{"Name":"Gliomatosis cerebri","DiseaseID__c":"GARD:0006514","id":6514,"encodedName":"gliomatosis-cerebri","IsDeleted":false,"Disease_Name_Full__c":"Gliomatosis cerebri","Xref_IDs__c":"1156413005; 26138003; C0334576; C4318; DOID:6128; MEDGEN:87267; MONDO:0016683; ORPHA:251582","USA_Estimate__c":"1,000","No_of_Specialist_Tagsa__c":2,"No_of_ClinGen_records__c":0,"No_of_GeneReviews__c":0,"No_of_HHS_records__c":0,"World_Estimate__c":"1 to 8,000","No_of_HRSA_records__c":0,"Evidence_Based_Score__c":0,"No_of_Disease_Descriptions__c":3,"Disease_Characteristics_Score__c":4,"No_of_Age_at_Onset__c":1,"Description_Source__c":"MONDO:0016683","Disease_Description__c":"A diffuse glial tumor which infiltrates the brain extensively, involving more than two lobes. It is frequently bilateral and often extends to the infratentorial structures, even to the spinal cord. It is probably of astrocytic origin, although GFAP expression may be scant or absent. (Adapted from WHO.)","GARD_Name__c":"Gliomatosis cerebri","GARD_Synonym__c":"astrocytosis cerebri; gliomatosis; gliomatosis cerebri (morphologic abnormality)","Curated_Disease_Description_Source__c":"GARD:0006514","Curated_Disease_Description__c":"Gliomatosis cerebri is a type of malignant (cancerous) brain tumor called a glioblastoma that develops from a specific type of brain cell called an astrocyte. It involves at least three sections (lobes) within the main part of the brain (cerebrum). It may also affect both sides of the cerebrum as well as the nerve cells within the brain (grey matter). There are two types of Gliomatosis cerebri. Type 1 (classic form) is characterized by scattered and widespread tumor cells and no apparent mass or tumor, while type 2 has similar characteristics in addition to a detectable mass or tumor. Signs and symptoms of Gliomatosis cerebri may include personality changes, memory disturbance, headaches, and seizures.","Curated_USA_Estimate_Source__c":null,"Curated_USA_Estimate__c":"1,000","Age_at_Onset_Snippet_Text__c":"as an Adult","SourceID__c":"ORPHA:251582","Deprecated__c":"No","Disease_Concept_Type__c":"Rare Disease Entity","MONDO_ID__c":"MONDO:0016683","ORPHANET_ID__c":"ORPHA:251582","Replaced_By_ID__c":null,"Display_Spanish_Disease_Name__c":"Gliomatosis cerebri","Spanish_Description_Source__c":null,"Spanish_Description__c":null,"Spanish_Disease_Name__c":"gliomatosis cerebri","Spanish_GARD_Synonym__c":null,"Category_Linearization__c":"ORPHA:250908","icd10_id__c":null,"mesh_id__c":null,"omim_id__c":null,"snomed_id__c":null,"umls_id__c":null,"GARD_Disease__c":[{"Curated_Disease_Description__c":"Gliomatosis cerebri is a type of malignant (cancerous) brain tumor called a glioblastoma that develops from a specific type of brain cell called an astrocyte. It involves at least three sections (lobes) within the main part of the brain (cerebrum). It may also affect both sides of the cerebrum as well as the nerve cells within the brain (grey matter). There are two types of Gliomatosis cerebri. Type 1 (classic form) is characterized by scattered and widespread tumor cells and no apparent mass or tumor, while type 2 has similar characteristics in addition to a detectable mass or tumor. Signs and symptoms of Gliomatosis cerebri may include personality changes, memory disturbance, headaches, and seizures.","Curated_Disease_Description_Source__c":"GARD:0006514","GARD_Synonym__c":"astrocytosis cerebri; gliomatosis; gliomatosis cerebri (morphologic abnormality)","Name":"Gliomatosis cerebri","Curated_USA_Estimate__c":"1,000","estimateUsa":"1,000"}],"Organization_Supported_Diseases__c":[{"Account_Name__c":"Pediatric Brain Tumor Foundation","Website__c":"https://www.curethekids.org/"},{"Account_Name__c":"American Brain Tumor Association","Website__c":"https://www.abta.org/"},{"Account_Name__c":"National Brain Tumor Society","Website__c":"https://braintumor.org/"},{"Account_Name__c":"Children's Brain Tumor Foundation","Website__c":"https://cbtf.org/"},{"Account_Name__c":"International Brain Tumour Alliance","Website__c":"https://theibta.org/"}],"GARD_Disease_Tag__c":[{"Tag_Name__c":"Cancer - Oncologist","Tag_Category__c":"Specialist"},{"Tag_Name__c":"Cancer","Tag_Category__c":"Disease Category","category_description":"Cancer is a disease in which some of the body's cells grow uncontrollably and can spread to other parts of the body.","curated_tag_name":"Cancer"},{"Tag_Name__c":"Neurology","Tag_Category__c":"Disease Category;Specialist","category_description":"Neurological diseases affect the brain, spinal cord, cranial nerves, autonomic nerves, or other peripheral nerves.","curated_tag_name":"Neurological diseases"}],"Age_At_Onset__c":[{"Age_At_Onset__c":"Adult","Provided_By__c":"ORPHA:251582"}],"External_Identifier_Disease__c":[{"URL__c":"https://www.orpha.net/en/disease/detail/251582","Source__c":"C0334576; MONDO:0016683; ORPHA:251582","Xref__c":"ORPHA:251582"},{"URL__c":"https://www.ncbi.nlm.nih.gov/medgen/?term=87267","Source__c":"C0334576","Xref__c":"MEDGEN:87267"},{"URL__c":"https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C4318","Source__c":"C0334576; MONDO:0016683","Xref__c":"C4318"},{"URL__c":"https://uts.nlm.nih.gov/uts/umls/concept/C0334576","Source__c":"C0334576","Xref__c":"C0334576"},{"URL__c":"https://www.ebi.ac.uk/ols4/ontologies/doid/classes?obo_id=DOID%3A6128","Source__c":"MONDO:0016683","Xref__c":"DOID:6128"},{"URL__c":"http://purl.obolibrary.org/obo/MONDO_0016683","Source__c":"GARD:0006514","Xref__c":"MONDO:0016683"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=1156413005","Source__c":"C0334576","Xref__c":"1156413005"},{"URL__c":"https://browser.ihtsdotools.org/?perspective=full&conceptId1=26138003","Source__c":"C0334576","Xref__c":"26138003"}],"tags":{"Specialist":["Cancer - Oncologist","Neurology"],"Disease Category":["Cancer","Neurology"]},"synonyms":["astrocytosis cerebri"," gliomatosis"," gliomatosis cerebri (morphologic abnormality)"]}