{"Name":"Acute myeloblastic leukemia without maturation","DiseaseID__c":"GARD:0000526","id":526,"encodedName":"acute-myeloblastic-leukemia-without-maturation","IsDeleted":false,"Disease_Name_Full__c":"Acute myeloblastic leukemia without maturation","Xref_IDs__c":"359640008; C0026998; C3249; DOID:0081086; MEDGEN:10232; MONDO:0005224; ORPHA:98833","USA_Estimate__c":"1,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"1 to 8,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0005224","Disease_Description__c":"An acute myeloid leukemia (AML) characterized by blasts without evidence of maturation to more mature neutrophils. (WHO, 2001)","GARD_Name__c":"Acute myeloblastic leukemia without maturation","GARD_Synonym__c":"acute granulocytic leukaemia without maturation; acute granulocytic leukemia without maturation; acute m1 myeloid leukaemia; acute m1 myeloid leukemia; acute myeloblastic leukaemia m1; acute myeloblastic leukemia m1; acute myelocytic leukaemia without maturation; acute myelocytic leukemia without maturation; acute myelogenous leukaemia without maturation; acute myelogenous leukemia without maturation; acute myeloid leukaemia without maturation; acute myeloid leukaemia without maturation (fab m1); acute myeloid leukemia without maturation; acute myeloid leukemia without maturation (fab m1); acute myeloid leukemia without maturation, fab m1; aml m1; aml without maturation; fab m1; m1 - acute myeloblastic leukemia without maturation; m1 acute granulocytic leukaemia; m1 acute granulocytic leukaemia without maturation; m1 acute granulocytic leukemia; m1 acute granulocytic leukemia without maturation; m1 acute myeloblastic leukaemia; m1 acute myeloblastic leukaemia without maturation; m1 acute myeloblastic leukemia; m1 acute myeloblastic leukemia without maturation; m1 acute myelocytic leukaemia; m1 acute myelocytic leukaemia without maturation; m1 acute myelocytic leukemia; m1 acute myelocytic leukemia without maturation; m1 acute myelogenous leukaemia; m1 acute myelogenous leukaemia without maturation; m1 acute myelogenous leukemia; m1 acute myelogenous leukemia without maturation; m1 acute myeloid leukaemia; m1 acute myeloid leukaemia without maturation; m1 acute myeloid leukemia; m1 acute myeloid leukemia without maturation","Curated_Disease_Description_Source__c":"MONDO:0005224","Curated_Disease_Description__c":"An acute myeloid leukemia (AML) characterized by blasts without evidence of maturation to more mature neutrophils. (WHO, 2001)","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"1,000","Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:98833","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0005224","ORPHANET_ID__c":"ORPHA:98833","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Leucemia mieloblástica aguda sin maduración","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"leucemia mieloblástica aguda sin maduración","Spanish_GARD_Synonym__c":"aml m1; leucemia mielobástica aguda m1","Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"An acute myeloid leukemia (AML) characterized by blasts without evidence of maturation to more mature neutrophils. (WHO, 2001)","Curated_Disease_Description_Source__c":"MONDO:0005224","GARD_Synonym__c":"acute granulocytic leukaemia without maturation; acute granulocytic leukemia without maturation; acute m1 myeloid leukaemia; acute m1 myeloid leukemia; acute myeloblastic leukaemia m1; acute myeloblastic leukemia m1; acute myelocytic leukaemia without maturation; acute myelocytic leukemia without maturation; acute myelogenous leukaemia without maturation; acute myelogenous leukemia without maturation; acute myeloid leukaemia without maturation; acute myeloid leukaemia without maturation (fab m1); acute myeloid leukemia without maturation; acute myeloid leukemia without maturation (fab m1); acute myeloid leukemia without maturation, fab m1; aml m1; aml without maturation; fab m1; m1 - acute myeloblastic leukemia without maturation; m1 acute granulocytic leukaemia; m1 acute granulocytic leukaemia without maturation; m1 acute granulocytic leukemia; m1 acute granulocytic leukemia without maturation; m1 acute myeloblastic leukaemia; m1 acute myeloblastic leukaemia without maturation; m1 acute myeloblastic leukemia; m1 acute myeloblastic leukemia without maturation; m1 acute myelocytic leukaemia; m1 acute myelocytic leukaemia without maturation; m1 acute myelocytic leukemia; m1 acute myelocytic leukemia without maturation; m1 acute myelogenous leukaemia; m1 acute myelogenous leukaemia without maturation; m1 acute myelogenous leukemia; m1 acute myelogenous leukemia without maturation; m1 acute myeloid leukaemia; m1 acute myeloid leukaemia without maturation; m1 acute myeloid leukemia; m1 acute myeloid leukemia without maturation","Name":"Acute myeloblastic leukemia without maturation","Curated_USA_Estimate__c":"1,000","estimateUsa":"1,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Cancer.net","Website__c":"https://www.cancer.net/"},{"Account_Name__c":"The Leukemia & Lymphoma Society","Website__c":"www.lls.org"},{"Account_Name__c":"Aplastic Anemia and MDS International Foundation","Website__c":"https://www.aamds.org"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Hematology","Tag_Category__c":"Disease Category;Specialist","category_description":"Blood diseases affect the blood or blood-forming organs, including red blood cells, white blood cells, platelets, plasma, and bone marrow.","curated_tag_name":"Blood diseases"},{"Tag_Name__c":"Myeloid hemopathy","Tag_Category__c":"Account","curated_tag_name":"Blood or bone marrow disease"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:98833"}],"External_Identifier_Disease__c":[{"URL__c":"https://raresource.nih.gov/diseases/filter/0000526","Source__c":"RareSource"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=359640008","Source__c":"C0026998; MONDO:0005224","Xref__c":"359640008"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0026998","Source__c":"C0026998","Xref__c":"C0026998"},{"URL__c":"https://www.orpha.net/en/disease/detail/98833","Source__c":"C0026998; MONDO:0005224; ORPHA:98833","Xref__c":"ORPHA:98833"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=10232","Source__c":"C0026998","Xref__c":"MEDGEN:10232"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3249","Source__c":"C0026998; MONDO:0005224","Xref__c":"C3249"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0081086","Source__c":"MONDO:0005224","Xref__c":"DOID:0081086"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=103690005","Source__c":"C0026998","Xref__c":"103690005"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0005224","Source__c":"GARD:0000526","Xref__c":"MONDO:0005224"}],"GARD_Disease_Gene__c":[{"GeneSymbol__c":"FLT3","GHR_URL__c":"https://medlineplus.gov/genetics/gene/flt3","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true},{"GeneSymbol__c":"NPM1","GHR_URL__c":"https://medlineplus.gov/genetics/gene/npm1","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true}],"tags":{"Specialist":["Cancer - Oncologist","Hematology"],"Disease Category":["Cancer","Hematology"],"Account":["Myeloid hemopathy"]},"synonyms":["acute granulocytic leukaemia without maturation"," acute granulocytic leukemia without maturation"," acute m1 myeloid leukaemia"," acute m1 myeloid leukemia"," acute myeloblastic leukaemia m1"," acute myeloblastic leukemia m1"," acute myelocytic leukaemia without maturation"," acute myelocytic leukemia without maturation"," acute myelogenous leukaemia without maturation"," acute myelogenous leukemia without maturation"," acute myeloid leukaemia without maturation"," acute myeloid leukaemia without maturation (fab m1)"," acute myeloid leukemia without maturation"," acute myeloid leukemia without maturation (fab m1)"," acute myeloid leukemia without maturation, fab m1"," aml m1"," aml without maturation"," fab m1"," m1 - acute myeloblastic leukemia without maturation"," m1 acute granulocytic leukaemia"," m1 acute granulocytic leukaemia without maturation"," m1 acute granulocytic leukemia"," m1 acute granulocytic leukemia without maturation"," m1 acute myeloblastic leukaemia"," m1 acute myeloblastic leukaemia without maturation"," m1 acute myeloblastic leukemia"," m1 acute myeloblastic leukemia without maturation"," m1 acute myelocytic leukaemia"," m1 acute myelocytic leukaemia without maturation"," m1 acute myelocytic leukemia"," m1 acute myelocytic leukemia without maturation"," m1 acute myelogenous leukaemia"," m1 acute myelogenous leukaemia without maturation"," m1 acute myelogenous leukemia"," m1 acute myelogenous leukemia without maturation"," m1 acute myeloid leukaemia"," m1 acute myeloid leukaemia without maturation"," m1 acute myeloid leukemia"," m1 acute myeloid leukemia without maturation"]}