{"Name":"Uterine synechiae","DiseaseID__c":"GARD:0005853","id":5853,"encodedName":"uterine-synechiae","IsDeleted":false,"Disease_Name_Full__c":"Uterine synechiae","Xref_IDs__c":"48236007; C0156372; HP:0030712; MEDGEN:57629; MONDO:0015299; N85.6; ORPHA:137686","USA_Estimate__c":"200,000","No_of_Specialist_Tagsa__c":1,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"800,000 to 5,000,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"ORPHA:137686","Disease_Description__c":"A rare, acquired uterine disease characterized by intrauterine adhesions associated with a history of curettage or intrauterine surgery and gynecological symptoms (secondary amenorrhea, hypomenorrhea, pelvic pain, infertility or pregnancy loss).","GARD_Name__c":"Uterine synechiae","GARD_Synonym__c":"asherman syndrome; asherman's syndrome; intrauterine adhesions; intrauterine synechiae; traumatic intrauterine synechiae syndrome","Curated_Disease_Description_Source__c":"ORPHA:137686","Curated_Disease_Description__c":"A rare, acquired uterine disease characterized by intrauterine adhesions associated with a history of curettage or intrauterine surgery and gynecological symptoms (secondary amenorrhea, hypomenorrhea, pelvic pain, infertility or pregnancy loss).","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"200,000","Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:137686","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0015299","ORPHANET_ID__c":"ORPHA:137686","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Síndrome de asherman","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"síndrome de asherman","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:96344","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A rare, acquired uterine disease characterized by intrauterine adhesions associated with a history of curettage or intrauterine surgery and gynecological symptoms (secondary amenorrhea, hypomenorrhea, pelvic pain, infertility or pregnancy loss).","Curated_Disease_Description_Source__c":"ORPHA:137686","GARD_Synonym__c":"asherman syndrome; asherman's syndrome; intrauterine adhesions; intrauterine synechiae; traumatic intrauterine synechiae syndrome","Name":"Uterine synechiae","Curated_USA_Estimate__c":"200,000","estimateUsa":"200,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Resolve: The National Infertility Association","Website__c":"https://resolve.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Urogenital Disorders","Tag_Category__c":"Disease Category","category_description":"Urinary and reproductive diseases affect the kidneys, ureters, bladder, urethra, or the reproductive organs.","curated_tag_name":"Urinary and reproductive diseases"},{"Tag_Name__c":"Obstetrics / Gynecology","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:137686"}],"External_Identifier_Disease__c":[{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=48236007","Source__c":"C0156372; MONDO:0015299","Xref__c":"48236007"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=57629","Source__c":"C0156372","Xref__c":"MEDGEN:57629"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0156372","Source__c":"C0156372","Xref__c":"C0156372"},{"URL__c":"https://www.orpha.net/en/disease/detail/137686","Source__c":"C0156372; MONDO:0015299; ORPHA:137686","Xref__c":"ORPHA:137686"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/N85.6","Source__c":"MONDO:0015299","Xref__c":"N85.6"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0030712","Source__c":"C0156372","Xref__c":"HP:0030712"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0015299","Source__c":"GARD:0005853","Xref__c":"MONDO:0015299"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:137686","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Pain during menstruation that interferes with daily activities.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100607","HPO_Synonym__c":"Painful menstruation","HPO_Name__c":"Dysmenorrhea","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:137686","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Infrequent menses (less than 6 per year or more than 35 days between cycles).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000876","HPO_Synonym__c":"Light or infrequent menstrual periods","HPO_Name__c":"Oligomenorrhea","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:137686","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"Presence of a protracted or persistent infection by a pathogen potentially related to an underlying abnormality of the immune system that is not able to clear the infection.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0031035","HPO_Name__c":"Chronic infection","Feature_System__c":"Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:137686","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000789","HPO_Synonym__c":"Infertility","HPO_Name__c":"Infertility","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:137686","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Bleeding at irregular intervals.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100608","HPO_Synonym__c":"Abnormal uterus bleeding; Intermenstrual bleeding; Menstrual spotting","HPO_Name__c":"Metrorrhagia","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:137686","HPO_Frequency__c":"Uncommon (<1-4%)","Feature__r":{"HPO_Description__c":"An abnormality of the placenta, the organ that connects the developing fetus to the uterine wall to enable nutrient uptake, waste elimination, and gas exchange.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100767","HPO_Synonym__c":"Abnormality of the placenta; Placental issue","HPO_Name__c":"Abnormal placenta morphology","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:137686","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000869","HPO_Synonym__c":"Previous menstrual periods stop","HPO_Name__c":"Secondary amenorrhea","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:137686","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000868","HPO_Synonym__c":"Decreased fertility in females; Reduced fertility in females","HPO_Name__c":"Decreased fertility in females","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:137686","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"An abnormality of the ovulation cycle.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000140","HPO_Synonym__c":"Abnormality of the menstrual cycle","HPO_Name__c":"Abnormality of the menstrual cycle","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:137686","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An intermittent form of abdominal pain.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002574","HPO_Name__c":"Episodic abdominal pain","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Disease Category":["Urogenital Disorders"],"Specialist":["Obstetrics / Gynecology"]},"synonyms":["asherman syndrome"," asherman's syndrome"," intrauterine adhesions"," intrauterine synechiae"," traumatic intrauterine synechiae syndrome"]}