{"Name":"Choriocarcinoma","DiseaseID__c":"GARD:0006059","id":6059,"encodedName":"choriocarcinoma","IsDeleted":false,"Disease_Name_Full__c":"Choriocarcinoma","Xref_IDs__c":"1156971005; 188188009; C0008497; C2948; D002822; DOID:3594; HP:0100768; MEDGEN:40278; MONDO:0005207","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":0,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":2,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0005207","Disease_Description__c":"An aggressive malignant tumor arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Approximately half of the cases develop from a complete hydatidiform mole. A minority of cases arise in the testis or the ovaries. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected.","GARD_Name__c":"Choriocarcinoma","GARD_Synonym__c":"chorioblastoma; choriocarcinoma (disease); choriocarcinoma, malignant; chorioepithelioma; chorion carcinoma; chorionepithelioma; chorionic carcinoma","Curated_Disease_Description_Source__c":"MEDGEN:C0008497","Curated_Disease_Description__c":"A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0005207","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).","Curated_Disease_Description_Source__c":"MEDGEN:C0008497","GARD_Synonym__c":"chorioblastoma; choriocarcinoma (disease); choriocarcinoma, malignant; chorioepithelioma; chorion carcinoma; chorionepithelioma; chorionic carcinoma","Name":"Choriocarcinoma","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Pediatric Brain Tumor Foundation","Website__c":"https://www.curethekids.org/"},{"Account_Name__c":"American Cancer Society","Website__c":"https://www.cancer.org"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"}],"External_Identifier_Disease__c":[{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=188188009","Source__c":"C0008497; MONDO:0005207","Xref__c":"188188009"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=40278","Source__c":"C0008497","Xref__c":"MEDGEN:40278"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A3594","Source__c":"MONDO:0005207","Xref__c":"DOID:3594"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2948","Source__c":"C0008497; MONDO:0005207","Xref__c":"C2948"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C002822","Source__c":"C0008497; MONDO:0005207","Xref__c":"D002822"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0008497","Source__c":"C0008497","Xref__c":"C0008497"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0100768","Source__c":"C0008497","Xref__c":"HP:0100768"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=1156971005","Source__c":"C0008497","Xref__c":"1156971005"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0005207","Source__c":"GARD:0006059","Xref__c":"MONDO:0005207"}],"tags":{"Disease Category":["Cancer"]},"synonyms":["chorioblastoma"," choriocarcinoma (disease)"," choriocarcinoma, malignant"," chorioepithelioma"," chorion carcinoma"," chorionepithelioma"," chorionic carcinoma"]}