{"Name":"Diffuse astrocytoma","DiseaseID__c":"GARD:0005907","id":5907,"encodedName":"diffuse-astrocytoma","IsDeleted":false,"Disease_Name_Full__c":"Diffuse astrocytoma","Xref_IDs__c":"397381007; C0280785; C7173; DOID:4857; MEDGEN:83708; MONDO:0016686; ORPHA:251595","USA_Estimate__c":"5,000","No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"8,000 to 80,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":3,"Description_Source__c":"MONDO:0016686","Disease_Description__c":"A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse infiltration of neighboring central nervous system structures. These lesions typically affect young adults and have a tendency for progression to anaplastic astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified.","GARD_Name__c":"Diffuse astrocytoma","GARD_Synonym__c":"astrocytoma, diffuse; astrocytoma, diffuse, malignant; fibrillary astrocytoma (histologic variant); gemistocytic astrocytoma (histologic variant); grade ii astrocytic neoplasm; grade ii astrocytic tumor; grade ii astrocytic tumour; grade ii astrocytoma; low-grade diffuse astrocytoma; protoplasmic astrocytoma (histologic variant); who grade ii astrocytoma","Curated_Disease_Description_Source__c":"MONDO:0016686","Curated_Disease_Description__c":"A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse infiltration of neighboring central nervous system structures. These lesions typically affect young adults and have a tendency for progression to anaplastic astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"5,000","Age_at_Onset_Snippet_Text__c":"from Childhood to Adulthood","SourceID__c":"ORPHA:251595","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0016686","ORPHANET_ID__c":"ORPHA:251595","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Astrocitoma difuso","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"astrocitoma difuso","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse infiltration of neighboring central nervous system structures. These lesions typically affect young adults and have a tendency for progression to anaplastic astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified.","Curated_Disease_Description_Source__c":"MONDO:0016686","GARD_Synonym__c":"astrocytoma, diffuse; astrocytoma, diffuse, malignant; fibrillary astrocytoma (histologic variant); gemistocytic astrocytoma (histologic variant); grade ii astrocytic neoplasm; grade ii astrocytic tumor; grade ii astrocytic tumour; grade ii astrocytoma; low-grade diffuse astrocytoma; protoplasmic astrocytoma (histologic variant); who grade ii astrocytoma","Name":"Diffuse astrocytoma","Curated_USA_Estimate__c":"5,000","estimateUsa":"5,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Pediatric Brain Tumor Foundation","Website__c":"https://www.curethekids.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adolescent","Provided_By__c":"ORPHA:251595"},{"Age_At_Onset__c":"Childhood","Provided_By__c":"ORPHA:251595"},{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:251595"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0280785","Source__c":"C0280785","Xref__c":"C0280785"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A4857","Source__c":"MONDO:0016686","Xref__c":"DOID:4857"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=83708","Source__c":"C0280785","Xref__c":"MEDGEN:83708"},{"URL__c":"https://www.orpha.net/en/disease/detail/251595","Source__c":"C0280785; MONDO:0016686; ORPHA:251595","Xref__c":"ORPHA:251595"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C7173","Source__c":"C0280785; MONDO:0016686","Xref__c":"C7173"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0016686","Source__c":"GARD:0005907","Xref__c":"MONDO:0016686"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=397381007","Source__c":"C0280785","Xref__c":"397381007"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C129277","Source__c":"C0280785","Xref__c":"C129277"}],"tags":{"Specialist":["Cancer - Oncologist","Neurology","Pediatrics"],"Disease Category":["Cancer","Neurology"]},"synonyms":["astrocytoma, diffuse"," astrocytoma, diffuse, malignant"," fibrillary astrocytoma (histologic variant)"," gemistocytic astrocytoma (histologic variant)"," grade ii astrocytic neoplasm"," grade ii astrocytic tumor"," grade ii astrocytic tumour"," grade ii astrocytoma"," low-grade diffuse astrocytoma"," protoplasmic astrocytoma (histologic variant)"," who grade ii astrocytoma"]}