{"Name":"Astrocytoma, anaplastic","DiseaseID__c":"GARD:0005860","id":5860,"encodedName":"astrocytoma-anaplastic","IsDeleted":false,"Disease_Name_Full__c":"Astrocytoma, anaplastic","Xref_IDs__c":"55353007; C0334579; C9477; DOID:3078; MEDGEN:137784; MONDO:0016684; ORPHA:251589","USA_Estimate__c":"5,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"8,000 to 80,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0016684","Disease_Description__c":"A rare, high-grade, malignant glial tumor, histologically characterized by abundance of pleomorphic astrocytes and multiple mitotic figures, often associated with diffuse infiltration of the surrounding tissue, considerable edema and mass effect and involvement of the contralateral brain. Depending on the primary localization of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), seizures, progressive neurological deficits, and/or behavioral changes. The tumor is most commonly localized in the frontal and temporal lobes, brain stem and spinal cord.","GARD_Name__c":"Astrocytoma, anaplastic","GARD_Synonym__c":"anaplastic astrocytoma; astrocytoma, anaplastic, malignant; grade iii astrocytic neoplasm; grade iii astrocytic tumor; grade iii astrocytic tumour; grade iii astrocytoma; malignant astrocytoma","Curated_Disease_Description_Source__c":"GARD:0005860","Curated_Disease_Description__c":"Anaplastic astrocytoma is a rare, cancerous (malignant) type of brain tumor that arises from star-shaped brain cells called astrocytes. These cells surround and protect nerve cells in the brain and spinal cord. Signs and symptoms vary depending on the location and size of the tumor and may include headaches, drowsiness, vomiting, and changes in personality or mental status. Some affected people have seizures, vision problems, weakness of the limbs, and/or coordination problems. Anaplastic astroctyomas usually occur sporadically but can be associated with a few rare, genetic disorders.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"5,000","Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:251589","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0016684","ORPHANET_ID__c":"ORPHA:251589","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Astrocitoma anaplásico","Spanish_Description_Source__c":"ORPHA:251589","Spanish_Description__c":"Es un tumor glial maligno de alto grado y poco frecuente caracterizado histológicamente por la abundancia de astrocitos pleomórficos y múltiples figuras mitóticas y, a menudo, asociado con infiltración difusa del tejido circundante, edema y efecto masa considerables con afectación del cerebro contralateral. Dependiendo de la localización primaria del tumor, los afectados pueden presentar signos de aumento de la presión intracraneal (cefalea, vómitos, papiledema), convulsiones, deficiencia neurológica progresiva, y/o cambios de la conducta. Por lo general, el tumor se localiza en los lóbulos frontales y temporales, tronco cerebral y médula espinal.","Spanish_Disease_Name__c":"astrocitoma anaplásico","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Anaplastic astrocytoma is a rare, cancerous (malignant) type of brain tumor that arises from star-shaped brain cells called astrocytes. These cells surround and protect nerve cells in the brain and spinal cord. Signs and symptoms vary depending on the location and size of the tumor and may include headaches, drowsiness, vomiting, and changes in personality or mental status. Some affected people have seizures, vision problems, weakness of the limbs, and/or coordination problems. Anaplastic astroctyomas usually occur sporadically but can be associated with a few rare, genetic disorders.","Curated_Disease_Description_Source__c":"GARD:0005860","GARD_Synonym__c":"anaplastic astrocytoma; astrocytoma, anaplastic, malignant; grade iii astrocytic neoplasm; grade iii astrocytic tumor; grade iii astrocytic tumour; grade iii astrocytoma; malignant astrocytoma","Name":"Astrocytoma, anaplastic","Curated_USA_Estimate__c":"5,000","estimateUsa":"5,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Pediatric Brain Tumor Foundation","Website__c":"https://www.curethekids.org/"},{"Account_Name__c":"Brain Foundation","Website__c":"http://www.brainfoundation.org.au/"},{"Account_Name__c":"American Brain Tumor Association","Website__c":"https://www.abta.org/"},{"Account_Name__c":"National Brain Tumor Society","Website__c":"https://braintumor.org/"},{"Account_Name__c":"International Brain Tumour Alliance","Website__c":"https://theibta.org/"},{"Account_Name__c":"Neuro-Oncology Branch Brain Tumor Clinic","Website__c":"https://ccr.cancer.gov/Neuro-Oncology-Branch"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:251589"}],"External_Identifier_Disease__c":[{"URL__c":"https://raresource.nih.gov/diseases/filter/0005860","Source__c":"RareSource"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A3078","Source__c":"MONDO:0016684","Xref__c":"DOID:3078"},{"URL__c":"https://www.orpha.net/en/disease/detail/251589","Source__c":"C0334579; MONDO:0016684; ORPHA:251589","Xref__c":"ORPHA:251589"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0334579","Source__c":"C0334579","Xref__c":"C0334579"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=137784","Source__c":"C0334579","Xref__c":"MEDGEN:137784"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9477","Source__c":"C0334579; MONDO:0016684","Xref__c":"C9477"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0016684","Source__c":"GARD:0005860","Xref__c":"MONDO:0016684"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=55353007","Source__c":"C0334579","Xref__c":"55353007"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C129292","Source__c":"C0334579","Xref__c":"C129292"}],"tags":{"Specialist":["Cancer - Oncologist","Neurology"],"Disease Category":["Cancer","Neurology"]},"synonyms":["anaplastic astrocytoma"," astrocytoma, anaplastic, malignant"," grade iii astrocytic neoplasm"," grade iii astrocytic tumor"," grade iii astrocytic tumour"," grade iii astrocytoma"," malignant astrocytoma"]}