{"Name":"Embryonal carcinoma","DiseaseID__c":"GARD:0005140","id":5140,"encodedName":"embryonal-carcinoma","IsDeleted":false,"Disease_Name_Full__c":"Embryonal carcinoma","Xref_IDs__c":"1156454002; 28047004; C0206659; C3752; D018236; DOID:3308; MEDGEN:61653; MONDO:0005440; ORPHA:180226","USA_Estimate__c":"1,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"1 to 8,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":2,"Description_Source__c":"MONDO:0005440","Disease_Description__c":"A non-seminomatous malignant germ cell tumor characterized by the presence of large germ cells with abundant cytoplasm resembling epithelial cells, geographic necrosis, high mitotic activity, and pseudoglandular and pseudopapillary structures formation. It can arise from the testis, ovary, and extragonadal sites (central nervous system and mediastinum).","GARD_Name__c":"Embryonal carcinoma","GARD_Synonym__c":"carcinoma, embryonal, malignant; embryonal adenocarcinoma","Curated_Disease_Description_Source__c":"GARD:0005140","Curated_Disease_Description__c":"Embryonal carcinoma is a type of testicular cancer, which is cancer that starts in the testicles, the male reproductive glands located in the scrotum. It most often develops in young and middle-aged men. It tends to grow rapidly and spread outside the testicle. Embryonal carcinomas are classified as nonseminoma germ cell tumors. Most testicular cancers grow from germ cells, the cells that make sperm. Germ cell tumors are broadly divided into seminomas and nonseminomas because each type has a different prognosis and treatment regimen. Nonseminomas, which are more common, tend to grow more quickly than seminomas. Nonseminoma tumors are often made up of more than one type of cell, and are identified according to the different cell types.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"1,000","Age_at_Onset_Snippet_Text__c":"as a Child and as a Teenager","SourceID__c":"ORPHA:180226","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0005440","ORPHANET_ID__c":"ORPHA:180226","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Carcinoma embrionario","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"carcinoma embrionario","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Embryonal carcinoma is a type of testicular cancer, which is cancer that starts in the testicles, the male reproductive glands located in the scrotum. It most often develops in young and middle-aged men. It tends to grow rapidly and spread outside the testicle. Embryonal carcinomas are classified as nonseminoma germ cell tumors. Most testicular cancers grow from germ cells, the cells that make sperm. Germ cell tumors are broadly divided into seminomas and nonseminomas because each type has a different prognosis and treatment regimen. Nonseminomas, which are more common, tend to grow more quickly than seminomas. Nonseminoma tumors are often made up of more than one type of cell, and are identified according to the different cell types.","Curated_Disease_Description_Source__c":"GARD:0005140","GARD_Synonym__c":"carcinoma, embryonal, malignant; embryonal adenocarcinoma","Name":"Embryonal carcinoma","Curated_USA_Estimate__c":"1,000","estimateUsa":"1,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Pediatric Brain Tumor Foundation","Website__c":"https://www.curethekids.org/"},{"Account_Name__c":"Testicular Cancer Society","Website__c":"http://www.testicularcancersociety.org/"},{"Account_Name__c":"American Cancer Society","Website__c":"https://www.cancer.org"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adolescent","Provided_By__c":"ORPHA:180226"},{"Age_At_Onset__c":"Childhood","Provided_By__c":"ORPHA:180226"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.orpha.net/en/disease/detail/180226","Source__c":"C0206659; MONDO:0005440; ORPHA:180226","Xref__c":"ORPHA:180226"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A3308","Source__c":"MONDO:0005440","Xref__c":"DOID:3308"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3752","Source__c":"C0206659; MONDO:0005440","Xref__c":"C3752"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=61653","Source__c":"C0206659","Xref__c":"MEDGEN:61653"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0206659","Source__c":"C0206659","Xref__c":"C0206659"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C018236","Source__c":"C0206659; MONDO:0005440","Xref__c":"D018236"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0005440","Source__c":"GARD:0005140","Xref__c":"MONDO:0005440"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=1156454002","Source__c":"C0206659","Xref__c":"1156454002"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=28047004","Source__c":"C0206659","Xref__c":"28047004"}],"tags":{"Specialist":["Cancer - Oncologist","Pediatrics"],"Disease Category":["Cancer"]},"synonyms":["carcinoma, embryonal, malignant"," embryonal adenocarcinoma"]}