{"Name":"Acquired factor VIII deficiency disease","DiseaseID__c":"GARD:0006405","id":6405,"encodedName":"acquired-factor-viii-deficiency-disease","IsDeleted":false,"Disease_Name_Full__c":"Acquired factor VIII deficiency disease","Xref_IDs__c":"14230004; C0272325; C35345; C536392; MEDGEN:124426; MONDO:0035735; ORPHA:599480","USA_Estimate__c":null,"No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":null,"No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":4,"Description_Source__c":"MONDO:0035735","Disease_Description__c":"An acquired form of hemophilia A, resulting in spontaneous bleeding in individuals with no history of bleeding disorders. It is believed to be caused by spontaneous inhibition of clotting factor VIII by autoantibodies, and is usually associated with other autoimmune conditions.","GARD_Name__c":"Acquired factor VIII deficiency disease","GARD_Synonym__c":"acquired f8 deficiency; acquired factor viii deficiency; acquired hemophilia a; aha","Curated_Disease_Description_Source__c":"PlainLanguagePilotV1-Sep23","Curated_Disease_Description__c":"Acquired hemophilia A is a bleeding disorder that interferes with the body's blood clotting process. Signs and symptoms include prolonged bleeding, frequent nosebleeds, bruising throughout the body, solid swellings of congealed blood (hematomas), hematuria, and gastrointestinal or urologic bleeding. Acquired hemophilia A occurs when the body's immune system attacks and disables a certain protein that helps the blood clot (called coagulation factor VIII). About half of the cases are associated with other conditions, such as pregnancy, autoimmune disease, cancer, skin diseases, or allergic reactions to medications.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":null,"Age_at_Onset_Snippet_Text__c":"at a variety of ages","SourceID__c":"ORPHA:599480","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0035735","ORPHANET_ID__c":"ORPHA:599480","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Hemofilia a adquirida","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"hemofilia a adquirida","Spanish_GARD_Synonym__c":"deficiencia adquirida de f8; deficiencia adquirida de factor viii; haa","Category_Linearization__c":"ORPHA:97992","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Acquired hemophilia A is a bleeding disorder that interferes with the body's blood clotting process. Signs and symptoms include prolonged bleeding, frequent nosebleeds, bruising throughout the body, solid swellings of congealed blood (hematomas), hematuria, and gastrointestinal or urologic bleeding. Acquired hemophilia A occurs when the body's immune system attacks and disables a certain protein that helps the blood clot (called coagulation factor VIII). About half of the cases are associated with other conditions, such as pregnancy, autoimmune disease, cancer, skin diseases, or allergic reactions to medications.","Curated_Disease_Description_Source__c":"PlainLanguagePilotV1-Sep23","GARD_Synonym__c":"acquired f8 deficiency; acquired factor viii deficiency; acquired hemophilia a; aha","Name":"Acquired factor VIII deficiency disease","estimateUsa":""}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Canadian Hemophilia Society","Website__c":"https://www.hemophilia.ca"},{"Account_Name__c":"National Bleeding Disorders Foundation","Website__c":"https://www.bleeding.org/"},{"Account_Name__c":"World Federation of Hemophilia","Website__c":"https://wfh.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Hematology","Tag_Category__c":"Disease Category;Specialist","category_description":"Blood diseases affect the blood or blood-forming organs, including red blood cells, white blood cells, platelets, plasma, and bone marrow.","curated_tag_name":"Blood diseases"},{"Tag_Name__c":"Pediatrics","Tag_Category__c":"Specialist"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Childhood","Provided_By__c":"ORPHA:599480"},{"Age_At_Onset__c":"Elderly","Provided_By__c":"ORPHA:599480"},{"Age_At_Onset__c":"Adolescent","Provided_By__c":"ORPHA:599480"},{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:599480"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.orpha.net/en/disease/detail/599480","Source__c":"C0272325; MONDO:0035735; ORPHA:599480","Xref__c":"ORPHA:599480"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=124426","Source__c":"C0272325","Xref__c":"MEDGEN:124426"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C35345","Source__c":"C0272325; MONDO:0035735","Xref__c":"C35345"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0272325","Source__c":"C0272325","Xref__c":"C0272325"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C536392","Source__c":"MONDO:0035735","Xref__c":"C536392"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=14230004","Source__c":"C0272325","Xref__c":"14230004"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0035735","Source__c":"GARD:0006405","Xref__c":"MONDO:0035735"}],"tags":{"Disease Category":["Hematology"],"Specialist":["Hematology","Pediatrics"]},"synonyms":["acquired f8 deficiency"," acquired factor viii deficiency"," acquired hemophilia a"," aha"]}