{"Name":"Ligneous conjunctivitis","DiseaseID__c":"GARD:0006187","id":6187,"encodedName":"ligneous-conjunctivitis","IsDeleted":false,"Disease_Name_Full__c":"Ligneous conjunctivitis","Xref_IDs__c":"403435005; C1274789; H10.51; MEDGEN:226895; MONDO:0100560","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":1,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":2,"Disease_Characteristics_Score__c":3,"No_of_Age_at_Onset__c":0,"Description_Source__c":"MONDO:0100560","Disease_Description__c":"A rare form of chronic conjunctivitis characterized by the development of firm fibrin-rich, woody-like pseudomembraneous lesions mainly on the tarsal conjunctivae. Ligneous conjunctivitis is usually the initial and most common manifestation of type I congenital plasminogen deficiency.","GARD_Name__c":"Ligneous conjunctivitis","GARD_Synonym__c":null,"Curated_Disease_Description_Source__c":"GARD:0006187","Curated_Disease_Description__c":"Ligneous conjunctivitis is a rare disorder characterized by the buildup of a protein called fibrin which causes inflammation of the conjunctiva (conjunctivitis) and leads to thick, woody (ligneous), inflamed growths that are yellow, white, or red. Ligneous conjunctivitis most often occurs on the inside of the eyelids, but may also affect the sclera, cornea and pupil, leading to vision loss. A systemic form of the condition may occur, affecting the mucous membranes of the larynx, vocal chords, nose, trachea, bronchi, vagina, cervix, and gingiva. The cause of Ligneous conjunctivitis is unknown. Autosomal recessive inheritance has been suggested in some cases. Ligneous conjunctivitis is sometimes associated with a condition known as congenital plasminogen deficiency.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":null,"SourceID__c":null,"Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0100560","ORPHANET_ID__c":null,"Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":null,"Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":null,"Spanish_GARD_Synonym__c":null,"Category_Linearization__c":null,"icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Ligneous conjunctivitis is a rare disorder characterized by the buildup of a protein called fibrin which causes inflammation of the conjunctiva (conjunctivitis) and leads to thick, woody (ligneous), inflamed growths that are yellow, white, or red. Ligneous conjunctivitis most often occurs on the inside of the eyelids, but may also affect the sclera, cornea and pupil, leading to vision loss. A systemic form of the condition may occur, affecting the mucous membranes of the larynx, vocal chords, nose, trachea, bronchi, vagina, cervix, and gingiva. The cause of Ligneous conjunctivitis is unknown. Autosomal recessive inheritance has been suggested in some cases. Ligneous conjunctivitis is sometimes associated with a condition known as congenital plasminogen deficiency.","Curated_Disease_Description_Source__c":"GARD:0006187","Name":"Ligneous conjunctivitis","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Autoimmune Association","Website__c":"https://autoimmune.org/"},{"Account_Name__c":"Autoimmune Registry","Website__c":"https://www.autoimmuneregistry.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Anterior segment of Eye","Tag_Category__c":"Specialist","curated_tag_name":"Front part of eye disease"}],"Diagnosis__c":[{"Type__c":"GTR","Curie__c":"MEDGEN:C1274789"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C1274789","Source__c":"C1274789","Xref__c":"C1274789"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=226895","Source__c":"C1274789","Xref__c":"MEDGEN:226895"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/H10.51","Source__c":"MONDO:0100560","Xref__c":"H10.51"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0100560","Source__c":"GARD:0006187","Xref__c":"MONDO:0100560"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=403435005","Source__c":"C1274789","Xref__c":"403435005"}],"tags":{"Specialist":["Anterior segment of Eye"]},"synonyms":[""]}