{"Name":"Scleredema","DiseaseID__c":"GARD:0005975","id":5975,"encodedName":"scleredema","IsDeleted":false,"Disease_Name_Full__c":"Scleredema","Xref_IDs__c":"95323007; C0036413; C85057; D012592; DOID:3140; MEDGEN:11346; MONDO:0006606; ORPHA:352763","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":4,"Description_Source__c":"MONDO:0006606","Disease_Description__c":"A usually benign and self-limited skin disorder of unknown etiology, characterized by induration of the skin. It may be associated with infection, diabetes mellitus, and hematologic malignancies. Morphologically, there is deposition of mucin in the dermis.","GARD_Name__c":"Scleredema","GARD_Synonym__c":"buschke scleredema; buschke's scleredema; buschkes scleredema; diabeticorum, scleredema; diabeticorums, scleredema; scleredema adultorum; scleredema adultorum of buschke; scleredema diabeticorum; scleredema diabeticorum of buschke; scleredema diabeticorums; scleredema, buschke's; scleredemas","Curated_Disease_Description_Source__c":"GARD:0005975","Curated_Disease_Description__c":"Scleredema is a form of cutaneous mucinosis, a diverse group of rare skin conditions that are characterized by an accumulation of mucin (a jelly-like complex carbohydrate substance) in the skin. Signs and symptoms of this condition include hardening and thickening of the skin which may restrict movement. Skin in affected areas may be red or brown and often has an 'orange-skin' appearance. In some cases, Scleredema resolves spontaneously on its own, while in other affected people, the condition persists for long periods of time.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"at a variety of ages","SourceID__c":"ORPHA:352763","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0006606","ORPHANET_ID__c":"ORPHA:352763","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Escleredema","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"escleredema","Spanish_GARD_Synonym__c":"escleredema de buschke","Category_Linearization__c":"ORPHA:89826","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Scleredema is a form of cutaneous mucinosis, a diverse group of rare skin conditions that are characterized by an accumulation of mucin (a jelly-like complex carbohydrate substance) in the skin. Signs and symptoms of this condition include hardening and thickening of the skin which may restrict movement. Skin in affected areas may be red or brown and often has an 'orange-skin' appearance. In some cases, Scleredema resolves spontaneously on its own, while in other affected people, the condition persists for long periods of time.","Curated_Disease_Description_Source__c":"GARD:0005975","GARD_Synonym__c":"buschke scleredema; buschke's scleredema; buschkes scleredema; diabeticorum, scleredema; diabeticorums, scleredema; scleredema adultorum; scleredema adultorum of buschke; scleredema diabeticorum; scleredema diabeticorum of buschke; scleredema diabeticorums; scleredema, buschke's; scleredemas","Name":"Scleredema","estimateUsa":""}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Dermatology","Tag_Category__c":"Account;Disease Category;Specialist","category_description":"Skin diseases, or integumentary system diseases, affect the skin, hair, nails, sweat glands, or oil glands.","curated_tag_name":"Skin diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:352763"},{"Age_At_Onset__c":"Childhood","Provided_By__c":"ORPHA:352763"},{"Age_At_Onset__c":"Infancy","Provided_By__c":"ORPHA:352763"},{"Age_At_Onset__c":"Adolescent","Provided_By__c":"ORPHA:352763"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A3140","Source__c":"MONDO:0006606","Xref__c":"DOID:3140"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C012592","Source__c":"C0036413; MONDO:0006606","Xref__c":"D012592"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C85057","Source__c":"C0036413; MONDO:0006606","Xref__c":"C85057"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0036413","Source__c":"C0036413","Xref__c":"C0036413"},{"URL__c":"https://www.orpha.net/en/disease/detail/352763","Source__c":"C0036413; MONDO:0006606; ORPHA:352763","Xref__c":"ORPHA:352763"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=11346","Source__c":"C0036413","Xref__c":"MEDGEN:11346"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=95323007","Source__c":"C0036413; MONDO:0006606","Xref__c":"95323007"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0006606","Source__c":"GARD:0005975","Xref__c":"MONDO:0006606"}],"tags":{"Account":["Dermatology"],"Disease Category":["Dermatology"],"Specialist":["Dermatology","Pediatrics"]},"synonyms":["buschke scleredema"," buschke's scleredema"," buschkes scleredema"," diabeticorum, scleredema"," diabeticorums, scleredema"," scleredema adultorum"," scleredema adultorum of buschke"," scleredema diabeticorum"," scleredema diabeticorum of buschke"," scleredema diabeticorums"," scleredema, buschke's"," scleredemas"]}