{"Name":"Burning mouth syndrome","DiseaseID__c":"GARD:0005974","id":5974,"encodedName":"burning-mouth-syndrome","IsDeleted":false,"Disease_Name_Full__c":"Burning mouth syndrome","Xref_IDs__c":"399165002; C0006430; C62545; D002054; DOID:4331; MEDGEN:14254; MONDO:0006687; ORPHA:353253","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":1,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":1,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":1,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0006687","Disease_Description__c":"A condition characterized by a burning or tingling sensation on the lips, tongue, or entire mouth.","GARD_Name__c":"Burning mouth syndrome","GARD_Synonym__c":"bms; bms - burning mouth syndrome; oral dysesthesia; orodynia; stomatodynia; stomatopyrosis","Curated_Disease_Description_Source__c":"GARD:0005974","Curated_Disease_Description__c":"Burning mouth syndrome is characterized by long-lasting burning sensations of the mouth. The pain may affect the tongue, gums, lips, palate, throat, or the entire mouth. Burning mouth syndrome may be primary or secondary. Experts believe that the primary form may be caused by damage to the nerves that control pain and taste. The secondary form is caused by an underlying medical condition. In many cases, the underlying cause in unknown.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:353253","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0006687","ORPHANET_ID__c":"ORPHA:353253","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Síndrome de boca ardiente","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"síndrome de boca ardiente","Spanish_GARD_Synonym__c":"bms; disestesia oral; estomatodinia; estomatopirosis; orodinia","Category_Linearization__c":"ORPHA:98006","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Burning mouth syndrome is characterized by long-lasting burning sensations of the mouth. The pain may affect the tongue, gums, lips, palate, throat, or the entire mouth. Burning mouth syndrome may be primary or secondary. Experts believe that the primary form may be caused by damage to the nerves that control pain and taste. The secondary form is caused by an underlying medical condition. In many cases, the underlying cause in unknown.","Curated_Disease_Description_Source__c":"GARD:0005974","GARD_Synonym__c":"bms; bms - burning mouth syndrome; oral dysesthesia; orodynia; stomatodynia; stomatopyrosis","Name":"Burning mouth syndrome","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Facial Pain Association","Website__c":"https://www.facepain.org/"},{"Account_Name__c":"The Migraine Trust","Website__c":"https://www.migrainetrust.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:353253"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C002054","Source__c":"C0006430; MONDO:0006687","Xref__c":"D002054"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=399165002","Source__c":"C0006430; MONDO:0006687","Xref__c":"399165002"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A4331","Source__c":"MONDO:0006687","Xref__c":"DOID:4331"},{"URL__c":"https://www.orpha.net/en/disease/detail/353253","Source__c":"C0006430; MONDO:0006687; ORPHA:353253","Xref__c":"ORPHA:353253"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=14254","Source__c":"C0006430","Xref__c":"MEDGEN:14254"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C62545","Source__c":"C0006430; MONDO:0006687","Xref__c":"C62545"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0006430","Source__c":"C0006430","Xref__c":"C0006430"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0006687","Source__c":"GARD:0005974","Xref__c":"MONDO:0006687"},{"URL__c":"https://www.nidcr.nih.gov/health-info/burning-mouth"}],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:353253","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002315","HPO_Synonym__c":"Headache; Headaches","HPO_Name__c":"Headache","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:353253","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"A distortion of the sense of taste, often characterized by the sensation of a metallic taste.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0031249","HPO_Synonym__c":"Altered sense of taste; Dysgeusia; Metallic taste; Metallic taste in mouth","HPO_Name__c":"Parageusia","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:353253","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Unstable emotional experiences and frequent mood changes; emotions that are easily aroused, intense, and/or disproportionate to events and circumstances.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000712","HPO_Name__c":"Emotional lability","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:353253","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Any structural abnormality of the fifth cranial nerve.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0010824","HPO_Synonym__c":"Abnormal trigeminal nerve morphology; Abnormality of the fifth cranial nerve; Abnormality of the nervus trigeminus","HPO_Name__c":"Abnormal fifth cranial nerve morphology","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:353253","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An abnormal pattern in the quality, quantity, or characteristics of sleep.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002360","HPO_Synonym__c":"Difficulty sleeping; Sleep abnormality; Sleep disturbances; Sleep dysfunction; Sleep-wake disturbance; Trouble sleeping","HPO_Name__c":"Sleep disturbance","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:353253","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Any abnormality of the gingiva (also known as gums).","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000168","HPO_Synonym__c":"Abnormality of the gums; Gingival abnormality","HPO_Name__c":"Abnormality of the gingiva","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:353253","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Inflamed tongue with hyperplastic (enlarged) fungiform papillae that is said to resemble a strawberry or raspberry.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0031042","HPO_Synonym__c":"Raspberry tongue","HPO_Name__c":"Strawberry tongue","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:353253","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Painful sensations elicited by a nonpainful cutaneous stimulus such as a light touch or gentle stroking over affected areas of the body. Sometimes referred to as hyperpathia or hyperalgesia. Often perceived as an intense burning, dyesthesias may outlast the stimulus by several seconds.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012534","HPO_Synonym__c":"Dysaesthesia; Hyperalgesia; Hyperpathia","HPO_Name__c":"Dysesthesia","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:353253","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Glossy appearance of the entire tongue surface.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0010298","HPO_Synonym__c":"Smooth lingual surface; Smooth surface of tongue; Smooth tongue","HPO_Name__c":"Smooth tongue","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:353253","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"A reduced ability to discriminate between different temperatures.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0010829","HPO_Synonym__c":"Abnormality of temperature sensation; Impaired temperature sensation; Impaired thermal sensitivity; Loss of temperature sensation","HPO_Name__c":"Impaired temperature sensation","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:353253","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the tongue.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0030811","HPO_Synonym__c":"Painful tongue","HPO_Name__c":"Tongue pain","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:353253","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover from these moods; having a pessimistic outlook on the future; feeling a pervasive sense of shame; having a low self-worth; experiencing thoughts of suicide and engaging in suicidal behavior.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000716","HPO_Synonym__c":"Depression; Depressive episode; Depressivity","HPO_Name__c":"Depression","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:353253","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An abnormality of somatosensory evoked potentials (SSEP), i.e., of the electrical signals of sensation going from the body to the brain in response to a defined stimulus. Recording electrodes are placed over the scalp, spine, and peripheral nerves proximal to the stimulation site. Clinical studies generally use electrical stimulation of peripheral nerves to elicit potentials. SSEP testing determines whether peripheral sensory nerves are able to transmit sensory information like pain, temperature, and touch to the brain. Abnormal SSEPs can result from dysfunction at the level of the peripheral nerve, plexus, spinal root, spinal cord, brain stem, thalamocortical projections, or primary somatosensory cortex.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0007377","HPO_Synonym__c":"Abnormality of SSEPs","HPO_Name__c":"Abnormality of somatosensory evoked potentials","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:353253","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Intense feelings of nervousness, tension, or panic often arise in response to interpersonal stresses. There is worry about the negative effects of past unpleasant experiences and future negative possibilities. Individuals may feel fearful, apprehensive, or threatened by uncertainty, and they may also have fears of falling apart or losing control.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000739","HPO_Synonym__c":"Anxiety; Anxiousness; Excessive, persistent worry and fear","HPO_Name__c":"Anxiety","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:353253","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000223","HPO_Synonym__c":"Abnormality of taste sensation","HPO_Name__c":"Abnormality of taste sensation","Feature_System__c":"Nervous System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:353253","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Dryness of the mouth due to salivary gland dysfunction.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000217","HPO_Synonym__c":"Dry mouth; Dry mouth syndrome; Reduced salivation","HPO_Name__c":"Xerostomia","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:353253","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"An intense sensation of burning, scalding, or tingling feeling of the tongue or other regions of the oral mucosa.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0032143","HPO_Name__c":"Burning mouth","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Disease Category":["Neurology"],"Specialist":["Neurology"]},"synonyms":["bms"," bms - burning mouth syndrome"," oral dysesthesia"," orodynia"," stomatodynia"," stomatopyrosis"]}