{"Name":"Acute lymphoid leukemia","DiseaseID__c":"GARD:0000522","id":522,"encodedName":"acute-lymphoid-leukemia","IsDeleted":false,"Disease_Name_Full__c":"Acute lymphoid leukemia","Xref_IDs__c":"91857003; C0023449; C3167; C91.0; DOID:9952; MEDGEN:7317; MONDO:0004967; ORPHA:513","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":3,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":3,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0004967","Disease_Description__c":"Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia.","GARD_Name__c":"Acute lymphoid leukemia","GARD_Synonym__c":"acute lymphatic leukaemia; acute lymphatic leukemia; acute lymphoblastic leukaemia; acute lymphoblastic leukaemia (all); acute lymphoblastic leukaemia (disease); acute lymphoblastic leukemia; acute lymphoblastic leukemia (all); acute lymphoblastic leukemia (disease); acute lymphoblastic leukemia/lymphoma; acute lymphocytic leukaemia; acute lymphocytic leukemia; acute lymphocytic leukemias; acute lymphogenous leukaemia; acute lymphogenous leukemia; acute lymphoid leukaemia; acute lymphoid leukemia, disease; all; all - acute lymphoblastic leukemia; all - acute lymphocytic leukaemia; all - acute lymphocytic leukemia; familial acute lymphocytic leukemia; leukemia, acute lymphoblastic, somatic; leukemia, lymphoblastic, malignant; lymphoblastic leukemia; lymphoblastic leukemia, acute; precursor cell lymphoblastic leukaemia; precursor cell lymphoblastic leukemia; precursor lymphoblasic leukaemia; precursor lymphoblasic leukemia; precursor lymphoblastic leukaemia; precursor lymphoblastic leukemia","Curated_Disease_Description_Source__c":"GARD:0000522","Curated_Disease_Description__c":"Acute lymphoblastic leukemia (ALL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). It may develop in children or adults. ALL spreads to the blood and then may spread to other areas of the body such as the lymph nodes, liver, spleen, central nervous system, and testicles (in males). Signs and symptoms of ALL may include fever, easy bruising or bleeding, feeling tired, loss of appetite, pain in the bones or abdomen, and painless lumps in the neck, underarm, stomach, or groin. ALL is typically caused by random, non-inherited changes in the DNA of immature lymphocytes called lymphoblasts. However, some people may inherit a genetic susceptibility to developing ALL. The risk to develop ALL may also be increased by past treatment for cancer and by having certain genetic conditions or syndromes. Having one or more risk factors does not mean that a person definitely will develop ALL.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"at any time in life","SourceID__c":"ORPHA:513","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0004967","ORPHANET_ID__c":"ORPHA:513","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Leucemia linfoblástica aguda","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"leucemia linfoblástica aguda","Spanish_GARD_Synonym__c":"leucemia linfocítica aguda; leucemia/linfoma linfoblástico agudo; lla; neoplasia de células precursoras linfoides","Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Acute lymphoblastic leukemia (ALL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). It may develop in children or adults. ALL spreads to the blood and then may spread to other areas of the body such as the lymph nodes, liver, spleen, central nervous system, and testicles (in males). Signs and symptoms of ALL may include fever, easy bruising or bleeding, feeling tired, loss of appetite, pain in the bones or abdomen, and painless lumps in the neck, underarm, stomach, or groin. ALL is typically caused by random, non-inherited changes in the DNA of immature lymphocytes called lymphoblasts. However, some people may inherit a genetic susceptibility to developing ALL. The risk to develop ALL may also be increased by past treatment for cancer and by having certain genetic conditions or syndromes. Having one or more risk factors does not mean that a person definitely will develop ALL.","Curated_Disease_Description_Source__c":"GARD:0000522","GARD_Synonym__c":"acute lymphatic leukaemia; acute lymphatic leukemia; acute lymphoblastic leukaemia; acute lymphoblastic leukaemia (all); acute lymphoblastic leukaemia (disease); acute lymphoblastic leukemia; acute lymphoblastic leukemia (all); acute lymphoblastic leukemia (disease); acute lymphoblastic leukemia/lymphoma; acute lymphocytic leukaemia; acute lymphocytic leukemia; acute lymphocytic leukemias; acute lymphogenous leukaemia; acute lymphogenous leukemia; acute lymphoid leukaemia; acute lymphoid leukemia, disease; all; all - acute lymphoblastic leukemia; all - acute lymphocytic leukaemia; all - acute lymphocytic leukemia; familial acute lymphocytic leukemia; leukemia, acute lymphoblastic, somatic; leukemia, lymphoblastic, malignant; lymphoblastic leukemia; lymphoblastic leukemia, acute; precursor cell lymphoblastic leukaemia; precursor cell lymphoblastic leukemia; precursor lymphoblasic leukaemia; precursor lymphoblasic leukemia; precursor lymphoblastic leukaemia; precursor lymphoblastic leukemia","Name":"Acute lymphoid leukemia","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"HealthTree Foundation","Website__c":"https://healthtree.org/"},{"Account_Name__c":"American Cancer Society","Website__c":"https://www.cancer.org"},{"Account_Name__c":"Blood Cancer United","Website__c":"https://bloodcancerunited.org/"},{"Account_Name__c":"Leukaemia Foundation","Website__c":"https://www.leukaemia.org.au/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Hematology","Tag_Category__c":"Disease Category;Specialist","category_description":"Blood diseases affect the blood or blood-forming organs, including red blood cells, white blood cells, platelets, plasma, and bone marrow.","curated_tag_name":"Blood diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"All ages","Provided_By__c":"ORPHA:513"}],"Diagnosis__c":[{"Type__c":"GTR","Curie__c":"MEDGEN:C2751595"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A9952","Source__c":"MONDO:0004967","Xref__c":"DOID:9952"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=7317","Source__c":"C0023449","Xref__c":"MEDGEN:7317"},{"URL__c":"https://www.orpha.net/en/disease/detail/513","Source__c":"C0023449; MONDO:0004967","Xref__c":"ORPHA:513"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=91857003","Source__c":"C0023449; MONDO:0004967","Xref__c":"91857003"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0023449","Source__c":"C0023449","Xref__c":"C0023449"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3167","Source__c":"C0023449; MONDO:0004967","Xref__c":"C3167"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0006721","Source__c":"C0023449","Xref__c":"HP:0006721"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0004967","Source__c":"GARD:0000522","Xref__c":"MONDO:0004967"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/C91.0","Source__c":"MONDO:0004967","Xref__c":"C91.0"},{"URL__c":"https://www.cancer.gov/types/leukemia/patient/adult-all-treatment-pdq"},{"URL__c":"https://www.cancer.gov/types/leukemia"},{"URL__c":"https://medlineplus.gov/acutelymphocyticleukemia.html"}],"GARD_Disease_Gene__c":[{"GeneSymbol__c":"TAL1","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"NUP214","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"BCR","GHR_URL__c":"https://medlineplus.gov/genetics/gene/bcr","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"BAX","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"GNB1","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"TAL2","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"FLT3","GHR_URL__c":"https://medlineplus.gov/genetics/gene/flt3","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"NBN","GHR_URL__c":"https://medlineplus.gov/genetics/gene/nbn","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true}],"tags":{"Specialist":["Cancer - Oncologist","Hematology","Pediatrics"],"Disease Category":["Cancer","Hematology"]},"synonyms":["acute lymphatic leukaemia"," acute lymphatic leukemia"," acute lymphoblastic leukaemia"," acute lymphoblastic leukaemia (all)"," acute lymphoblastic leukaemia (disease)"," acute lymphoblastic leukemia"," acute lymphoblastic leukemia (all)"," acute lymphoblastic leukemia (disease)"," acute lymphoblastic leukemia/lymphoma"," acute lymphocytic leukaemia"," acute lymphocytic leukemia"," acute lymphocytic leukemias"," acute lymphogenous leukaemia"," acute lymphogenous leukemia"," acute lymphoid leukaemia"," acute lymphoid leukemia, disease"," all"," all - acute lymphoblastic leukemia"," all - acute lymphocytic leukaemia"," all - acute lymphocytic leukemia"," familial acute lymphocytic leukemia"," leukemia, acute lymphoblastic, somatic"," leukemia, lymphoblastic, malignant"," lymphoblastic leukemia"," lymphoblastic leukemia, acute"," precursor cell lymphoblastic leukaemia"," precursor cell lymphoblastic leukemia"," precursor lymphoblasic leukaemia"," precursor lymphoblasic leukemia"," precursor lymphoblastic leukaemia"," precursor lymphoblastic leukemia"]}