{"Name":"Chandler syndrome","DiseaseID__c":"GARD:0006033","id":6033,"encodedName":"chandler-syndrome","IsDeleted":false,"Disease_Name_Full__c":"Chandler syndrome","Xref_IDs__c":"392481002; C0544008; DOID:11554; MEDGEN:107777; MONDO:0020369; ORPHA:98979","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":3,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":4,"Disease_Characteristics_Score__c":3,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0020369","Disease_Description__c":"A clinical variant of iridocorneal endothelial (ICE) syndrome, characterized by very few iris abnormalities but more severe corneal edema and less severe secondary glaucoma than seen in the other two ICE syndrome variants: Cogan-Reese syndrome and essential iris atrophy.","GARD_Name__c":"Chandler syndrome","GARD_Synonym__c":"chandler's syndrome; dystrophy of corneal endothelium; endothelial corneal dystrophy; posterior membrane corneal dystrophy","Curated_Disease_Description_Source__c":"GARD:0006033","Curated_Disease_Description__c":"Chandler's syndrome is an eye disorder in which the single layer of cells lining the interior of the cornea proliferates, causing changes within the iris, corneal swelling, and unusually high pressure in the eye (glaucoma). In most cases, only one eye is affected. Symptoms may include reduced vision and pain. Chandler's syndrome more often affects females and usually presents sometime during middle age. The cause of this disease is unknown.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":"ORPHA:98979","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0020369","ORPHANET_ID__c":"ORPHA:98979","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Síndrome de chandler","Spanish_Description_Source__c":"ORPHA:98979","Spanish_Description__c":"Es una variante clínica del síndrome endotelial iridocorneal (ICE), se caracteriza por presentar muy pocas anomalías en el iris pero sí edemas corneales más graves y un glaucoma secundario menos grave que los vistos en las otras dos variantes del síndrome ICE: el síndrome de Cogan-Reese y la atrofia esencial del iris.","Spanish_Disease_Name__c":"síndrome de chandler","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:97966","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Chandler's syndrome is an eye disorder in which the single layer of cells lining the interior of the cornea proliferates, causing changes within the iris, corneal swelling, and unusually high pressure in the eye (glaucoma). In most cases, only one eye is affected. Symptoms may include reduced vision and pain. Chandler's syndrome more often affects females and usually presents sometime during middle age. The cause of this disease is unknown.","Curated_Disease_Description_Source__c":"GARD:0006033","GARD_Synonym__c":"chandler's syndrome; dystrophy of corneal endothelium; endothelial corneal dystrophy; posterior membrane corneal dystrophy","Name":"Chandler syndrome","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Glaucoma Research Foundation","Website__c":"http://www.glaucoma.org"},{"Account_Name__c":"Cornea Research Foundation of America","Website__c":"http://www.cornea.org"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Genetics","Tag_Category__c":"Cause;Disease Category;Specialist","category_description":"Genetic diseases affect the DNA, or genetic instructions, which directs how tissues, organs, and body systems function.","curated_tag_name":"Genetic diseases"},{"Tag_Name__c":"Ophthalmology","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Congenital Abnormality","Tag_Category__c":"Disease Category","category_description":"Birth defects are structural changes present at birth that can affect almost any part of the body, including how the body looks, works, or both.","curated_tag_name":"Birth defects"},{"Tag_Name__c":"Anterior segment of Eye","Tag_Category__c":"Specialist","curated_tag_name":"Front part of eye disease"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=107777","Source__c":"C0544008","Xref__c":"MEDGEN:107777"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A11554","Source__c":"MONDO:0020369","Xref__c":"DOID:11554"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0544008","Source__c":"C0544008","Xref__c":"C0544008"},{"URL__c":"https://www.orpha.net/en/disease/detail/98979","Source__c":"C0544008; MONDO:0020369; ORPHA:98979","Xref__c":"ORPHA:98979"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0020369","Source__c":"GARD:0006033","Xref__c":"MONDO:0020369"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=392481002","Source__c":"C0544008","Xref__c":"392481002"}],"tags":{"Cause":["Genetics"],"Disease Category":["Genetics","Congenital Abnormality"],"Specialist":["Genetics","Ophthalmology","Anterior segment of Eye"]},"synonyms":["chandler's syndrome"," dystrophy of corneal endothelium"," endothelial corneal dystrophy"," posterior membrane corneal dystrophy"]}