96846; MONDO:0019369; ORPHA:83452","USA_Estimate__c":"200,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":2,"World_Estimate__c":"800,000 to 5,000,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":2,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0019369","Disease_Description__c":"Complex regional pain syndrome (CRPS) is a rare neurologic disease painful progressive condition that corresponds to a group of disorders characterized by a disproportionate spontaneous or stimulus-induced pain, accompanied by a variably mixed myriad of autonomic and motor disorders including symptoms such as swelling, allodynia, skin blood supply and trophic disturbances. CRPS most often affects one of the arms, legs, hands, or feet and usually occurs after an injury or trauma to that limb.","GARD_Name__c":"Complex regional pain syndrome","GARD_Synonym__c":"algodystrophy; algoneurodystrophy; complex regional pain syndromes; crps; crps - complex regional pain syndrome","Curated_Disease_Description_Source__c":"GARD:0004647","Curated_Disease_Description__c":"Complex regional pain syndrome (CRPS) is a chronic pain condition that mainly affects the arms, legs, hands, and feet, but may involve the entire body. CRPS symptoms often begin after surgery or an injury. The main feature of CRPS is continuous, intense pain that is out of proportion to the severity of the injury. The pain gets worse over time and often spreads throughout the entire affected area. Other symptoms may include color and temperature changes of the skin over the affected area, skin sensitivity, sweating, and swelling. The underlying cause of CRPS is often not known.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"200,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:83452","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0019369","ORPHANET_ID__c":"ORPHA:83452","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Síndrome de dolor regional complejo","Spanish_Description_Source__c":"ORPHA:83452","Spanish_Description__c":"El síndrome de dolor regional complejo (SDRC) es una enfermedad neurológica dolorosa progresiva poco común que corresponde a un grupo de trastornos caracterizados por dolor desproporcionado, espontáneo o inducido por estímulos, acompañado de una miríada variable de trastornos autonómicos y motores que incluyen síntomas como hinchazón, alodinia, irrigación cutánea y alteraciones tróficas. El SDRC afecta con mayor frecuencia a los brazos, piernas, manos o pies de forma unilateral y suele ocurrir después de una lesión o trauma en esa extremidad.","Spanish_Disease_Name__c":"síndrome de dolor regional complejo","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:98006","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Complex regional pain syndrome (CRPS) is a chronic pain condition that mainly affects the arms, legs, hands, and feet, but may involve the entire body. CRPS symptoms often begin after surgery or an injury. The main feature of CRPS is continuous, intense pain that is out of proportion to the severity of the injury. The pain gets worse over time and often spreads throughout the entire affected area. Other symptoms may include color and temperature changes of the skin over the affected area, skin sensitivity, sweating, and swelling. The underlying cause of CRPS is often not known.","Curated_Disease_Description_Source__c":"GARD:0004647","GARD_Synonym__c":"algodystrophy; algoneurodystrophy; complex regional pain syndromes; crps; crps - complex regional pain syndrome","Name":"Complex regional pain syndrome","Curated_USA_Estimate__c":"200,000","estimateUsa":"200,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Autoimmune Registry","Website__c":"https://www.autoimmuneregistry.org/"},{"Account_Name__c":"Brain & Spine Foundation","Website__c":"https://www.brainandspine.org.uk/"},{"Account_Name__c":"American Chronic Pain Association","Website__c":"https://www.acpanow.com/"},{"Account_Name__c":"Reflex Sympathetic Dystrophy Syndrome Association","Website__c":"https://rsds.org/"},{"Account_Name__c":"CRPS Forum","Website__c":"https://crpsforumcork.com/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:83452"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0458219","Source__c":"C0458219","Xref__c":"C0458219"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=128200000","Source__c":"C0458219; MONDO:0019369","Xref__c":"128200000"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A3223","Source__c":"MONDO:0019369","Xref__c":"DOID:3223"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C020918","Source__c":"C0458219; MONDO:0019369","Xref__c":"D020918"},{"URL__c":"https://www.orpha.net/en/disease/detail/83452","Source__c":"C0458219; MONDO:0019369; ORPHA:83452","Xref__c":"ORPHA:83452"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=96846","Source__c":"C0458219","Xref__c":"MEDGEN:96846"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0019369","Source__c":"GARD:0004647","Xref__c":"MONDO:0019369"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C206547","Source__c":"C0458219","Xref__c":"C206547"},{"URL__c":"https://www.ninds.nih.gov/health-information/disorders/complex-regional-pain-syndrome"},{"URL__c":"https://medlineplus.gov/complexregionalpainsyndrome.html"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/M89.0","Source__c":"MONDO:0019369","Xref__c":"M89.0"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A14022","Source__c":"MONDO:0019369","Xref__c":"DOID:14022"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:83452","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An abnormal accumulation of excess fluid in the lower extremity resulting in swelling of the feet and extending upward to the lower leg.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0010741","HPO_Synonym__c":"Edema of the lower limbs; Fluid accumulation in lower limbs; Leg edema; Lower leg swelling; Peripheral edema of lower extremity","HPO_Name__c":"Pedal edema","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:83452","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Painful sensations elicited by a nonpainful cutaneous stimulus such as a light touch or gentle stroking over affected areas of the body. Sometimes referred to as hyperpathia or hyperalgesia. Often perceived as an intense burning, dyesthesias may outlast the stimulus by several seconds.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012534","HPO_Synonym__c":"Dysaesthesia; Hyperalgesia; Hyperpathia","HPO_Name__c":"Dysesthesia","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:83452","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Skin characterized by the lack of natural or normal moisture.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000958","HPO_Synonym__c":"Dry skin; Xerosis","HPO_Name__c":"Dry skin","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:83452","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Trophic changes is a term used to describe abnormalities in the area of pain that include primarily wasting away of the skin, tissues, or muscle, thinning of the bones, and changes in how the hair or nails grow, including thickening or thinning of hair or brittle nails.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0010834","HPO_Synonym__c":"Trophic changes","HPO_Name__c":"Trophic changes related to pain","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:83452","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An abnormal accumulation of fluid beneath the skin of the arms.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0010742","HPO_Synonym__c":"Fluid accumulation in upper limbs","HPO_Name__c":"Edema of the upper limbs","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:83452","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An abnormality of the primary sensation that is mediated by peripheral nerves (pain, temperature, touch, vibration, joint position). The word hypoesthesia (or hypesthesia) refers to a reduction in cutaneous sensation to a specific type of testing.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0003474","HPO_Synonym__c":"Sensory impairment","HPO_Name__c":"Somatic sensory dysfunction","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:83452","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Pain due to a stimulus that does not normally provoke pain.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012533","HPO_Name__c":"Allodynia","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:83452","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Involuntary contractions of muscle leading to involuntary movements of extremities, neck, trunk, or face.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0004305","HPO_Synonym__c":"Involuntary movements; Involuntary muscle contractions","HPO_Name__c":"Involuntary movements","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:83452","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Chronic pain in the limbs with no clear focal etiology.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0009763","HPO_Synonym__c":"Limb pain","HPO_Name__c":"Limb pain","Feature_System__c":"Musculoskeletal System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:83452","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Redness of the skin, caused by hyperemia of the capillaries in the lower layers of the skin.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0010783","HPO_Synonym__c":"Redness of skin or mucous membrane","HPO_Name__c":"Erythema","Feature_System__c":"Skin System; Cardiovascular System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:83452","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Nails whose growth is slower than normal.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0008383","HPO_Synonym__c":"Slow-growing nails","HPO_Name__c":"Slow-growing nails","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:83452","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0040170","HPO_Name__c":"Abnormality of hair growth","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Disease Category":["Neurology"],"Specialist":["Neurology","Pediatrics"]},"synonyms":["algodystrophy"," algoneurodystrophy"," complex regional pain syndromes"," crps"," crps - complex regional pain syndrome"]}