{"Name":"Mucosa-associated lymphoma","DiseaseID__c":"GARD:0006485","id":6485,"encodedName":"mucosa-associated-lymphoma","IsDeleted":false,"Disease_Name_Full__c":"Mucosa-associated lymphoma","Xref_IDs__c":"277622004; C0242647; C3898; C88.4; DOID:0050909; MEDGEN:66942; MONDO:0007650; OMIM:137245; ORPHA:52417","USA_Estimate__c":"50,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"80,000 to 800,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":5,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0007650","Disease_Description__c":"An indolent, extranodal type of non-Hodgkin lymphoma composed of small B-lymphocytes (centrocyte-like cells). The gastrointestinal tract is the most common site of involvement. Other common sites of involvement include lung, head and neck, ocular adnexae, skin, thyroid, and breast. Gastric involvement is associated with the presence of H. pylori infection. (WHO, 2001)","GARD_Name__c":"Mucosa-associated lymphoma","GARD_Synonym__c":"extranodal marginal zone b-cell lymphoma; extranodal marginal zone b-cell lymphoma of mucosa-associated lymphoid tissue; extranodal marginal zone b-cell lymphoma of mucosa-associated lymphoid tissue (malt-lymphoma); extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; immunocytoma; lymphoma of mucosa-associated lymphoid tissue; lymphoma, malt, somatic; malt lymphoma; malt lymphoma, somatic; malt-lymphoma; maltoma; mucosa-associated lymphatic tissue lymphoma; mucosa-associated lymphoid tissue lymphoma","Curated_Disease_Description_Source__c":"MONDO:0007650","Curated_Disease_Description__c":"An indolent, extranodal type of non-Hodgkin lymphoma composed of small B-lymphocytes (centrocyte-like cells). The gastrointestinal tract is the most common site of involvement. Other common sites of involvement include lung, head and neck, ocular adnexae, skin, thyroid, and breast. Gastric involvement is associated with the presence of H. pylori infection. (WHO, 2001)","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"50,000","Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:52417","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Grouping","MONDO_ID__c":"MONDO:0007650","ORPHANET_ID__c":"ORPHA:52417","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Linfoma malt","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"linfoma malt","Spanish_GARD_Synonym__c":"linfoma de tejido linfoide asociado a mucosa; linfoma de tejido linfático asociado a mucosa; linfoma extranodal de zona marginal; maltoma","Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"An indolent, extranodal type of non-Hodgkin lymphoma composed of small B-lymphocytes (centrocyte-like cells). The gastrointestinal tract is the most common site of involvement. Other common sites of involvement include lung, head and neck, ocular adnexae, skin, thyroid, and breast. Gastric involvement is associated with the presence of H. pylori infection. (WHO, 2001)","Curated_Disease_Description_Source__c":"MONDO:0007650","GARD_Synonym__c":"extranodal marginal zone b-cell lymphoma; extranodal marginal zone b-cell lymphoma of mucosa-associated lymphoid tissue; extranodal marginal zone b-cell lymphoma of mucosa-associated lymphoid tissue (malt-lymphoma); extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; immunocytoma; lymphoma of mucosa-associated lymphoid tissue; lymphoma, malt, somatic; malt lymphoma; malt lymphoma, somatic; malt-lymphoma; maltoma; mucosa-associated lymphatic tissue lymphoma; mucosa-associated lymphoid tissue lymphoma","Name":"Mucosa-associated lymphoma","Curated_USA_Estimate__c":"50,000","estimateUsa":"50,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"HealthTree Foundation","Website__c":"https://healthtree.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Hematology","Tag_Category__c":"Disease Category;Specialist","category_description":"Blood diseases affect the blood or blood-forming organs, including red blood cells, white blood cells, platelets, plasma, and bone marrow.","curated_tag_name":"Blood diseases"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:52417"}],"Diagnosis__c":[{"Type__c":"GTR","Curie__c":"MEDGEN:C0242647"},{"Type__c":"GTR","Curie__c":"MEDGEN:C1850900"}],"External_Identifier_Disease__c":[{"URL__c":"https://raresource.nih.gov/diseases/filter/0006485","Source__c":"RareSource"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0242647","Source__c":"C0242647","Xref__c":"C0242647"},{"URL__c":"https://www.orpha.net/en/disease/detail/52417","Source__c":"C0242647; MONDO:0007650","Xref__c":"ORPHA:52417"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C3898","Source__c":"C0242647; MONDO:0007650","Xref__c":"C3898"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=66942","Source__c":"C0242647","Xref__c":"MEDGEN:66942"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A0050909","Source__c":"MONDO:0007650","Xref__c":"DOID:0050909"},{"URL__c":"https://www.omim.org/entry/137245","Source__c":"MONDO:0007650; ORPHA:52417","Xref__c":"OMIM:137245"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=277622004","Source__c":"C0242647; MONDO:0007650","Xref__c":"277622004"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0007650","Source__c":"GARD:0006485","Xref__c":"MONDO:0007650"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=397350003","Source__c":"C0242647","Xref__c":"397350003"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=445269007","Source__c":"C0242647","Xref__c":"445269007"},{"URL__c":"http://purl.bioontology.org/ontology/ICD10CM/C88.4","Source__c":"MONDO:0007650","Xref__c":"C88.4"},{"URL__c":"https://www.ncbi.nlm.nih.gov/mesh/C018442","Source__c":"C0242647","Xref__c":"D018442"}],"GARD_Disease_Gene__c":[{"GeneSymbol__c":"BCL10","Gene_Type__c":"protein-coding gene","Causal_Gene__c":true}],"Inheritance__c":["Non-Mendelian inheritance"],"GARD_Disease_Feature__c":[{"Provided_By__c":"ORPHA:52417","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Abnormal excessive perspiration (sweating) despite the lack of appropriate stimuli like hot and humid weather.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000975","HPO_Synonym__c":"Diaphoresis; Excessive sweating; Increased sweating; Profuse sweating; Sweating; Sweating profusely; Sweating, increased","HPO_Name__c":"Hyperhidrosis","Feature_System__c":"Skin System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:52417","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002113","HPO_Synonym__c":"Lung infiltrates; Pulmonic infiltration","HPO_Name__c":"Pulmonary infiltrates","Feature_System__c":"Respiratory system","HPO_Feature_Type__c":"Imaging_CT"}},{"Provided_By__c":"ORPHA:52417","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Nausea is a commonly encountered symptom that has been defined as an unpleasant painless subjective feeling that one will imminently vomit. Vomiting has been defined as the forceful expulsion of the contents of the stomach, duodenum, or jejunum through the oral cavity. While nausea and vomiting are often thought to exist on a temporal continuum, this is not always the case. There are situations when severe nausea may be present without emesis and less frequently, when emesis may be present without preceding nausea.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002017","HPO_Synonym__c":"Nausea and vomiting","HPO_Name__c":"Nausea and vomiting","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:52417","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An increased susceptibility to respiratory infections as manifested by a history of recurrent respiratory infections.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002205","HPO_Synonym__c":"Frequent respiratory infections; Multiple respiratory infections; Recurrent respiratory infections; respiratory infections, recurrent; Susceptibility to respiratory infections","HPO_Name__c":"Recurrent respiratory infections","Feature_System__c":"Respiratory system; Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:52417","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"A subjective feeling of tiredness characterized by a lack of energy and motivation.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012378","HPO_Synonym__c":"Fatigue; Tired; Tiredness","HPO_Name__c":"Fatigue","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:52417","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Inflammation of the uveal tract in which the primary site of inflammation is the retina or choroid.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012123","HPO_Synonym__c":"Choroiditis","HPO_Name__c":"Posterior uveitis","Feature_System__c":"Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:52417","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Enlargement (swelling) of a lymph node.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002716","HPO_Synonym__c":"Lymph node hyperplasia; Swollen lymph nodes","HPO_Name__c":"Lymphadenopathy","Feature_System__c":"Cardiovascular System; Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:52417","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Visual impairment (or vision impairment) is vision loss (of a person) to such a degree as to qualify as an additional support need through a significant limitation of visual capability resulting from either disease, trauma, or congenital or degenerative conditions that cannot be corrected by conventional means, such as refractive correction, medication, or surgery.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000505","HPO_Synonym__c":"Impaired vision; Loss of eyesight; Poor vision; Visual impairment","HPO_Name__c":"Visual impairment","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:52417","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"Swelling of lymph nodes within the mediastinum, the central compartment of the thoracic cavities that contains the heart and the great vessels, the esophagus, and trachea and other structures including lymph nodes.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0100721","HPO_Synonym__c":"Swollen lymph nodes in center of chest","HPO_Name__c":"Mediastinal lymphadenopathy","Feature_System__c":"Cardiovascular System; Immune System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:52417","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"A reduction in erythrocytes volume or hemoglobin concentration.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001903","HPO_Synonym__c":"Anaemia; Low number of red blood cells or hemoglobin","HPO_Name__c":"Anemia","Feature_System__c":"Blood and Blood-Forming Tissue","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:52417","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Body temperature elevated above the normal range.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001945","HPO_Synonym__c":"Fever; Hyperthermia; Pyrexia","HPO_Name__c":"Fever","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:52417","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An abnormality of the thyroid gland.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000820","HPO_Synonym__c":"Abnormality of the thyroid gland; Thyroid abnormality","HPO_Name__c":"Abnormality of the thyroid gland","Feature_System__c":"Endocrine System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:52417","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"A type of lymphoma that originates in B-cells.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0012191","HPO_Synonym__c":"B cell lymphoma","HPO_Name__c":"B-cell lymphoma","Feature_System__c":"Blood and Blood-Forming Tissue","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:52417","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002027","HPO_Synonym__c":"Abdominal pain; Pain in stomach; Stomach pain","HPO_Name__c":"Abdominal pain","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:52417","HPO_Frequency__c":"Very frequent (80-99%)","Feature__r":{"HPO_Description__c":"Reduction of total body weight.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0001824","HPO_Synonym__c":"Loss of weight","HPO_Name__c":"Weight loss","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:52417","HPO_Frequency__c":"Occasional (5-29%)","Feature__r":{"HPO_Description__c":"An abnormality of the nasolacrimal drainage system, which serves as a conduit for tear flow from the external eye to the nasal cavity.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0000614","HPO_Synonym__c":"Abnormality of the nasolacrimal system","HPO_Name__c":"Abnormal nasolacrimal system morphology","HPO_Feature_Type__c":"Symptom"}},{"Provided_By__c":"ORPHA:52417","HPO_Frequency__c":"Frequent (30-79%)","Feature__r":{"HPO_Description__c":"Infrequent or difficult evacuation of feces.","HPO_Feature_URL__c":"https://hpo.jax.org/browse/term/HP:0002019","HPO_Synonym__c":"Constipation; Costiveness; Dyschezia","HPO_Name__c":"Constipation","Feature_System__c":"Digestive System","HPO_Feature_Type__c":"Symptom"}}],"tags":{"Specialist":["Cancer - Oncologist","Hematology"],"Disease Category":["Cancer","Hematology"]},"synonyms":["extranodal marginal zone b-cell lymphoma"," extranodal marginal zone b-cell lymphoma of mucosa-associated lymphoid tissue"," extranodal marginal zone b-cell lymphoma of mucosa-associated lymphoid tissue (malt-lymphoma)"," extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue"," immunocytoma"," lymphoma of mucosa-associated lymphoid tissue"," lymphoma, malt, somatic"," malt lymphoma"," malt lymphoma, somatic"," malt-lymphoma"," maltoma"," mucosa-associated lymphatic tissue lymphoma"," mucosa-associated lymphoid tissue lymphoma"]}