{"Name":"Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)","DiseaseID__c":"GARD:0000536","id":536,"encodedName":"acute-myeloid-leukemia-with-abnormal-bone-marrow-eosinophils-inv16p13q22-or-t1616p13q22","IsDeleted":false,"Disease_Name_Full__c":"Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)","Xref_IDs__c":"C5395080; C9287; MEDGEN:1716406; MONDO:0020316; ORPHA:98829","USA_Estimate__c":"1,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"1 to 8,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0020316","Disease_Description__c":"Acute myelomonocytic leukemia (AMML) is a cancer that typically develops in the bone marrow and blood of older individuals.AMML is one type of acute myeloid leukemia, a group of blood cancers that occur when the amount of white blood cells increases rapidly. Symptoms of AMML often include fatigue (due to anemia) or easy bruising or bleeding (due to thrombocytopenia). The cause of AMML is currently unknown. Treatment typically consists of chemotherapy.","GARD_Name__c":"Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)","GARD_Synonym__c":"acute myeloid leukemia with cbfb::myh11 fusion; acute myeloid leukemia with inv(16)(p13.1q22); acute myeloid leukemia with t(16;16)(p13.1;q22); acute myelomonocytic leukemia - eosinophilic variant; aml with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)","Curated_Disease_Description_Source__c":"GARD:0000536","Curated_Disease_Description__c":"Acute myelomonocytic leukemia (AMML) is a cancer that develops in the bone marrow and blood. AMML is one type of acute myeloid leukemia, a group of blood cancers that occur when the amount of white blood cells increases rapidly. Symptoms of AMML often include fatigue (due to anemia) or easy bruising or bleeding (due to thrombocytopenia). The cause of AMML is currently unknown.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"1,000","Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:98829","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0020316","ORPHANET_ID__c":"ORPHA:98829","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Leucemia mieloide aguda con eosinófilos anómalos en la médula ósea con inv(16)(p13q22) o t(16;16)(p13;q22)","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"leucemia mieloide aguda con eosinófilos anómalos en la médula ósea con inv(16)(p13q22) o t(16;16)(p13;q22)","Spanish_GARD_Synonym__c":"lma con eosinófilos anómalos de la médula ósea inv(16)(p13q22) o t(16;16)(p13;q22)","Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Acute myelomonocytic leukemia (AMML) is a cancer that develops in the bone marrow and blood. AMML is one type of acute myeloid leukemia, a group of blood cancers that occur when the amount of white blood cells increases rapidly. Symptoms of AMML often include fatigue (due to anemia) or easy bruising or bleeding (due to thrombocytopenia). The cause of AMML is currently unknown.","Curated_Disease_Description_Source__c":"GARD:0000536","GARD_Synonym__c":"acute myeloid leukemia with cbfb::myh11 fusion; acute myeloid leukemia with inv(16)(p13.1q22); acute myeloid leukemia with t(16;16)(p13.1;q22); acute myelomonocytic leukemia - eosinophilic variant; aml with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)","Name":"Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or","Curated_USA_Estimate__c":"1,000","estimateUsa":"1,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Leukaemia Foundation","Website__c":"https://www.leukaemia.org.au/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Hematology","Tag_Category__c":"Disease Category;Specialist","category_description":"Blood diseases affect the blood or blood-forming organs, including red blood cells, white blood cells, platelets, plasma, and bone marrow.","curated_tag_name":"Blood diseases"},{"Tag_Name__c":"Myeloid hemopathy","Tag_Category__c":"Account","curated_tag_name":"Blood or bone marrow disease"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:98829"}],"External_Identifier_Disease__c":[{"URL__c":"https://raresource.nih.gov/diseases/filter/0000536","Source__c":"RareSource"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C5395080","Source__c":"C5395080","Xref__c":"C5395080"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=1716406","Source__c":"C5395080","Xref__c":"MEDGEN:1716406"},{"URL__c":"https://www.orpha.net/en/disease/detail/98829","Source__c":"MONDO:0020316","Xref__c":"ORPHA:98829"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=838355002","Source__c":"C5395080","Xref__c":"838355002"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9287","Source__c":"C5395080; MONDO:0020316","Xref__c":"C9287"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0020316","Source__c":"GARD:0000536","Xref__c":"MONDO:0020316"}],"tags":{"Specialist":["Cancer - Oncologist","Hematology"],"Disease Category":["Cancer","Hematology"],"Account":["Myeloid hemopathy"]},"synonyms":["acute myeloid leukemia with cbfb::myh11 fusion"," acute myeloid leukemia with inv(16)(p13.1q22)"," acute myeloid leukemia with t(16","16)(p13.1","q22)"," acute myelomonocytic leukemia - eosinophilic variant"," aml with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16","16)(p13","q22)"]}