{"Name":"Carcinoma of esophagus","DiseaseID__c":"GARD:0006383","id":6383,"encodedName":"carcinoma-of-esophagus","IsDeleted":false,"Disease_Name_Full__c":"Carcinoma of esophagus","Xref_IDs__c":"372138000; 423022155; C0152018; C3513; DOID:1107; MEDGEN:56256; MONDO:0019086; ORPHA:70482","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":4,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":4,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0019086","Disease_Description__c":"Esophageal carcinoma (EC) is a tumor arising in the epithelial cells lining the esophagus and can be divided into two subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC).","GARD_Name__c":"Carcinoma of esophagus","GARD_Synonym__c":"carcinoma of the esophagus; carcinoma of the oesophagus; esophageal carcinoma; esophagus carcinoma; oesophageal carcinoma; oesophagus carcinoma","Curated_Disease_Description_Source__c":"GARD:0006383","Curated_Disease_Description__c":"Esophageal cancer is a cancer of the esophagus, the hollow tube that carries foods and liquids from the throat to the stomach. Symptoms that may develop as the cancer grows include heartburn, pain when swallowing, difficulty swallowing, a hoarse voice, a cough that does not go away, weight loss, and coughing up blood. The exact cause of Esophageal cancer usually is not known, but both environmental and genetic factors are thought to play a role in its development. For example, variationss in any of several genes may cause susceptibility to Esophageal cancer. Environmental factors that may increase a person's chance to develop Esophageal cancer include tobacco use, heavy alcohol use, older age, obesity, and damage to the esophagus from acid reflux (Barrett esophagus). The diagnosis may be based on imaging studies and tests such as chest X-ray, upper endoscopy, and a biopsy of tissue from the esophagus.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:70482","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0019086","ORPHANET_ID__c":"ORPHA:70482","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Carcinoma de esófago","Spanish_Description_Source__c":"ORPHA:70482","Spanish_Description__c":"El carcinoma esofágico (CE) es un tumor que surge en las células epiteliales que recubren el esófago y puede dividirse en dos subtipos: carcinoma escamoso de esófago (CEE) y adenocarcinoma de esófago (ACE) (consulte estos términos).","Spanish_Disease_Name__c":"carcinoma de esófago","Spanish_GARD_Synonym__c":"carcinoma esofágico; cáncer esofágico","Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Esophageal cancer is a cancer of the esophagus, the hollow tube that carries foods and liquids from the throat to the stomach. Symptoms that may develop as the cancer grows include heartburn, pain when swallowing, difficulty swallowing, a hoarse voice, a cough that does not go away, weight loss, and coughing up blood. The exact cause of Esophageal cancer usually is not known, but both environmental and genetic factors are thought to play a role in its development. For example, variationss in any of several genes may cause susceptibility to Esophageal cancer. Environmental factors that may increase a person's chance to develop Esophageal cancer include tobacco use, heavy alcohol use, older age, obesity, and damage to the esophagus from acid reflux (Barrett esophagus). The diagnosis may be based on imaging studies and tests such as chest X-ray, upper endoscopy, and a biopsy of tissue from the esophagus.","Curated_Disease_Description_Source__c":"GARD:0006383","GARD_Synonym__c":"carcinoma of the esophagus; carcinoma of the oesophagus; esophageal carcinoma; esophagus carcinoma; oesophageal carcinoma; oesophagus carcinoma","Name":"Carcinoma of esophagus","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Esophageal Cancer Action Network","Website__c":"https://ecan.org/"},{"Account_Name__c":"American Cancer Society","Website__c":"https://www.cancer.org"},{"Account_Name__c":"Cancer Hope Network","Website__c":"https://www.cancerhopenetwork.org/"},{"Account_Name__c":"Esophageal Cancer Awareness Association Inc.","Website__c":"https://www.ecaware.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Gastroenterology","Tag_Category__c":"Disease Category;Specialist","category_description":"Gastrointestinal diseases, or digestive diseases, affect the esophagus, stomach, small intestine, large intestine, liver, gallbladder, or pancreas.","curated_tag_name":"Gastrointestinal diseases"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:70482"}],"Diagnosis__c":[{"Type__c":"GTR","Curie__c":"MEDGEN:C0152018"},{"Type__c":"GTR","Curie__c":"MEDGEN:C0546837"}],"External_Identifier_Disease__c":[{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0152018","Source__c":"C0152018","Xref__c":"C0152018"},{"URL__c":"https://www.orpha.net/en/disease/detail/70482","Source__c":"C0152018; MONDO:0019086; ORPHA:70482","Xref__c":"ORPHA:70482"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=56256","Source__c":"C0152018","Xref__c":"MEDGEN:56256"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=372138000","Source__c":"C0152018; MONDO:0019086","Xref__c":"372138000"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3513","Source__c":"C0152018; MONDO:0019086","Xref__c":"C3513"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A1107","Source__c":"MONDO:0019086","Xref__c":"DOID:1107"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0019086","Source__c":"GARD:0006383","Xref__c":"MONDO:0019086"},{"URL__c":"https://hpo.jax.org/browse/term/HP:0011459","Source__c":"C0152018","Xref__c":"HP:0011459"},{"URL__c":"https://secure.ssa.gov/apps10/poms.nsf/lnx/0423022155","Xref__c":"423022155"},{"URL__c":"https://www.cancer.gov/types/esophageal"},{"URL__c":"https://www.cancer.gov/types/esophageal/patient/esophageal-treatment-pdq"},{"URL__c":"https://medlineplus.gov/esophagealcancer.html"}],"tags":{"Specialist":["Cancer - Oncologist","Gastroenterology"],"Disease Category":["Cancer","Gastroenterology"]},"synonyms":["carcinoma of the esophagus"," carcinoma of the oesophagus"," esophageal carcinoma"," esophagus carcinoma"," oesophageal carcinoma"," oesophagus carcinoma"]}