{"Name":"Acute myelomonocytic leukemia M4","DiseaseID__c":"GARD:0000529","id":529,"encodedName":"acute-myelomonocytic-leukemia-m4","IsDeleted":false,"Disease_Name_Full__c":"Acute myelomonocytic leukemia M4","Xref_IDs__c":"110005000; C0023479; C7463; C92.5; DOID:0081082; MEDGEN:9732; MONDO:0018871; ORPHA:517","USA_Estimate__c":"5,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"8,000 to 80,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":6,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0018871","Disease_Description__c":"An acute leukemia characterized by the proliferation of both neutrophil and monocyte precursors. (WHO, 2001)","GARD_Name__c":"Acute myelomonocytic leukemia M4","GARD_Synonym__c":"acute m4 myeloid leukaemia; acute m4 myeloid leukemia; acute myelomonocytic leukaemia; acute myelomonocytic leukaemia (fab type m4); acute myelomonocytic leukemia; acute myelomonocytic leukemia (clinical); acute myelomonocytic leukemia (fab type m4); acute myelomonocytic leukemia, fab m4; aml m4; amml; amml - acute myelomonocytic leukemia; ammol; fab m4; m4 - acute myelomonocytic leukemia","Curated_Disease_Description_Source__c":"MONDO:0018871","Curated_Disease_Description__c":"An acute leukemia characterized by the proliferation of both neutrophil and monocyte precursors. (WHO, 2001)","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"5,000","Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:517","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0018871","ORPHANET_ID__c":"ORPHA:517","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Leucemia mielomonocítica aguda","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"leucemia mielomonocítica aguda","Spanish_GARD_Synonym__c":"lma m4; lmma","Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"An acute leukemia characterized by the proliferation of both neutrophil and monocyte precursors. (WHO, 2001)","Curated_Disease_Description_Source__c":"MONDO:0018871","GARD_Synonym__c":"acute m4 myeloid leukaemia; acute m4 myeloid leukemia; acute myelomonocytic leukaemia; acute myelomonocytic leukaemia (fab type m4); acute myelomonocytic leukemia; acute myelomonocytic leukemia (clinical); acute myelomonocytic leukemia (fab type m4); acute myelomonocytic leukemia, fab m4; aml m4; amml; amml - acute myelomonocytic leukemia; ammol; fab m4; m4 - acute myelomonocytic leukemia","Name":"Acute myelomonocytic leukemia M4","Curated_USA_Estimate__c":"5,000","estimateUsa":"5,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Cancer.net","Website__c":"https://www.cancer.net/"},{"Account_Name__c":"American Cancer Society","Website__c":"https://www.cancer.org"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Hematology","Tag_Category__c":"Disease Category;Specialist","category_description":"Blood diseases affect the blood or blood-forming organs, including red blood cells, white blood cells, platelets, plasma, and bone marrow.","curated_tag_name":"Blood diseases"},{"Tag_Name__c":"Myeloid hemopathy","Tag_Category__c":"Account","curated_tag_name":"Blood or bone marrow disease"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:517"}],"Diagnosis__c":[{"Type__c":"GTR","Curie__c":"MEDGEN:C0023479"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.orpha.net/en/disease/detail/517","Source__c":"C0023479; MONDO:0018871; ORPHA:517","Xref__c":"ORPHA:517"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C7463","Source__c":"C0023479; MONDO:0018871","Xref__c":"C7463"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=9732","Source__c":"C0023479","Xref__c":"MEDGEN:9732"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=110005000","Source__c":"C0023479; MONDO:0018871","Xref__c":"110005000"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0023479","Source__c":"C0023479","Xref__c":"C0023479"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0081082","Source__c":"MONDO:0018871","Xref__c":"DOID:0081082"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0004820","Source__c":"C0023479","Xref__c":"HP:0004820"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0018871","Source__c":"GARD:0000529","Xref__c":"MONDO:0018871"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C015479","Source__c":"C0023479","Xref__c":"D015479"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=30962008","Source__c":"C0023479","Xref__c":"30962008"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/C92.5","Source__c":"MONDO:0018871","Xref__c":"C92.5"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:517","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An abnormal susceptibility to bleeding, often referred to as a bleeding diathesis. A bleeding diathesis may be related to vascular, platelet and coagulation defects.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001892","HPO_Synonym__c":"Bleeding diathesis; Bleeding tendency; Hemorrhagic diathesis","HPO_Name__c":"Abnormal bleeding","Feature_System__c":"Blood and Blood-Forming Tissue","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:517","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"An abnormal increase in the number of leukocytes in the blood.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001974","HPO_Synonym__c":"Elevated white blood count; High white blood count; Increased blood leukocyte number; Leukocytosis","HPO_Name__c":"Increased total leukocyte count","Feature_System__c":"Immune System; Blood and Blood-Forming Tissue","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:517","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Abnormally pale skin.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000980","HPO_Name__c":"Pallor","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:517","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Any abnormality of the gingiva (also known as gums).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000168","HPO_Synonym__c":"Abnormality of the gums; Gingival abnormality","HPO_Name__c":"Abnormality of the gingiva","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:517","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Increased count of eosinophils in the blood.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001880","HPO_Synonym__c":"Eosinophilia; High blood eosinophil count; Increased eosinophil count","HPO_Name__c":"Increased total eosinophil count","Feature_System__c":"Immune System; Blood and Blood-Forming Tissue","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:517","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"A reduction in the number of circulating thrombocytes.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001873","HPO_Synonym__c":"Low platelet count","HPO_Name__c":"Thrombocytopenia","Feature_System__c":"Blood and Blood-Forming Tissue","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:517","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Difficult or labored breathing. Dyspnea is a subjective feeling only the patient can rate, e.g., on a Borg scale.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002094","HPO_Synonym__c":"Abnormal breathing; Breathing difficulty; Difficult to breathe; Difficulty breathing; Shortness of breath; Trouble breathing","HPO_Name__c":"Dyspnea","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:517","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Reduction of total body weight.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001824","HPO_Synonym__c":"Loss of weight","HPO_Name__c":"Weight loss","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:517","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"A reduction in erythrocytes volume or hemoglobin concentration.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001903","HPO_Synonym__c":"Anaemia; Low number of red blood cells or hemoglobin","HPO_Name__c":"Anemia","Feature_System__c":"Blood and Blood-Forming Tissue","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Specialist":["Cancer - Oncologist","Hematology"],"Disease Category":["Cancer","Hematology"],"Account":["Myeloid hemopathy"]},"synonyms":["acute m4 myeloid leukaemia"," acute m4 myeloid leukemia"," acute myelomonocytic leukaemia"," acute myelomonocytic leukaemia (fab type m4)"," acute myelomonocytic leukemia"," acute myelomonocytic leukemia (clinical)"," acute myelomonocytic leukemia (fab type m4)"," acute myelomonocytic leukemia, fab m4"," aml m4"," amml"," amml - acute myelomonocytic leukemia"," ammol"," fab m4"," m4 - acute myelomonocytic leukemia"]}